A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

241

Participants

Timeline

Start Date

March 4, 2021

Primary Completion Date

April 7, 2023

Study Completion Date

December 31, 2027

Conditions
Chronic Graft-versus-host-disease
Interventions
DRUG

Axatilimab

Axatilimab is a high-affinity antibody targeting the colony stimulating factor 1 receptor (CSF-1R). CSF-1R signaling has been demonstrated in nonclinical studies to be the key regulatory pathway involved in the expansion and infiltration of donor-derived macrophages that mediate the disease processes involved in cGVHD.

Trial Locations (121)

100

National Taiwan University Hospital, Taipei

168

Fondazione Policlinica Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore, Roma

3052

The Royal Children's Hospital, Parkville

8032

Hospital Clinic Barcelona, Barcelona

10022

Weill Medical College of Cornell University, New York

11794

Stony Brook University Medical Center, Stony Brook

15232

University of Pittsburgh Medical Center - Hillman Cancer Center, Pittsburgh

18014

Complejo Hospitalario Universitario de Granada - Hospital Universitario Virgen de las Nieves, Granada

20010

Children's National Medical Center, Washington D.C.

20122

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano, Milan

20132

IRCCS Ospedale San Raffaele, Milan

22908

University of Virginia Medical Center, Charlottesville

26500

University General Hospital of Patras, Pátrai

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

27157

Wake Forest, Winston-Salem

28007

Hospital General Universitario Gregorio Maranon, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28046

Hospital Universitario La Paz, Madrid

30322

Emory University, Atlanta

30342

Northside Hospital, Atlanta

31100

IUCT-Oncopole, Toulouse

32224

Mayo Clinic - Jacksonville, Jacksonville

32610

University of Florida (UF), Gainesville

32806

AdventHealth Orlando, Orlando

33136

University of Miami, Miami

33612

Moffitt, Tampa

35233

University of Alabama at Birmingham - Children's of Alabama, Birmingham

35294

University of Alabama at Birmingham, Birmingham

37007

Hospital Clinico Universitario de Salamanca, Salamanca

37232

Vanderbilt University Medical Center, Nashville

38700

CHU de Grenoble, La Tronche

40447

China Medical University Hospital, Taichung

41013

Hospital Universitario Virgen del Rocio, Seville

43210

The Ohio State University Comprehensive Cancer Center, Columbus

44106

University Hospitals Cleveland Medical Center, Cleveland

44195

The Cleveland Clinic Foundation, Lyndhurst

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

46010

Hospital Clinico Universitario de Valencia, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

46202

Indiana University Health Melvin and Bren Simon Cancer Center, Indianapolis

46237

Franciscan Health Indianapolis, Indianapolis

48084

University of Michigan, Ann Arbor

48149

Universitaetsklinikum Muenster, Münster

48201

Barbara Ann Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

53226

Froedtert Hospital and the Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin - Carbone Cancer Center, Madison

55131

Universitaetsmedizin der Johannes Gutenberg - Universitaet Mainz, Mainz

55455

University of Minnesota, Minneapolis

55905

Mayo Clinic - Rochester, Rochester

57010

General Hospital of Thessaloniki G. Papanikolaou - Hematology Department, BMT Unit, Eksochi

59037

CHRU de Lille - Hopital Claude Huriez, Lille

60637

The University of Chicago Medical Center (UCMC), Chicago

63110

Washington University School of Medicine, St Louis

67200

Institut de cancérologie Strasbourg Europe (ICANS), Strasbourg

70112

Tulane University Medical Center, New Orleans

73104

University of Oklahoma - Health Sciences Center, Oklahoma City

75010

Hopital Saint Louis, Paris

75013

Hopital Pitie Salpetriere, Paris

77030

MD Anderson Cancer Center, Houston

80054

CHU Amiens Picardie - Hopital Sud, Amiens

80756

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

84111

Intermountain Healthcare, Salt Lake City

84112

University of Utah, Salt Lake City

90033

University of Southern California Norris Comprehensive Cancer Center, Los Angeles

90059

University of California, Los Angeles (UCLA) - Medical Center, Los Angeles

91010

City of Hope, Duarte

93053

Universitatsklinikum Regensburg, Regensburg

94305

Stanford Cancer Center, Stanford

97239

Oregon Health & Science University, Portland

98109

Fred Hutchinson Cancer Research Center, Seattle

119074

National University Hospital, Singapore

229899

KK Women's and Children hospital, Singapore

3109601

Rambam Health Care Campus, Haifa

5262160

Chaim Sheba Medical Center, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center, Tel Aviv

9112001

Hadassah Medical Center Ein Karem, Jerusalem

21231-2410

Johns Hopkins Kimmel Cancer Center, Baltimore

02114

Massachusetts General Hospital, Boston

02215

Dana Farber Cancer Institute, Boston

01655

University of Massachusetts Memorial Medical Center, Worcester

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

Unknown

Westmead Hospital, Westmead

Universitaire Ziekenhuizen Leuven, Leuven

AZ Delta, Roeselare

Princess Margaret Hospital, Toronto

CHRU de Nancy - Hôpitaux de Brabois, Nancy

CHU de Nantes - Hôtel-Dieu, Nantes

CHU Bordeaux - Hopital Haut-Leveque - Centre François Magendie, Pessac

HCL Centre Hospitalier Lyon Sud, Pierre-Bénite

University Hospital of West Attica - Attikon - Hematology Division, Athens

ASST degli Spedali Civili di Brescia, Brescia

ASST di Monza-Ospedale San Gerardo, Monza

Fondazione Monza e Brianza per il Bambino e la sua Mamma, Monza

Fondazione IRCCS Policlinico San Matteo, Pavia

AOU Citta della Salute e della Scienza di Torino - Ospedale Regina Margherita, Torino

Citta della Salute e della Scienza di Torino - Ospedale le Molinette, Torino

Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE, Porto

Singapore General Hospital, Singapore

Pusan National University Hospital, Busan

Korea University Anam Hospital, Seoul

Seoul National University Hospital, Seoul

Severance Hospital, Seoul

Hospital Universitario Donostia, Donostia / San Sebastian

Hospital Universitario Puerta de Hierro, Majadahonda

Hospital Universitario Marquis de Valdecilla, Santander

University Hospital of Wales, Cardiff

Queen Elizabeth University Hospital, Glasgow

Hammersmith Hospital, London

King's College Hospital NHS Foundation Trust, London

Royal Marsden Foundation Trust, London

V5Z 1M9

Vancouver Coastal Health Authority, Vancouver

H3G 1A4

McGill University Health Center - Research Institute, Montreal

H3T 1C5

CHU Sainte-Justine, Montreal

01307

Universitaetsklinikum Carl Gustav Carus Dresden, Dresden

07740

Universitaetsklinikum Jena, Jena

04103

Universitaetsklinikum Leipzig, Leipzig

44-102

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Oddzial w Gliwicach - Klinika Transplantacji Szpiku i Onkohematologii, Gliwice

1099-023

Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E. (IPO-Lisboa), Lisbon

08035

Hospital Universitario Vall d'Hebron, Barcelona

BS2 8BJ

Bristol Royal Hospital for Children, Bristol

Sponsors
All Listed Sponsors
lead

Syndax Pharmaceuticals

INDUSTRY