490
Participants
Start Date
May 21, 2021
Primary Completion Date
October 1, 2025
Study Completion Date
February 1, 2026
Trastuzumab deruxtecan
6.4 mg/kg IV infusion every 3 weeks on Day 1 of each 21-day cycle
Ramucirumab
8 mg/kg IV infusion on Days 1 and 15 of a 28-day cycle
Paclitaxel
80 mg/m\^2 IV infusion on Days 1, 8, and 15 of a 28-day cycle
Magyar Honvedseg Egeszs. K, Budapest
UCL St. Luc, Brussels
Uniklinikum Carl-Gustav-Carus, Dresden Sachsen
SBU Adana Sehir Hastanesi, Adana
Antwerp University Hospital, Edegem
UZ Leuven, Leuven
National Cancer Institute, Kyiv
Exelsus, San Miguel de Tucumán
Debreceni Egyetem Klinikai, Debrecen
Universitares Krebszentrum, Leipzig
IONC Instituto Oncologico de Cordoba - Fundacion Richardet Longo, Nueva Cordoba
Pôle Hospitalier Jolimont, Haine-Saint-Paul
Tolna M. Balassa Janos Korhaz, Szekszárd
MedicalCenter ASKLEPION LLC, Kyiv
Christie Hospital, Manchester
National Taiwan University Hospital NTUH, Taipei
IRCC-FPO Candiolo, Candiolo
MacKay Memorial Hospital, Taipei
Taipei Veterans General Hosp, Taipei
Hopital de la Timone, Marseille
Charité-Unimedizin Berlin, Berlin
Seoul Nati Univ Bundang Hosp, Seongnam
Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela
San Raffaele Hospital, Milan
Istituto Nazionale dei Tumori, Milan
Istituto Europeo di Oncologia S.r.L Divisione di Oncologia Medica Gastrointestinale e Tumori Neuroendocrini, Milan
Ospedale Niguarda, Milan
Häm-Onk. Praxis Eppendorf, Hamburg
Trakya Universitesi Balkan, Edirne
Institutul Oncologic Prof. Dr. Alexandru Trestiorean Bucuresti IOB, Bucharest
Asklepios Tumorzentrum Altona, Hamburg
CHU Besançon, Besançon
H. Gregorio Maranon, Madrid
Hosp Univ Ramón y Cajal, Madrid
Hospital Universitario La Paz, Madrid
CHRU, Brest
Hospital de Navarra, Pamplona
CGMF-Linkou Branch, Taoyuan District
Institut de Recherche en Cancerologie de Montpellier IRCM, Montpellier
Suleyman Yalcin Seh. Hast., Istanbul
Istituto Oncologico Veneto, Padua
China Medical Univ Hosp, Taichung
Kyungpook Nat Uni Chilgok Hos, Daegu
Pharmacie ICLN, Saint-Priest-en-Jarez
Inonu Uni. Turgut Ozal Tip, Malatya
Evang. Klin. Essen-Mitte gGmbH, Essen
H. Clinico U. de Valencia, Valencia
Davidoff Center, Petah Tikva
Hebei Medical Univ 4th Hosp, Shijiazhuang
Chonbuk National University Hospital - Jeonbuk Regional Cancer Center, Seoul
Azienda Ospedaliero-Universitaria Pisana, Pisa
AOU Pisana, Barone
Chonnam National University Hwasun Hospital, Hwasun
Centre Oscar Lambret, Lille
Ins. für klinische onk. Forschung, Frankfurt Am Main Hessen
"LLC Oncolife", Zaporizhzhia
Centre Leon Berard, Lyon
National Cheng Kung Univ Hosp, Tainan City
Hopital Saint Antoine, Paris
L Institut Mutualiste Montsouris, Paris
Hopital Europeen G. Pompidou, Paris
Aou Vanvitelli, Napoli
KMUH, Kaohsiung City
CGMF-Kaohsiung Branch, Kaohsiung City
Soroka Univ Medical CTR, Be'er-Sheva Southern
AOU Mater Domini, Catanzaro
Gustave Roussy, étage -1., Villejuif
Beijing Cancer Hospital, Beijing
Peking Univ 3rd Hosp, Beijing
Liaoning Cancer Hospital, Shenyang
National Univ Cancer Inst SGP, Singapore
The 1st Hospital of Jilin Univ, Changchun
Harbin Medical University Cancer Hospital, Harbin
National Cancer Centre Singapore, Singapore
"Private Medical Institution Euromedservice", Saint Petersburg
City Clinical Oncology Dispensary, Saint Petersburg
Zhongshan Hosp Fudan Univ, Shanghai
Shanghai First People's Hosp, Shanghai
Centrul de Oncologie Sf. Nectarie, Craiova
Anhui Provincial Hospital, Heifi
Shandong Cancer Hospital & Institute, Jinan
