Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

490

Participants

Timeline

Start Date

May 21, 2021

Primary Completion Date

October 1, 2025

Study Completion Date

February 1, 2026

Conditions
Gastric Cancer, AdenocarcinomaGastroesophageal Junction Adenocarcinoma
Interventions
DRUG

Trastuzumab deruxtecan

6.4 mg/kg IV infusion every 3 weeks on Day 1 of each 21-day cycle

DRUG

Ramucirumab

8 mg/kg IV infusion on Days 1 and 15 of a 28-day cycle

DRUG

Paclitaxel

80 mg/m\^2 IV infusion on Days 1, 8, and 15 of a 28-day cycle

Trial Locations (156)

1062

Magyar Honvedseg Egeszs. K, Budapest

1200

UCL St. Luc, Brussels

1307

Uniklinikum Carl-Gustav-Carus, Dresden Sachsen

1330

SBU Adana Sehir Hastanesi, Adana

2650

Antwerp University Hospital, Edegem

3000

UZ Leuven, Leuven

3022

National Cancer Institute, Kyiv

4000

Exelsus, San Miguel de Tucumán

4032

Debreceni Egyetem Klinikai, Debrecen

4103

Universitares Krebszentrum, Leipzig

5000

IONC Instituto Oncologico de Cordoba - Fundacion Richardet Longo, Nueva Cordoba

7100

Pôle Hospitalier Jolimont, Haine-Saint-Paul

Tolna M. Balassa Janos Korhaz, Szekszárd

8173

MedicalCenter ASKLEPION LLC, Kyiv

8759

Christie Hospital, Manchester

10048

National Taiwan University Hospital NTUH, Taipei

10060

IRCC-FPO Candiolo, Candiolo

10449

MacKay Memorial Hospital, Taipei

11217

Taipei Veterans General Hosp, Taipei

13005

Hopital de la Timone, Marseille

13353

Charité-Unimedizin Berlin, Berlin

13620

Seoul Nati Univ Bundang Hosp, Seongnam

15706

Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela

20132

San Raffaele Hospital, Milan

20133

Istituto Nazionale dei Tumori, Milan

20142

Istituto Europeo di Oncologia S.r.L Divisione di Oncologia Medica Gastrointestinale e Tumori Neuroendocrini, Milan

20162

Ospedale Niguarda, Milan

20249

Häm-Onk. Praxis Eppendorf, Hamburg

22030

Trakya Universitesi Balkan, Edirne

22328

Institutul Oncologic Prof. Dr. Alexandru Trestiorean Bucuresti IOB, Bucharest

22763

Asklepios Tumorzentrum Altona, Hamburg

25000

CHU Besançon, Besançon

28007

H. Gregorio Maranon, Madrid

28034

Hosp Univ Ramón y Cajal, Madrid

28046

Hospital Universitario La Paz, Madrid

29200

CHRU, Brest

31008

Hospital de Navarra, Pamplona

33305

CGMF-Linkou Branch, Taoyuan District

34298

Institut de Recherche en Cancerologie de Montpellier IRCM, Montpellier

34722

Suleyman Yalcin Seh. Hast., Istanbul

35128

Istituto Oncologico Veneto, Padua

40447

China Medical Univ Hosp, Taichung

41404

Kyungpook Nat Uni Chilgok Hos, Daegu

42270

Pharmacie ICLN, Saint-Priest-en-Jarez

44280

Inonu Uni. Turgut Ozal Tip, Malatya

45136

Evang. Klin. Essen-Mitte gGmbH, Essen

46010

H. Clinico U. de Valencia, Valencia

49100

Davidoff Center, Petah Tikva

50010

Hebei Medical Univ 4th Hosp, Shijiazhuang

54907

Chonbuk National University Hospital - Jeonbuk Regional Cancer Center, Seoul

56126

Azienda Ospedaliero-Universitaria Pisana, Pisa

56162

AOU Pisana, Barone

58128

Chonnam National University Hwasun Hospital, Hwasun

59020

Centre Oscar Lambret, Lille

60488

Ins. für klinische onk. Forschung, Frankfurt Am Main Hessen

69059

"LLC Oncolife", Zaporizhzhia

69373

Centre Leon Berard, Lyon

70457

National Cheng Kung Univ Hosp, Tainan City

75012

Hopital Saint Antoine, Paris

75014

L Institut Mutualiste Montsouris, Paris

75015

Hopital Europeen G. Pompidou, Paris

80131

Aou Vanvitelli, Napoli

80756

KMUH, Kaohsiung City

83301

CGMF-Kaohsiung Branch, Kaohsiung City

84101

Soroka Univ Medical CTR, Be'er-Sheva Southern

88100

AOU Mater Domini, Catanzaro

94800

Gustave Roussy, étage -1., Villejuif

100142

Beijing Cancer Hospital, Beijing

100191

Peking Univ 3rd Hosp, Beijing

110042

Liaoning Cancer Hospital, Shenyang

119228

National Univ Cancer Inst SGP, Singapore

130031

The 1st Hospital of Jilin Univ, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

