A Study Evaluating Whether Pembrolizumab Alone or in Combination With CMP-001 Improves Efficacy of Treatment in Patients With Operable Melanoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

October 15, 2021

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8Melanoma of Unknown PrimaryPathologic Stage IIIB Cutaneous Melanoma AJCC v8Pathologic Stage IIIC Cutaneous Melanoma AJCC v8Pathologic Stage IIID Cutaneous Melanoma AJCC v8Recurrent Cutaneous Melanoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Computed Tomography

Undergo CT or PET/CT

BIOLOGICAL

Pembrolizumab

Given IV

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

PROCEDURE

Surgical Procedure

Undergo surgery

DRUG

VLP-encapsulated TLR9 Agonist CMP-001

Given SC or intratumorally

Trial Locations (188)

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

18015

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

18045

Saint Luke's Hospital-Anderson Campus, Easton

18104

Saint Luke's Cancer Center - Allentown, Allentown

18840

Guthrie Medical Group PC-Robert Packer Hospital, Sayre

18951

Saint Luke's Hospital-Quakertown Campus, Quakertown

22908

University of Virginia Cancer Center, Charlottesville

23298

VCU Massey Comprehensive Cancer Center, Richmond

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

45005

Dayton Physicians LLC-Atrium, Franklin

45236

Oncology Hematology Care Inc-Kenwood, Cincinnati

45331

Dayton Physicians LLC-Wayne, Greenville

Wayne Hospital, Greenville

45373

Dayton Physicians LLC - Troy, Troy

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Greater Dayton Cancer Center, Kettering

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45431

Indu and Raj Soin Medical Center, Beavercreek

45459

Dayton Physicians LLC-Miami Valley South, Centerville

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

Springfield Regional Medical Center, Springfield

45840

Armes Family Cancer Center, Findlay

Blanchard Valley Hospital, Findlay

Orion Cancer Care, Findlay

47374

Reid Health, Richmond

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49009

Beacon Kalamazoo Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49048

Beacon Kalamazoo, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

Trinity Health Muskegon Hospital, Muskegon

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

53226

Medical College of Wisconsin, Milwaukee

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

57105

Avera Cancer Institute, Sioux Falls

57401

Avera Cancer Institute-Aberdeen, Aberdeen

59802

Saint Patrick Hospital - Community Hospital, Missoula

60612

University of Illinois, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

62864

SSM Health Good Samaritan, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

Saint Francis Medical Center, Cape Girardeau

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

65401

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

Phelps Health Delbert Day Cancer Institute, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

70360

Terrebonne General Medical Center, Houma

70809

Louisiana Hematology Oncology Associates LLC, Baton Rouge

Mary Bird Perkins Cancer Center, Baton Rouge

72903

Mercy Hospital Fort Smith, Fort Smith

73120

Mercy Hospital Oklahoma City, Oklahoma City

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

The Medical Center of Aurora, Aurora

80112

Rocky Mountain Cancer Centers - Centennial, Centennial

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Rocky Mountain Cancer Centers - Swedish, Englewood

Swedish Medical Center, Englewood

The Melanoma and Skin Cancer Institute, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

Sky Ridge Medical Center, Lone Tree

80218

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

80260

Rocky Mountain Cancer Centers-Thornton, Thornton

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80539

Banner McKee Medical Center, Loveland

80631

Banner North Colorado Medical Center, Greeley

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92868

Saint Joseph Hospital - Orange, Orange

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94568

Epic Care-Dublin, Dublin

94597

Epic Care Cyberknife Center, Walnut Creek

94608

Bay Area Breast Surgeons Inc, Emeryville

Epic Care Partners in Cancer Care, Emeryville

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

Bay Area Tumor Institute, Oakland

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98107

Swedish Medical Center-Ballard Campus, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98368

Jefferson Healthcare, Port Townsend

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

99701

Fairbanks Memorial Hospital, Fairbanks

94553-3156

Contra Costa Regional Medical Center, Martinez

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

05602

Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners

05401

University of Vermont Medical Center, Burlington

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH