Effect of PDE5 Inhibition on Adipose Metabolism in Humans

PHASE2CompletedINTERVENTIONAL
Enrollment

89

Participants

Timeline

Start Date

March 16, 2021

Primary Completion Date

June 20, 2025

Study Completion Date

June 24, 2025

Conditions
Obesity
Interventions
DRUG

Tadalafil 20 MG

Tadalafil is an FDA approved, clinically-available drug that inhibits the enzyme phosphodiesterase type 5A (PDE5). Subjects who are randomized to this arm will be provided with 20mg of Tadalafil to take every day for 12 weeks, beginning at their baseline visit.

DRUG

Placebo

Subjects in this arm will be provided with 20mg Placebo to take every day for 12 weeks, beginning at their baseline visit.

Trial Locations (1)

37203

Vanderbilt University Medical Center, Nashville

All Listed Sponsors
lead

Vanderbilt University Medical Center

OTHER

NCT04684589 - Effect of PDE5 Inhibition on Adipose Metabolism in Humans | Biotech Hunter | Biotech Hunter