169610

National Cancer Centre Singapore, Singapore

196604

"Private Medical Institution Euromedservice", Saint Petersburg

198255

City Clinical Oncology Dispensary, Saint Petersburg

200000

Zhongshan Hosp Fudan Univ, Shanghai

200080

Shanghai First People's Hosp, Shanghai

200542

Centrul de Oncologie Sf. Nectarie, Craiova

230001

Anhui Provincial Hospital, Heifi

250117

Shandong Cancer Hospital & Institute, Jinan

276000

Linyi Cancer Hospital, Linyi

310018

Sir Run Run Shaw Hospital, Hangzhou

310022

Zhejiang Medical University - Zhejiang Cancer Hospital, Hangzhou

330006

1 Affiliated H of Nanchang U, Nanchang

350014

Fujian Medical University - Fujian Provincial Cancer Hospital, Fuzhou

361003

Xiamen University - The First Affiliated Hospital, Xiamen

400641

S.C. Medisprof SRL, Cluj-Napoca

410008

Zhongnan univ Xiangya hosp, Changshan

430295

S.C. Oncopremium-Team SRL, Baia Mare

450018

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

450054

Republican Clinical Oncology Dispensary, Ufa

454087

SBIH Chelyabinsk Regional Clinical Centre of Oncology and Nuclear Medicine, Chelyabinsk

510655

The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou

830000

Xinjiang Medical University - Cancer Hospital, Ürümqi

4810469

SIM Centro de Investigacion Clinica, Temuco

5265601

The Chaim Sheba Medical Center, Ramat Gan

7500921

Fundacion Arturo Lopez Perez, Santiago

7550000

Clinica San Carlos de Apoquindo, Santiago

C1426

Instituto Medico Especializado Alexander Fleming, Colegiales

C1125 ABD

Fundacion Cenit, Buenos Aires

30130-090

PERSONAL - Oncologia de Precisao e Personalizada, Belo Horizonte

70200-730

Hospital Sirio Libanes, Brasília

98700-000

ONCOSITE - Centro de Pesquisa Clinica em Oncologia LTDA, Ijuí

90160-092

Hospital Ernesto Dornelles, Porto Alegre

Unknown

1Affiliated H of Sun Yat Sen U, Guangzhou

Jiangsu Province Hosp, Nanjing

1st Hosp of China Medical Univ, Shenyang

Fudan University - Shanghai Cancer Center, Shanghai

Pamela Youde Nethersole Eastern Hospital, Chai Wan

Princess Margaret Hospital, Hong Kong

Queen Mary Hospital, Hong Kong

The Chinese University of Hong Kong (CUHK) - Prince of Wales Hospital (PWH) - Vascular and Interventional Radiology Foundation (VIRF) Clinical Science Centre, Hong Kong

Cork University Hospital, Cork

Azienda Ospedaliero-Universitaria di Modena, Modena

D-50937

Uni zu Koln-Unikl. Koln, Kln Nordrhein-westfalen

4835-044

Tallaght University Hospital, Dublin

5000-508

Beaumont Hospital, Dublin

Dublin 8

St James's Hospital, Dublin

464-8681

Aichi Cancer Center Hospital, Nagoya

104-0045

National Cancer Center Hospital, Chūōku

541-8567

Osaka International Cancer Institute, Chūōku

501-1194

Gifu University Hospital, Gifu

277-8577

National Cancer Center Hospital East, Kashiwa

650-0047

Kobe City Medical Center General Hospital, Kobe

781-8555

Kochi Health Sciences Center, Kochi

135-8550

The Cancer Institute Hospital of JFCR, Kōtoku

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

951-8566

Niigata Cancer Center Hospital, Niigata

589-8511

Kindai University Hospital, Ōsaka-sayama

565-0871

Osaka University Hospital, Suita

02-781

Sklodowska-Curie Inst Oncology, Warsaw

50-556

Uniwersytecki Szpital Kliniczny im.Mikulicza-Radeckiego, Wroclaw

4200-072

Hospital Sra da Oliveira, Creixomil E Mariz

Instituto Portugues De Oncologia Do Porto Francisco Gentil, E.P.E., Porto

D24 NR0A

C Hosp Tras Montes Alto Douro, Vila Real

02841

Korea Univ Anam Hosp, Seoul

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

Seoul St. Marys Hospital, Seoul

08035

Hospital Vall d'Hebron, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

08916

Hospital Germans Trias i Pujol, Barcelona

B15 2TH

University Hospitals Birmingham UHB NHS Foundation Trust - Queen Elizabeth Hospital Birmingham QEHB, Birmingham

CB2 0QQ

Addenbrooke's Hospital, Cambridge

CF14 2TL

Velindre NHS Trust - Velindre Cancer Centre VCC, Cardiff

DD1 9SY

Ninewells Hospital, Dundee

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

L9 7BA

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

NW1 2PG

UCLH Trust, London

SW3 6JJ

Royal Marsden NHS, London

OX3 7DQ

University of Oxford, The Churchill Hospital, Oxford

SM2 5PT

Royal Marsden Sutton, Sutton

LS9 7TF

Leeds Teaching Hospitals NHS Trust, West Yorkshire

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Daiichi Sankyo

INDUSTRY