204
Participants
Start Date
June 25, 2021
Primary Completion Date
December 31, 2027
Study Completion Date
December 31, 2027
Cladribine (MAVENCLAD®)
"Cladribine (MAVENCLAD®) 3.5mg/kg, administered as weight-adjusted 10mg tablets in two treatment courses (12 months apart) lasting 8- 10 days each.~Cladribine (MAVENCLAD®) 10mg available in blister packs of 1 tablet, 4 tablets and 6 tablets."
Placebo
"Placebo administered as weight adjusted tablets in two treatment courses (12 months apart) lasting 8-10 days each.~Placebo 10mg available in blister packs of 1 tablet, 4 tablets and 6 tablets."
Queens University Belfast (Belfast Health and Social Care Trust), Belfast
University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham
Cardiff University Hospital, Cardiff
University Hospitals of Coventry and Warwickshire NHS Trust, Coventry
Anne Rowling Clinic, University of Edinburgh, Edinburgh
Queen Elizabeth University Hospital Glasgow, Glasgow
University Hospital Hairmyres, NHS Lanarkshire, Glasgow
Leeds Teaching Hospitals NHS Trust, Leeds
Walton Centre NHS Trust, Liverpool
Royal London Hospital, London
Royal Free London NHS Foundation Trust, London
Queen's Hospital (Havering and Redbridge University Hospitals NHS Trust), London
Lewisham and Greenwich NHS Trust, London
St George's University Hospitals NHS Foundation Trust, London
Luton and Dunstable Hospital, Luton
Salford Royal Hospital NHS Trust, Manchester
Aneurin Bevan University Health Board, Newport
Nottingham University Hospital (Nottingham University Hospitals NHS Trust), Nottingham
University Hospitals Plymouth NHS Trust, Plymouth
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield
University Hospitals of North Midlands NHS Trust, Stoke-on-Trent
Morriston Hospital, Swansea, Swansea
National Institute for Health Research, United Kingdom
OTHER_GOV
Merck Serono Limited, UK
INDUSTRY
Multiple Sclerosis Society of Great Britain & Northern Ireland
UNKNOWN
National Multiple Sclerosis Society
OTHER
Barts & The London NHS Trust
OTHER
Queen Mary University of London
OTHER