Pregabalin vs. Gabapentin on Reducing Opioid Usage

PHASE4RecruitingINTERVENTIONAL
Enrollment

210

Participants

Timeline

Start Date

April 12, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
AnalgesicsGabapentinInjuriesNarcoticsPainTrauma
Interventions
DRUG

Pregabalin 50mg

Patients will receive 50 mg every 8 hours without dose titration. Patients with CrCl \< 60mL/min will receive same dose given q12 hours. The q12 hour regimen may be increased to q8 hours if CrCl increases above 60mL/min during the 7 days study period or until discharge (if \< 7 days post-enrollment).

DRUG

Gabapentin 300mg

Patients will receive 300 mg PO every 8 hours without dose titration. Patients with CrCl \< 60mL/min will receive same dose given q12 hours. The q12 hour regimen may be increased to q8 hours if CrCl increases above 60mL/min during the 7 days study period or until discharge (if \< 7 days post-enrollment).

DRUG

Neither Pregabalin nor Gabapentin

Patients will receive neither Pregabalin nor Gabapentin.

Trial Locations (1)

25301

RECRUITING

"Charleston Area Medical Centers Level 1 Trauma Center", Charleston

All Listed Sponsors
lead

CAMC Health System

OTHER