Albumin To Enhance Recovery After Acute Kidney Injury

PHASE4RecruitingINTERVENTIONAL
Enrollment

856

Participants

Timeline

Start Date

November 2, 2023

Primary Completion Date

August 28, 2025

Study Completion Date

October 23, 2025

Conditions
Acute Kidney InjuryRenal Replacement TherapyHypotensionCritical Illness
Interventions
BIOLOGICAL

20-25% Albumin fluid (100 mL)

"Participants will be randomized to receive albumin (20-25%) during their RRT sessions (either CRRT, SLED or IHD) in ICU. Once randomized the same fluid will be given for all subsequent RRT sessions for up to 14 days in ICU.~RRT sessions will be determined as per the treating physician. Boluses will be given at the start of, and halfway through, RRT sessions (i.e. for SLED sessions, at 0 and 4 hours; for IHD sessions, at 0 and 2 hours)."

OTHER

0.9% Normal Saline (100 mL)

"Participants will be randomized to receive normal saline 100 mL boluses during their RRT sessions (either CRRT, SLED or IHD) in ICU. Once randomized the same fluid will be given for all subsequent RRT sessions for up to 14 days in ICU.~RRT sessions will be determined as per the treating physician. Boluses will be given at the start of, and halfway through, RRT sessions (e.g. for 8 hour SLED sessions, at 0 and 4 hours; for 4 hour IHD sessions, at 0 and 2 hours; for CRRT, after starting/randomization then every 12 hours while continuing on CRRT)."

Trial Locations (16)

Unknown

NOT_YET_RECRUITING

The Governors of the University of Calgary, Calgary

NOT_YET_RECRUITING

University of Manitoba - Health Sciences Centre, Winnipeg

NOT_YET_RECRUITING

Nova Scotia Health Authority, Halifax

RECRUITING

Hamilton Health Sciences Corporation, Hamilton

NOT_YET_RECRUITING

Scarborough Health Network, Scarborough Village

RECRUITING

Centre Integre Universitaire de Sante et de Services Sociaux de L'Estrie - Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke

NOT_YET_RECRUITING

University of Saskatchewan, Saskatoon

K7L 2V7

RECRUITING

Kingston General Hospital, Kingston

M4N 3M5

RECRUITING

Sunnybrook Health Sciences Centre, North York

K1H 8L6

RECRUITING

The Ottawa Hospital, Ottawa

K1Y 4W7

RECRUITING

University of Ottawa Heart Institute, Ottawa

L2S0A9

RECRUITING

Niagara Health System, St. Catharines

M5B 1W8

NOT_YET_RECRUITING

St. Michael's Hospital, Toronto

M5G1X5

RECRUITING

Sinai Health System, Toronto

L1N 6K9

NOT_YET_RECRUITING

Lakeridge Health, Whitby

H7M3L9

RECRUITING

Centre Integre de Sante et de Services Sociaux de Laval, Laval

All Listed Sponsors
collaborator

The Physicians' Services Incorporated Foundation

OTHER

collaborator

The Kidney Foundation of Canada

OTHER

collaborator

The Ottawa Hospital Academic Medical Organization (TOHAMO) Innovation Fund Grant.

UNKNOWN

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

Canadian Blood Services

OTHER

collaborator

Héma-Québec

OTHER

lead

Ottawa Hospital Research Institute

OTHER