GI Effects of Iron in Healthy Volunteers

NACompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

March 1, 2021

Primary Completion Date

June 30, 2022

Study Completion Date

June 30, 2022

Conditions
Iron Deficiency Anemia TreatmentMicrobial ColonizationIron-deficiencyIron Deficiency Anemia
Interventions
DIAGNOSTIC_TEST

Lactulose breath test

Participants will complete a 3 hour breath test pre and post iron supplementation. This will include taking 4 exploratory samples for volatile organic compound (VOC) analysis.

OTHER

Stool sample

Participants will provide a stool sample pre and post iron supplementation

OTHER

Daily Diary

Monitoring stool form, consistency and frequency on a daily basis

OTHER

Irritable Bowel syndrome severity scoring system (IBS-SSS) questionnaire

Participants will complete the questionnaire pre and post iron supplementation

DIETARY_SUPPLEMENT

Ferrous Sulphate

Participants will take Ferrous sulphate 200mg (65mg elemental iron) for 4 weeks (+/- 2 days). Participants will be required to take 2 tablets per day.

Trial Locations (2)

M2 4NG

The Functional Gut Clinic, Cambridge

M3 4BG

The Functional Gut Clinic, Manchester

All Listed Sponsors
collaborator

Anglia Ruskin University

OTHER

lead

Dr Anthony Hobson

OTHER

NCT04705662 - GI Effects of Iron in Healthy Volunteers | Biotech Hunter | Biotech Hunter