suPAR-Guided Anakinra Treatment for Management of Severe Respiratory Failure by COVID-19

PHASE3CompletedINTERVENTIONAL
Enrollment

606

Participants

Timeline

Start Date

December 23, 2020

Primary Completion Date

March 31, 2021

Study Completion Date

February 6, 2022

Conditions
Covid19
Interventions
DRUG

Anakinra

Standard-of-care and anakinra. Anakinra is injected subcutaneously as 100 mg once daily for 10 days

DRUG

Placebo

Standard-of-care and placebo. Placebo is injected subcutaneously once daily for 10 days

Trial Locations (40)

Unknown

2nd Department of Internal Medicine, University General Hospital of Alexandroupolis, Alexandroupoli

10th Department of Pulmonary Medicine, SOTIRIA General Hospital of Chest Diseases of Athens, Athens

1st Department of Internal Medicine, AMALIA FLEMING Prefecture General Hospital of Melissia, Athens

1st Department of Internal Medicine, General Hospital of Athens KORGIALENIO-BENAKIO E.E.S., Athens

1st Department of Internal Medicine, General Hospital of Eleusis THRIASIO, Athens

1st Department of Internal Medicine, General Hospital of Nea Ionia CONSTANTOPOULIO-PATISION, Athens

1st Department of Internal Medicine, General Hospital of Voula ASKLEPIEIO, Athens

1st University Department of Internal Medicine, General Hospital of Athens LAIKO, Athens

1st University Department of Pulmonary Medicine, SOTIRIA General Hospital of Chest Diseases of Athens, Athens

2nd Department of Internal Medicine, General Hospital of Eleusis THRIASIO, Athens

2nd Department of Pulmonary Medicine, SOTIRIA General Hospital of Chest Diseases of Athens, Athens

2nd University Department of Internal Medicine, IPPOKRATEION General Hospital of Athens, Athens

3rd Department of Internal Medicine, General Hospital of Athens KORGIALENEIO-BENAKEIO E.E.S., Athens

3rd University Department of Internal Medicine, General Hospital of Chest Diseases of Athens SOTIRIA, Athens

4th Department of Internal Medicine, ATTIKON University General Hospital, Athens

4th Department of Pulmonary Medicine, SOTIRIA General Hospital of Chest Diseases of Athens, Athens

5th Department of Pulmonary Medicine, SOTIRIA General Hospital of Chest Diseases of Athens, Athens

COVID-19 Department, General Hospital of Attica SISMANOGLEIO-AMALIA FLEMING, Athens

Department of Clinical Therapeutics, ALEXANDRA General Hospital of Athens, Athens

Department of COVID-19, Evangelismos General Hospital, Athens

Department of Internal Medicine, General Hospital of Athens Elpis, Athens

• 1st Department of Internal Medicine, General Hospital of Athens G. GENNIMATAS, Athens

• Department of Internal Medicine, General Hospital of Chest Diseases of Athens SOTIRIA, Athens

Department of Pulmonary Medicine, General Hospital of Kerkyra, Corfu

1st Department of Internal Medicine, General University Hospital of Ioannina, Ioannina

Department of Internal Medicine, University General Hospital of Larissa,, Larissa

Department of Internal Medicine, University General Hospital of Patras PANAGIA I VOITHIA, Pátrai

2nd Department of Internal Medicine, General Hospital of Piraeus TZANEIO, Piraeus

1st Department of Internal Medicine, AHEPA University General Hospital of Thessaloniki, Thessaloniki

1st Department of Internal Medicine, PAPAGEORGIOU General Hospital of Thessaloniki, Thessaloniki

2nd Department of Propedeutic Medicine, Ippokrateion University General Hospital of Thessaloniki, Thessaloniki

3rd University Department of Internal Medicine, PAPAGEORGIOU General Hospital of Thessaloniki, Thessaloniki

Dipartimento di Medicina Dipartimento di Malattie Infettive, ASST Spedali civili, Brescia

Unità Operativa Clinica Malattie Infettive, Ospedale Policlinico San Martino, Genova

Dipartimento di Medicina Interna, Istituto Clinico Humanitas, Milan

Medicina Interna, Reumatologia, Immunologia, IRCCS San Raffaele, Milan

Dipartimento di Malattie Infettive e Tropicali e Microbiologia, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar

Dipartimento di Malattie Infettive ad alta Intensità di cura ed altamente contagiose, IRCCS Lazzaro Spallanzani, Roma

Dipartimento Scienze di laboratorio e infettivologiche, Policlinico Universitario Agostino Gemelli, Roma

Dipartimento di Malattie infettive e tropicali-Università dell'Insubria, ASST dei Sette Laghi, Varese

All Listed Sponsors
lead

Hellenic Institute for the Study of Sepsis

OTHER

NCT04680949 - suPAR-Guided Anakinra Treatment for Management of Severe Respiratory Failure by COVID-19 | Biotech Hunter | Biotech Hunter