Effects Magnesium Sulfate and Labetalol Infusion on Peripheral Perfusion and Pain in Nasal Surgeries

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

February 1, 2021

Primary Completion Date

September 1, 2021

Study Completion Date

September 30, 2021

Conditions
Peripheral PerfusionPostoperative Pain
Interventions
DRUG

Magnesium Sulfate Injection

will receive IV bolus dose of 40mg/kg magnesium sulfate in 100 ml saline solution over ten minutes then continuous infusion of 10-15mg/kg/h will be titrated till achieve target mean arterial blood pressure (55-65 mmHg) and will be terminated by the end of surgery.

DRUG

Labetalol Injectable Solution

will receive IV bolus does of labetalol 0.25 mg/kg over ten minutes then continuous infusion of 0.5-1mg/kg/h will be titrated till achieve target mean arterial blood pressure (55-65 mmHg) and will be terminated by the end of surgery.

Trial Locations (1)

002055

Alshaimaa Abdel Fattah Kamel, Zagazig

All Listed Sponsors
lead

Zagazig University

OTHER_GOV

NCT04688203 - Effects Magnesium Sulfate and Labetalol Infusion on Peripheral Perfusion and Pain in Nasal Surgeries | Biotech Hunter | Biotech Hunter