A Study of KF-0210 in Advanced Solid Tumors Patients

PHASE1CompletedINTERVENTIONAL
Enrollment

14

Participants

Timeline

Start Date

March 9, 2021

Primary Completion Date

December 8, 2022

Study Completion Date

April 27, 2023

Conditions
Advanced Solid TumorColorectal CancerLung CancerSquamous Cell Carcinoma of the EsophagusGastric CancerBladder Cancer
Interventions
DRUG

KF-0210 tablets, 120 mg

KF-0210 tablet will be orally administered as a single agent at 120 mg once daily (QD) continuously, until the disease progression, intolerance, or informed consent withdrawal.

DRUG

KF-0210 tablets, 240 mg

KF-0210 tablet will be orally administered as a single agent at 240 mg once daily (QD) continuously, until the disease progression, intolerance, or informed consent withdrawal.

DRUG

KF-0210 tablets, 450 mg

KF-0210 tablet will be orally administered as a single agent at 450 mg once daily (QD) continuously, until the disease progression, intolerance, or informed consent withdrawal.

DRUG

KF-0210 tablets, 600 mg

KF-0210 tablet will be orally administered as a single agent at 600 mg once daily (QD) continuously, until the disease progression, intolerance, or informed consent withdrawal.

DRUG

KF-0210 (dosage RP2D-2) + Atezolizumab

KF-0210 tablet will be orally administered at dosage RP2D-2 once daily (QD) in combination with Atezolizumab that will be administered at 1200 mg every 3 weeks via intravenously infusion.

DRUG

KF-0210 (dosage RP2D-1) + Atezolizumab

KF-0210 tablet will be orally administered at dosage RP2D-1 once daily (QD) in combination with Atezolizumab that will be administered at 1200 mg every 3 weeks via intravenously infusion.

DRUG

KF-0210 (dosage RP2D) + Atezolizumab

KF-0210 tablet will be orally administered at dosage RP2D once daily (QD) in combination with Atezolizumab that will be administered at 1200 mg every 3 weeks via intravenously infusion.

Trial Locations (1)

2031

Scientia Clinical Research Limited, Randwick

All Listed Sponsors
lead

Keythera Pharmaceuticals (Australia) Pty Ltd

INDUSTRY

NCT04713891 - A Study of KF-0210 in Advanced Solid Tumors Patients | Biotech Hunter | Biotech Hunter