Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients

PHASE2RecruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

July 21, 2021

Primary Completion Date

July 21, 2026

Study Completion Date

July 21, 2026

Conditions
Bone SarcomaOsteosarcoma
Interventions
DRUG

Treatment by regorafenib and best supportive care

"Treatment for 13 cycles (12 months) maximum.~During each cycle :~* patients ≥ 16 years old and patients \<16 old with Body Surface Area (BSA) ≥ 1,70 m2 will take 3 tablets, once a day, corresponding to a total of 120 mg Regorafenib, during 21 days, followed by 7 days without treatment.~* patients \< 16 years old with a 1,30 m2 ≤ BSA ≥ 1,70 m2 will take 2 tablets, once a day, corresponding to a total of 80 mg Regorafenib, during 21 days, followed by 7 days without treatment"

Trial Locations (16)

13385

RECRUITING

Hopital de La Timone, Marseille

21079

NOT_YET_RECRUITING

Centre Georges Francois Leclerc, Dijon

25030

NOT_YET_RECRUITING

Chu Besancon, Besançon

31059

RECRUITING

Iuct Oncopole, Toulouse

33076

RECRUITING

Institut Bergonie, Bordeaux

34298

NOT_YET_RECRUITING

Icm Val D'Aurelle, Montpellier

42270

NOT_YET_RECRUITING

Chu Saint-Etienne, Saint-Priest-en-Jarez

44093

NOT_YET_RECRUITING

Hotel Dieu Nantes, Nantes

44805

RECRUITING

Ico Rene Gauducheau, Saint-Herblain

59020

NOT_YET_RECRUITING

Centre Oscar Lambret, Lille

67098

RECRUITING

CHRU Hôpital Hautepierre, Strasbourg

67200

NOT_YET_RECRUITING

ICANS, Strasbourg

69373

RECRUITING

Centre Leon Berard, Lyon

75005

RECRUITING

Institut Curie, Paris

75014

RECRUITING

Hôpital COCHIN, Paris

94805

NOT_YET_RECRUITING

Institut Gustave Roussy, Villejuif

All Listed Sponsors
lead

Centre Leon Berard

OTHER