University of Pittsburgh Brain Health Initiative

Comprehensive testing of cognitive function and brain health.

A series of tests and questionnaires that asses vestibular function, balance, ocular-motor coordination, and reflexes.

A full assessment of sleep health, including insomnia (duration, frequency, daytime consequences) and other sleep disorders such as obstructive sleep apnea. Overnight sleep study is included.

A high-resolution MRI to provide qualitative and quantitative assessments of brain structure.

Participants will undergo an executive history and physical exam of all body systems.

These assessments will involve a series of tests and questionnaires that focus on physical function.

"A blood draw will be performed to measure standard clinical labs as part of a full history and physical, as well as additional analysis of biomarkers indicative of brain health.~An optional lumbar puncture will be performed and CSF samples (20-30 mL) stored in the NCTC Biorepository until shipment to the CLIA-certified laboratory.~Both CSF and blood samples will be analyzed for t-tau, p-tau, and Aβ42 and stored for future testing,"

Hearth health is evaluated through testing of arterial stiffness and pulse wave reflections using a high fidelity applanation tonometer.

PET imaging of the brain using tau and amyloid ligands.

PET imaging of the brain using an amyloid ligand.

PET imaging of the brain using a tau ligand.