A Study to Assess the Safety and Efficacy of Oral Etrasimod in Adult Participants With Eosinophilic Esophagitis

PHASE2CompletedINTERVENTIONAL
Enrollment

108

Participants

Timeline

Start Date

December 15, 2020

Primary Completion Date

September 30, 2022

Study Completion Date

June 30, 2023

Conditions
Eosinophilic Esophagitis
Interventions
DRUG

Etrasimod

Participants will receive etrasimod tablet by mouth, once daily during the 24-week Double-Blind and 28-week Extension Treatment Periods.

DRUG

Placebo

Participants will receive etrasimod matching placebo tablet by mouth, once daily during the 24-week Double-Blind Treatment Period.

DRUG

Etrasimod

Participants will receive etrasimod tablet by mouth, once daily during the 28-week Extension Treatment Period.

Trial Locations (256)

3011

Footscray Hospital, Footscray

Vision Eye Institute, Melbourne

3076

The Northern Hospital, Epping

3081

MCES Practice Pty Ltd operating as Comprehensive Eye Surgeons (OCT Facility), Bellfield

3124

Retina Specialists Victoria (OCT Facility), Camberwell

3128

Eastern Clinical Research Unit, Box Hill

Eastern Health, Box Hill

3129

Box Hill Eye Surgeons (OCT Facility), Box Hill North

4101

Mater Misericordiae Ltd, Brisbane South

4558

Buderim Eye Centre (OCT Facility), Buderim

Coastal Digestive Health, Maroochydore

4575

Sunshine University Private Hospital, Birtinya

Queensland Respiratory Services ,Pulse Oceanside Medical{PFT Facility ), Birtinya

4740

Dr Shiran DeSilva Respiratory Clinic, Mackay

Mackay Discount Drug Store, Mackay

Mater Misericordiae Hospital, Mackay

Queensland X-Ray, Mackay

Vision Eye Institute Mackay, Mackay

Coral Sea Clinical Research Institute, North Mackay

5092

Modbury Hospital (OCT Facility), Modbury

5112

Elizabeth Specialist Suites (PFT Facility), Elizabeth Vale

Lyell McEwin Hospital., Elizabeth Vale

Lyell McEwin Hospital, Elizabeth Vale

7500

Centre Hospitalier Wallonie Picarde (CHWAPI), Tournai

8091

University Hospital Zurich, Zurich

8310

AZ St Lucas Brugge, Bruges

8800

AZ Delta, Roeselare

12489

Precision for Medicine GmbH, Berlin

17011

West Shore Endoscopy Center, Camp Hill

17043

Penn State Health Medical Group - Lemoyne (PFT only), Lemoyne

17109

Medical Arts Allergy,PC (PFT Only), Harrisburg

17110

Farrel Opthalmology(OCT only), Harrisburg

Susquehanna Research Group, LLC, Harrisburg

17111

Harrisburg Eye Associates (OCT only), Harrisburg

19104

Investigational Drug Services, Philadelphia

University of Pennsylvania, Philadelphia

19610

Berks Center for Digestive Health, Wyomissing

"Berks Schuylkill Respiratory Specialists PFT Procedure Only", Wyomissing

"Eye Consultants of Pennsylvania, PC OCT Procedure Only", Wyomissing

Regional Gastroenterology Associates of Lancaster, Ltd., Wyomissing

19611

Tower Health Reading Hospital, West Reading

23320

Chesapeake Pulmonary and Critical Care Medicine (PFT Only), Chesapeake

Gastroenterology Associates of Tidewater - Endoscopy Center, Chesapeake

Gastroenterology Associates of Tidewater, Chesapeake

23322

Wagner Macula and Retina Center (OCT only), Norfolk

23464

Sleep Specialists of Tidewater - Virginia Beach (PFT Only), Virginia Beach

23502

Wagner Macula and Retina Center (OCT only), Norfolk

24501

Lynchburg Pulmonary Associates, Inc. (PFT only), Lynchburg

24502

Blue Ridge Medical Research, Lynchburg

24551

Harman Eye Center (OCT only), Forest

27278

UNC Gastroenterology at Hillsborough, Hillsborough

27514

lnvestigational Drug Services, University of North Carolina Hospitals (IP storage address), Chapel Hill

UNC Clinical Research Eastowne, Chapel Hill

UNC Hospitals Pulmonary Function Lab (PFT and DLCO procedures only), Chapel Hill

University of North Carolina - Memorial Hospital, Chapel Hill

27517

UNC Endoscopy Center at Meadowmont, Chapel Hill

UNC Hospitals Pulmonary Specialty Clinic (PFT and DLCO procedures only), Chapel Hill

UNC Kittner Eye Center (OCT procedure only), Chapel Hill

27617

Brier Creek Medical Pavilion, Raleigh

27704

Duke Medical Plaza North Duke Street, Durham

27705

Duke Eye Center, Durham

27710

Duke University Medical Center, Durham

Investigational Drug Services (Pharmacy), Durham

28006

Hospital Universitario de La Princesa, Madrid

28304

Coastal Research Institute, Fayetteville

Cumberland Research Associates, LLC, Fayetteville

30030

Georgia Eye Partners, Decatur

30033

Atlanta Center for Gastroenterology, P.C., Decatur

Atlanta Endoscopy Center LTD, Decatur

Pulmonary & Sleep Specialist, Decatur

30309

Digestive Healthcare of Georgia, Atlanta

Peachtree Allergy and Asthma Clinica - Pulmonary Function Test, Atlanta

Piedmont Hospital- DLCO, Atlanta

30324

Ross Eyecare - Opthalmoscopy and OCT, Atlanta

33012

Advanced Eye Center, Hialeah

33134

Beraja Medical Institute (OCT), Coral Gables

The Endoscopy Center (Endoscopy Procedure), Miami

33137

Research Associates of South Florida, Miami

33156

Research Associates of South Florida, Miami

33173

Juan Barrio, MD (PFT when needed), Miami

33458

Jupiter Outpatient Surgery Center, Jupiter

33472

RecioMed Clinical Research Network, Inc, Boynton Beach

33579

Florida Eye Specialists and Cataract Institute, Riverview

33613

Ambulatory Surgery Center, Tampa

Pulmonology & Sleep Disorders, Tampa

33756

Bay Area Chest Physicians, P.A., - Pulmonary Function Test, Clearwater

West Coast Endoscopy Center, Clearwater

West Coast Endoscopy, Clearwater

33761

MACULA CENTER Dana M. Deupree, M.D., F.A.C.S (OCT), Clearwater

Northwood Vision Optical Coherence Tomography (OCT), Clearwater

Safety Harbor Surgery Center, Clearwater

33762

Gastro Florida (Regulatory & Administrative Duties), Clearwater

33812

Central Florida Sleep Diagnostic & Treatment Center, Lakeland

33813

Auzmer Research, Lakeland

33870

Dr. Dennis Bassetti, MD, Sebring

Highlands Eye Institute, P.A., Sebring

The Surgery and Endoscopy Center, Sebring

33884

Day Surgery Center, Winter Haven

34203

Steelgate, Bradenton

34428

Bayfront Health Seven Rivers (Liver Biopsy Location), Crystal River

34429

Citrus Surgery and Endoscopy Center (EGD Location), Crystal River

34452

Nature Coast Clinical Research, Inverness

West Coast Eye Institute (OCT Procedure Only), Inverness

34453

Suncoast Endoscopy Center (EGD Location), Inverness

West Coast Eye Institute (OCT Procedure Only), Lecanto

35209

Clinical Research Center of Alabama, LLC, Birmingham

35216

Alabama Eye MD, Vestavia Hills

35235

GastroHealth - St. Vincent's East, Birmingham

35758

Madison Surgery Center, Madison

35802

Avant Research Associates, LLC, Huntsville

Crestwood Medical Center, Huntsville

35803

Baily Cove Eye Care, Huntsville

36301

Digestive Health Specialists, Dothan

Dothan Eyecare - Dr. Brent McKinley (OCT Procedure Only), Dothan

Dothan Surgery Center (Colonoscopy Location), Dothan

Pulmonary Associates (PFT Procedure Only, Second Location ), Dothan

36305

Flowers Hospital (PFT Procedure Only), Dothan

37204

Vanderbilt GI Endoscopy Lab at One Hundred Oaks, Nashville

37232

Vanderbilt Eye Institute, Nashville

Vanderbilt Pulmonary Medicine, Nashville

Vanderbilt University Medical Center - Digestive Disease Center, Nashville

Vanderbilt University Medical Center - Heart Station, Nashville

37604

Franklin Woods Community Hospital (PFT Only), Johnson City

Pulmonary Associates of ET/Jeff Farrow, MD - PFT only, Johnson City

37660

The Regional Eye Center - OCT only, Kingsport

37663

Tri-Cities Gastroenterology, Kingsport

43016

Ohio Gastroenterology Group, Dublin

43213

Erdey Searcy Eye Group, Columbus

44024

Geauga Sleep Center (PFT Only), Chardon

44060

Great Lakes Medical Research, LLC, Mentor

The Endoscopy Center of Lake County, Mentor

44077

Vitreo Retinal Consultants (OCT only), Painesville

44094

Lake Pulmonary Associates (PFT only), Willoughby

Retina Specialists of Ohio(OCT only), Willoughby Hills

45209

Leon A. Reid, III, M.D. (OCT), Cincinnati

45219

Cincinnati Eye Institute (ophthalmic and OCT exams), Cincinnati

Consultants for Clinical Research, Cincinnati

Gastro Health Research, Cincinnati

Ohio GI and Liver Institute, Cincinnati

Tristate Endoscopy Center (Endoscopy), Cincinnati

UC Health Hoxworth (ophthalmic and OCT only), Cincinnati

UC Health Physicians Office Clifton (where subjects seen), Cincinnati

UC Health Pulmonary (PFT Location), Cincinnati

University of Cincinnati Medical Center Diagnostic Center (Endoscopy location), Cincinnati

45229

UC Health Pulmonary (Pulmonary Function Testing), Cincinnati

45236

Leon A. Reid, III, M.D. (OCT), Cincinnati

45242

New Horizons Clinical Research (PFT), Cincinnati

University Endoscopy Center (Endoscopy location), Cincinnati

45267

UC Health/Division of Digestive Diseases (where subjects seen), Cincinnati

47130

Clark Memorial Health (PFTs), Jeffersonville

One Anesthesia, AACC Division, Jeffersonville

47150

Baptist Health Floyd (PFTs), New Albany

Gastroenterology Health Partners, PLLC, (IP), New Albany

John Kenyon Eye Center (OCT), New Albany

One Anesthesia, PLLC, New Albany

Physicians Medical Center (Endoscopies), New Albany

50009

Hospital Universitario Miguel Servet, Zaragoza

55455

M Health Fairview Clinics and Surgery Center, Minneapolis

M Health Fairview University of Minnesota Medical Center, Minneapolis

University of Minnesota Health Clinical research unit, Minneapolis

University of Minnesota Health Opthalmology Clinic, Minneapolis

55905

Mayo Clinic, Rochester

57701

Rapid City Medical Center, LLP, Rapid City

60026

Glen Endoscopy Center (Endoscopy Facility), Glenview

60031

GI Alliance (PFT), Gurnee

Illinois Gastroenterology Group-Gurnee (Patients Seen; IP Delivered), Gurnee

Medical Eye Services LTD (Ophthalmoscopy with OCT), Gurnee

60044

North Shore Endoscopy Center (Endoscopy), Lake Bluff

60048

Libertyville Imaging Center (Diagnostic Imaging), Libertyville

60611

Northwestern University Feinberg School of Medicine, Chicago

66219

Quest, Lenexa

66606

Cotton O'Neil Clinic (OCT Procedure Only), Topeka

Cotton O'Neil Clinic (PFT Procedure Only), Topeka

Cotton O'Neil Clinical Research Center, Digestive Health, Topeka

68502

Celerion, Inc., Lincoln

70503

Acadiana Endoscopy Center, Inc, Lafayette

Acadiana Gastroenterology Associates, Lafayette

Combined Gastro Research, LLC, Lafayette

Gastroenterology Clinic of Acadiana (IP address), Lafayette

Lafayette General Endoscopy Center, Lafayette

70508

Lafayette Family Eye Care, Lafayette

72205

Little Rock Eye Clinic, Little Rock

72211

Four Seasons Allergy and Asthma, Little Rock

72212

Applied Research Center of Arkansas, Little Rock

Premier Gastroenterology Endoscopy Center, Little Rock

Premier Gastroenterology, Little Rock

73071

Norman Endoscopy Center, Norman

73112

Digestive Disease Specialists, Inc. Endoscopy Lab, Oklahoma City

Digestive Disease Specialists, Inc., Oklahoma City

Pulmonary Physicians of Oklahoma, Oklahoma City

Retinal Center of Oklahoma, Oklahoma City

73118

Central Sooner Research, Oklahoma City

73120

Johnston Eye, Oklahoma City

75074

The Eye Place Jenny Fan, OD (OCT Only), Plano

75082

Pulmonary Medicine Consultants (PFT with DCLO only), Richardson

75231

Digestive Health Center (Endoscopy), Dallas

77054

Precision for Medicine, Houston

77598

Bay Area Houston Endoscopy Center (Endoscopy), Webster

Coastal Eye Associates (OCT), Webster

GI Alliance (Patients Seen), Webster

Houston Lung and Sleep Clinic, PA (PFT), Webster

78130

CHRJSTUS Santa Rosa Physicians Ambulatory Surgery Center-new Braunfels(Endoscopy), New Braunfels

Tyrus Schroeder (PFT), New Braunfels

78666

Advanced Imaging, San Marcos

Central Texas Eye Center (OCT), San Marcos

CHRJSTUS Santa Rosa Physicians Ambulatory Surgery Center - San Marcos (Endoscopy), San Marcos

83404

Grand Teton Research Group, PLLC, Idaho Falls

Grand Teton Surgical Center, Idaho Falls

Idaho Falls Pulmonary/ Sleep and Critical Care Specialists (PFT procedure only), Idaho Falls

Premier Eye Care of Eastern Idaho (OCT procedure only), Idaho Falls

84108

University of Utah Gastroenterology Division Research, Salt Lake City

84112

Huntsman Cancer Hospital, Salt Lake City

84132

University of Utah Hospital, Salt Lake City

University Of Utah School Of Medicine, Salt Lake City

85351

Arizona Digestive Health - Sun City, Sun City

Sun City Endoscopy Center (Endoscopy), Sun City

85381

Arizona Retina Institute/ Phoenix Retina Associates(OCT), Peoria

SimonMed Imaging (Imaging), Peoria

90033

Clinical Trials Unit, Los Angeles

Keck Hospital of USC, Los Angeles

USC IDS Pharmacy, Los Angeles

90067

Advanced Vision Care (OCT), Los Angeles

92532

Inland Pulmonary Specialists [PFT Only], Lake Elsinore

92562

United Surgery Center Murrieta [Endoscopy Only], Murrieta

92563

United Medical Doctors, Murrieta

92591

California Eye Professionals [OCT Only], Temecula

92592

United Surgery Center Temecula [Endoscopy Only], Temecula

92708

Isight Vision Care, Fountain Valley

Mile Square Surgery Center, Fountain Valley

Pulmonary & Sleep Consultants, Fountain Valley

92840

Paragon Rx Clinical, Inc., Garden Grove

93534

Advanced Endoscopy and Pain Center - EGD & Biopsy Collection, Lancaster

Advanced Endoscopy and Pain Center, Lancaster

Antelope Valley Eye Care - OCT, Lancaster

Antelope Valley Eye Care, Lancaster

Antelope Valley Lung and Sleep Institute, Lancaster

Apollo Surgery Center, Lancaster

AV Pediatrics, Allergy and Family Medicine - PFT, Physical Exams, Lab Reviews, ECG Reviews, Lancaster

Gastro Care Institute, Lancaster

Jatinder S. Pruthi, MD FACG CPI - Physical Exams, Lab Reviews, ECG Reviews, Lancaster

Om Research LLC, Lancaster

08723

Del Negro & Senft Eye Associates, Brick

08724

Allied Health Clinical Research Organization, LLC (IP Address), Brick

Seashore Surgical Institute, Brick

Shore Pulmonary, PA, Brick

07728

Allied Health Clinical Research Organization, LLC, Freehold

07753

Del Negro & Senft Eye associates, Neptune City

07701

Del Negro & Senft eye Associates, Red Bank

27599-7064

Clinical and Translational Research Center Outpatient Unit, Chapel Hill

37212-1610

Vanderbilt University Medical Center - GI Research Office, Nashville

37232-5543

Vanderbilt University Medical Center GI Endoscopy Lab, Nashville

M5G 1X5

Mount Sinai Services Inc. Dr George Charames, Toronto

1105 AZ

Amsterdam UMC, location AMC, Amsterdam

03010

Hospital General Universitario de Alicante, Alicante

CH-8091

Universitätsspital Zürich, Zurich

Universtätsspital Zürich, Zurich

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Arena is a wholly owned subsidiary of Pfizer

INDUSTRY

lead

Pfizer

INDUSTRY

NCT04682639 - A Study to Assess the Safety and Efficacy of Oral Etrasimod in Adult Participants With Eosinophilic Esophagitis | Biotech Hunter | Biotech Hunter