225
Participants
Start Date
March 25, 2021
Primary Completion Date
January 20, 2035
Study Completion Date
January 20, 2036
Melphalan or Melphalan + Topotecan
IAC: 2-6 cycles every 1 month (number based on the local tumor evolution), performed using radio-guided catheterization and delivery at the ostium of the ophthalmic artery, in neuroradiology operating room, and under General Anesthesia (GA). IAC will be administered at the Fondation Rothschild Hospital in collaboration with the Interventional Neuroradiology team.
etoposide, carboplatin and vincristine or local ophthalmological treatment without IV chemotherapy
2 to 6 cycles of combined etoposide, carboplatin and vincristine or local ophthalmological treatment without IV chemotherapy : thermotherapy and/or cryotherapy and/or iodine-125 plaques and/or intravitreal chemotherapy injections
Carboplatin administered on Day 1
Chemothermotherapy : Intravenous injection by carboplatin
Thermotherapy (local treatment)
Thermotherapy after carboplatin administered on Day 1
Cryotherapy (local treatment)
Cryotherapy (local treatment)
Iodine-125 plaques (local treatment)
Iodine-125 plaques (local treatment)
Intravitreal Melphalan chemotherapy injections (local treatment)
Intravitreal Melphalan chemotherapy injections (local treatment)
RECRUITING
Marseille Chu, Marseille
RECRUITING
CAEN CHU, Caen
RECRUITING
DIJON CHU Hopital François Mitterand, Dijon
RECRUITING
BESANCON CHU Hopital Jean Minjoz, Besançon
RECRUITING
BREST CHRU Hopital Morvan, Brest
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Toulouse Chu, Toulouse
RECRUITING
Bordeaux Chu, Bordeaux
RECRUITING
MONTPELLIER CHU Hopital Arnaud De Villeneuve, Montpellier
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Rennes Chu, Rennes
RECRUITING
TOURS CHU Hopital Clocheville, Tours
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Grenoble Chu, Grenoble
RECRUITING
Saint Etienne Chu, Saint-Etienne
RECRUITING
NANTES CHU Hopital Mere-Enfant, Nantes
RECRUITING
Angers Chu, Angers
RECRUITING
Reims Chu, Reims
RECRUITING
Nancy Chu, Vandœuvre-lès-Nancy
RECRUITING
LILLE Centre Oscar Lambret, Lille
RECRUITING
CHU ESTAING Centre Régional de Cancérologie et Therapie Cellulaire Pediatrique (CRCTCP), Clermont-Ferrand
RECRUITING
Strasbourg Chu, Strasbourg
RECRUITING
LYON Centre Léon Bérard, Lyon
RECRUITING
Institut Curie, Paris
RECRUITING
PARIS Fondation Ophtalmologique Adolphe de Rothschild, Paris
RECRUITING
Rouen Chu, Rouen
RECRUITING
Amiens Chu, Amiens
RECRUITING
Poitiers Chu, Poitiers
RECRUITING
Limoges Chu, Limoges
RECRUITING
La Reunion - Chr Felix Guyon, Saint-Denis
RECRUITING
NICE CHU Hopital Archet 2, Nice
Fondation Rothschild Paris
OTHER
Institut Curie
OTHER