Linyi Cancer Hospital, Linyi
Sir Run Run Shaw Hospital, Hangzhou
Zhejiang Medical University - Zhejiang Cancer Hospital, Hangzhou
1 Affiliated H of Nanchang U, Nanchang
Fujian Medical University - Fujian Provincial Cancer Hospital, Fuzhou
Xiamen University - The First Affiliated Hospital, Xiamen
S.C. Medisprof SRL, Cluj-Napoca
Zhongnan univ Xiangya hosp, Changshan
S.C. Oncopremium-Team SRL, Baia Mare
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
Republican Clinical Oncology Dispensary, Ufa
SBIH Chelyabinsk Regional Clinical Centre of Oncology and Nuclear Medicine, Chelyabinsk
The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou
Xinjiang Medical University - Cancer Hospital, Ürümqi
SIM Centro de Investigacion Clinica, Temuco
The Chaim Sheba Medical Center, Ramat Gan
Fundacion Arturo Lopez Perez, Santiago
Clinica San Carlos de Apoquindo, Santiago
Instituto Medico Especializado Alexander Fleming, Colegiales
Fundacion Cenit, Buenos Aires
PERSONAL - Oncologia de Precisao e Personalizada, Belo Horizonte
Hospital Sirio Libanes, Brasília
ONCOSITE - Centro de Pesquisa Clinica em Oncologia LTDA, Ijuí
Hospital Ernesto Dornelles, Porto Alegre
1Affiliated H of Sun Yat Sen U, Guangzhou
Jiangsu Province Hosp, Nanjing
1st Hosp of China Medical Univ, Shenyang
Fudan University - Shanghai Cancer Center, Shanghai
Pamela Youde Nethersole Eastern Hospital, Chai Wan
Princess Margaret Hospital, Hong Kong
Queen Mary Hospital, Hong Kong
The Chinese University of Hong Kong (CUHK) - Prince of Wales Hospital (PWH) - Vascular and Interventional Radiology Foundation (VIRF) Clinical Science Centre, Hong Kong
Cork University Hospital, Cork
Azienda Ospedaliero-Universitaria di Modena, Modena
Uni zu Koln-Unikl. Koln, Kln Nordrhein-westfalen
Tallaght University Hospital, Dublin
Beaumont Hospital, Dublin
St James's Hospital, Dublin
Aichi Cancer Center Hospital, Nagoya
National Cancer Center Hospital, Chūōku
Osaka International Cancer Institute, Chūōku
Gifu University Hospital, Gifu
National Cancer Center Hospital East, Kashiwa
Kobe City Medical Center General Hospital, Kobe
Kochi Health Sciences Center, Kochi
The Cancer Institute Hospital of JFCR, Kōtoku
National Hospital Organization Shikoku Cancer Center, Matsuyama
Niigata Cancer Center Hospital, Niigata
Kindai University Hospital, Ōsaka-sayama
Osaka University Hospital, Suita
Sklodowska-Curie Inst Oncology, Warsaw
Uniwersytecki Szpital Kliniczny im.Mikulicza-Radeckiego, Wroclaw
Hospital Sra da Oliveira, Creixomil E Mariz
Instituto Portugues De Oncologia Do Porto Francisco Gentil, E.P.E., Porto
C Hosp Tras Montes Alto Douro, Vila Real
Korea Univ Anam Hosp, Seoul
Seoul National University Hospital, Seoul
Severance Hospital, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Seoul St. Marys Hospital, Seoul
Hospital Vall d'Hebron, Barcelona
Hospital Clinic de Barcelona, Barcelona
Hospital Germans Trias i Pujol, Barcelona
University Hospitals Birmingham UHB NHS Foundation Trust - Queen Elizabeth Hospital Birmingham QEHB, Birmingham
Addenbrooke's Hospital, Cambridge
Velindre NHS Trust - Velindre Cancer Centre VCC, Cardiff
Ninewells Hospital, Dundee
Beatson West of Scotland Cancer Centre, Glasgow
The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool
UCLH Trust, London
Royal Marsden NHS, London
University of Oxford, The Churchill Hospital, Oxford
Royal Marsden Sutton, Sutton
Leeds Teaching Hospitals NHS Trust, West Yorkshire
Lead Sponsor
Collaborators (1)
AstraZeneca
INDUSTRY
Daiichi Sankyo
INDUSTRY