A Randomized Trial of Delayed Radiotherapy in Patients Low-grade Oligodendrogliomas Requiring a Treatment Other Than Surgery

PHASE3RecruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

December 7, 2021

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2030

Conditions
OligodendrogliomaLow-grade Oligodendroglioma1p19q Codeletion
Interventions
DRUG

PCV chemotherapy

"1. cycle of PCV chemotherapy is given as:~ * Day 1: CCNU 110 mg/m2 orally;~ * Days 8 and 29: Vincristine 1.4 mg/m2 IV;~ * Days 8 to 21: Procarbazine 60 mg/m2 orally~6 cycles are given."

DRUG

Radiotherapy and PCV chemotherapy

"Radiotherapy will deliver 50.4 Gy in 28 fractions of 1.8 Gy using IMRT technique.~Followed by 6 cycles of PCV chemotherapy~1 cycle of PCV is given as:~* Day 1: CCNU 110 mg/m2 orally;~* Days 8 and 29: Vincristine 1.4 mg/m2 IV;~* Days 8 to 21: Procarbazine 60 mg/m2 orally"

Trial Locations (26)

13005

RECRUITING

Hôpital Timone, Marseille

14033

NOT_YET_RECRUITING

CHU de Caen, Caen

21000

NOT_YET_RECRUITING

Centre Georges Francois Leclerc, Dijon

29200

RECRUITING

Institut de Cancérologie et Hematologie (ICH) - CHRU Brest, Hopital Morvan, Brest

31059

NOT_YET_RECRUITING

Institut Universitaire du Cancer Toulouse Oncopole, Toulouse

33075

RECRUITING

CHU de Bordeaux Hôpital Saint André, Bordeaux

35042

RECRUITING

Centre Eugène Marquis, Rennes

37044

NOT_YET_RECRUITING

CHRU de Tours, Tours

42055

NOT_YET_RECRUITING

CHU Saint-Etienne, Saint-Etienne

44805

RECRUITING

Institut de Cancerologie de l'Ouest, Saint-Herblain

49055

RECRUITING

Institut de Cancerologie de l'Ouest, Angers

59037

RECRUITING

Hôpital Roger Salengro CHU de Lille, Lille

67200

RECRUITING

Institut de Cancérologie Strasbourg Europe, Strasbourg

68024

NOT_YET_RECRUITING

Hôpital Pasteur - Hôpitaux civils de Colmar, Colmar

69008

NOT_YET_RECRUITING

Centre Léon Bérard, Lyon

69500

RECRUITING

Hospices Civils de Lyon, Bron

74374

NOT_YET_RECRUITING

CH Annecy Genevois site Annecy, Pringy

75010

RECRUITING

Hôpital Saint-Louis, AP-HP, Paris

75651

RECRUITING

GH Pitié Salpêtrière, Paris

76038

RECRUITING

Centre Henri Becquerel, Rouen

80054

RECRUITING

CHU d'Amiens-Picardie Site Sud, Amiens

87042

NOT_YET_RECRUITING

CHU de Limoges, Limoges

92141

NOT_YET_RECRUITING

Hôpital d'Instruction des Armées PERCY, Clamart

92150

NOT_YET_RECRUITING

Hôpital Foch, Suresnes

94805

NOT_YET_RECRUITING

Gustave Roussy, Villejuif

06000

NOT_YET_RECRUITING

CHU de Nice Hôpital Pasteur, Nice

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER