282
Participants
Start Date
April 22, 2021
Primary Completion Date
May 5, 2023
Study Completion Date
May 5, 2023
Normobaric Hyperoxia
Within 6 hours after stroke onset, patients were randomized into the NBO group and immediately given 100% oxygen inhalation (no more than 30 minutes after randomization) at a ventilation rate of 10L/ min using a sealed non-ventilating oxygen storage mask and keep giving oxygen for 4 hours. If the patient needs to be intubated with a ventilator to maintain ventilation, the FiO2 should be set to 1.0.
Sham Normobaric Hyperoxia
For Sham NBO group, Patients were immediately given oxygen inhalation (no more than 30 minutes after randomization) at a ventilation rate of 1l/min using the same mask and keep giving oxygen for 4 hours. If the patient needs to be intubated with a ventilator to maintain, the FiO2 should be set to 0.3 and gradualy incerased if spO2≤94%；
Endovascular Thrombectomy
EVT is the international guidelines for the treatment of acute ischemic stroke with lage vessel occlusion.
Xuan Wu Hospital，Capital Medical University, Beijing
Tianjin Huanhu Hospital
OTHER
Shengli Oilfield Hospital
OTHER
Beijing Fengtai You'anmen Hospital
UNKNOWN
Jiujiang University Affiliated Hospital
OTHER_GOV
Zhangzhou Municipal Hospital of Fujian Province
OTHER
Baotou Central Hospital
OTHER
Luoyang Central Hospital
OTHER
Nanyang Central Hospital
OTHER
Qingdao Central Hospital
OTHER
The Third People's Hospital of Jinan
UNKNOWN
Rizhao People's Hospital
OTHER
Anyang People's Hospital
UNKNOWN
Shanghai 10th People's Hospital
OTHER
Dalian Municipal Central Hospital
OTHER
Zhoukou Central Hospital
OTHER
Nanshi Hospital of Nanyang
UNKNOWN
The second Nanning People's Hospital
UNKNOWN
Zhumadian Central Hospital
OTHER
Taizhou Hospital
OTHER
Second Affiliated Hospital of Nanchang University
OTHER
Capital Medical University
OTHER