Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

PHASE1RecruitingINTERVENTIONAL
Enrollment

244

Participants

Timeline

Start Date

March 9, 2021

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Interventions
DRUG

T-DXd

T-DXd: administered as an IV infusion

BIOLOGICAL

Durvalumab

Durvalumab: administered as an IV infusion

DRUG

Cisplatin

Cisplatin: administered as an IV infusion

DRUG

Carboplatin

Carboplatin: administered as an IV infusion

DRUG

Pemetrexed

Pemetrexed: administered as an IV infusion (drug not used)

DRUG

Volrustomig

Volrustomig: administered as an IV infusion

DRUG

Rilvegostomig

Rilvegostomig: administered as an IV infusion

Trial Locations (83)

100

RECRUITING

Research Site, Taipei

235

RECRUITING

Research Site, Taipei

333

RECRUITING

Research Site, Taoyuan District

402

RECRUITING

Research Site, Taichung

833

RECRUITING

Research Site, Kaohsiung City

1000

TERMINATED

Research Site, Manila

1015

WITHDRAWN

Research Site, Manila

1100

RECRUITING

Research Site, Quezon City

1112

RECRUITING

Research Site, Quezon City

1500

TERMINATED

Research Site, San Juan City

1634

WITHDRAWN

Research Site, City of Taguig

2650

COMPLETED

Research Site, Edegem

3084

WITHDRAWN

Research Site, Heidelberg

5000

RECRUITING

Research Site, Adelaide

6000

WITHDRAWN

Research Site, Cebu City

6009

RECRUITING

Research Site, Nedlands

6100

RECRUITING

Research Site, Bacolod

6200

RECRUITING

Research Site, Ankara

10029

WITHDRAWN

Research Site, New York

10300

RECRUITING

Research Site, Bangkok

10330

RECRUITING

Research Site, Bangkok

10408

RECRUITING

Research Site, Goyang-si

10450

RECRUITING

Research Site, George Town

10461

WITHDRAWN

Research Site, The Bronx

11217

RECRUITING

Research Site, Taipei

14263

WITHDRAWN

Research Site, Buffalo

20052

RECRUITING

Research Site, Monza

20133

RECRUITING

Research Site, Milan

20162

RECRUITING

Research Site, Milan

21079

RECRUITING

Research Site, Dijon

21287

RECRUITING

Research Site, Baltimore

22031

RECRUITING

Research Site, Fairfax

28041

WITHDRAWN

Research Site, Madrid

28644

RECRUITING

Research Site, Cheongju-si

33075

WITHDRAWN

Research Site, Bordeaux

35100

RECRUITING

Research Site, Bornova-Izmir

35128

RECRUITING

Research Site, Padua

40002

RECRUITING

Research Site, Khon Kaen

40705

RECRUITING

Research Site, Taichung

41013

WITHDRAWN

Research Site, Seville

44800

RECRUITING

Research Site, Saint-Herblain

46010

WITHDRAWN

Research Site, Valencia

48201

WITHDRAWN

Research Site, Detroit

50200

RECRUITING

Research Site, Muang

52620

RECRUITING

Research Site, Tel Litwinsky

52727

RECRUITING

Research Site, Jinju

59100

RECRUITING

Research Site, Kuala Lumpur

62250

RECRUITING

Research Site, Kuala Selangor

66205

WITHDRAWN

Research Site, Westwood

69495

RECRUITING

Research Site, Pierre-Bénite

70403

RECRUITING

Research Site, Tainan City

77030

RECRUITING

Research Site, Houston

80131

RECRUITING

Research Site, Napoli

90110

COMPLETED

Research Site, Hat Yai

91010

WITHDRAWN

Research Site, Duarte

92663

WITHDRAWN

Research Site, Newport Beach

92868

RECRUITING

Research Site, Orange

93586

RECRUITING

Research Site, Kuching

94805

RECRUITING

Research Site, Villejuif

95403

WITHDRAWN

Research Site, Santa Rosa

98405

WITHDRAWN

Research Site, Tacoma

119228

COMPLETED

Research Site, Singapore

168583

COMPLETED

Research Site, Singapore

308433

COMPLETED

Research Site, Singapore

4428164

RECRUITING

Research Site, Kfar Saba

14784-400

NOT_YET_RECRUITING

Research Site, Barretos

90035-903

NOT_YET_RECRUITING

Research Site, Porto Alegre

05652-900

NOT_YET_RECRUITING

Research Site, São Paulo

R3E 0V9

WITHDRAWN

Research Site, Winnipeg

N6A 5W9

WITHDRAWN

Research Site, London

H3T 1E2

RECRUITING

Research Site, Montreal

1066 CX

COMPLETED

Research Site, Amsterdam

PH-8000

TERMINATED

Research Site, Davao City

80-214

RECRUITING

Research Site, Gdansk

30-727

RECRUITING

Research Site, Krakow

10-357

RECRUITING

Research Site, Olsztyn

97-200

TERMINATED

Research Site, Tomaszów Mazowiecki

02-781

RECRUITING

Research Site, Warsaw

03722

RECRUITING

Research Site, Seoul

05505

WITHDRAWN

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

08013

WITHDRAWN

Research Site, Badalona

06800

RECRUITING

Research Site, Ankara

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY

NCT04686305 - Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC | Biotech Hunter | Biotech Hunter