Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) [MK-7902-007/E7080-G000-314/LEAP-007] - China Extension Study

PHASE3CompletedINTERVENTIONAL
Enrollment

107

Participants

Timeline

Start Date

October 23, 2019

Primary Completion Date

May 19, 2021

Study Completion Date

March 29, 2024

Conditions
Non-small Cell Lung Cancer
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion

DRUG

Lenvatinib

oral capsule

DRUG

Placebo for lenvatinib

oral capsule

Trial Locations (17)

100006

Peking Union Medical College Hospital ( Site 0105), Beijing

100036

Beijing Cancer Hospital ( Site 0102), Beijing

101149

Beijing Chest Hospital Capital Medical University ( Site 0111), Beijing

130021

The First Hospital of Jilin University ( Site 0110), Changchun

200030

Shanghai Chest Hospital ( Site 0112), Shanghai

200032

Zhongshan Hospital Fudan University ( Site 0100), Shanghai

210009

Jiangsu Cancer Hospital ( Site 0101), Nanjing

230001

Anhui Provincial Hospital ( Site 0108), Hefei

230088

The First Affiliated Hospital of Anhui Medical University ( Site 0113), Hefei

310003

The First Affiliated Hospital Zhejiang University ( Site 0106), Hangzhou

310006

Hangzhou First People's Hospital ( Site 0109), Hangzhou

310009

2nd Affil Hosp of Zhejiang University College of Medicine ( Site 0114), Hangzhou

310022

Zhejiang Cancer Hospital ( Site 0116), Hangzhou

410008

Xiangya Hospital of Central South University ( Site 0115), Changsha

410013

Hunan Cancer Hospital ( Site 0104), Changsha

710061

1st Affil Hosp of Med College of Xi'an Jiaotong University ( Site 0103), XiAn

18215516050

West China Hospital of Sichuan University ( Site 0117), Chengdu

All Listed Sponsors
collaborator

Eisai Inc.

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04676412 - Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) [MK-7902-007/E7080-G000-314/LEAP-007] - China Extension Study | Biotech Hunter | Biotech Hunter