170
Participants
Start Date
April 22, 2020
Primary Completion Date
March 3, 2021
Study Completion Date
March 3, 2021
2 post-mortem transcutaneous lung biopsies (1 anterior ; 1 posterior) using anatomical landmarks
All specimens are fixed with 4% neutral formaldehyde and embedded in paraffin wax in the department of pathology of each participating centre. Afterwards, all samples are sent for analysis to the department of pathology of Nantes university hospital. All biopsies are independently analysed by a group of pathologists who are experts in lung tissue and blinded to clinical information. All biopsies will be analysed using a predetermined semi-quantitative histological scoring grid. The pathologists are asked to assess the degree of: edema, cell necrosis, hyaline membrane formation, proliferation of alveolar type 2 cells, fibrosis, capillary congestion, alveolar edema, neutrophilic infiltration, and microscopic thrombosis. Finally, the following patterns are recorded: exudative diffuse alveolar damage (DAD), proliferative DAD, fibrosis, intra-alveolar haemorrhage, lymphocytic pneumonia, organizing pneumonia, acute fibrinous organizing pneumonia (AFOP), thrombotic microangiopathy.
Nantes University Hospital, Nantes
CH Amiens, Amiens
Angers University Hospital, Angers
CH Angoulême, Angoulême
CH Annecy, Annecy
Hopital Privé d'Antony, Antony
CH Argenteuil, Argenteuil
CH Belfort, Belfort
CHU Bordeaux, Bordeaux
Hopital Sainte Camille, Bry-sur-Marne
CH Cahors, Cahors
CH Cergy Pontoise, Cergy-Pontoise
CH Cholet, Cholet
CHU Clermont-Ferrand, Clermont-Ferrand
CH Compiègne-Noyon, Compiègne
CHD Vendée, La Roche-sur-Yon
Hopital Lyon Sud, Lyon
Hôpital Lyon Sud, Lyon
Marseille Hopital Nord APHM, Marseillette
CH Melun, Melun
CH Montélimar, Montélimar
CHU Nice, Nice
CHR Orléans, Orléans
CH Ambroise Paré APHP, Paris
GHEF Marne La Vallée, Paris
Hopital Antoine Béclère APHP, Paris
Hopital Cochin APHP, Paris
Hopital Georges Pompidou APHP, Paris
Hopital La Pitié Salpetrière APHP, Paris
Hopital Louis Mourier APHP, Paris
Hopital Necker APHP, Paris
Hopital Saint-Antoine APHP, Paris
Hopital Saint-Louis APHP, Paris
CH Poissy, Poissy
Hopital Privé Claude Galien, Quincy-sous-Sénart
CH Reims, Reims
CHU Rennes, Rennes
CH Saint-Brieuc, Saint-Brieuc
CHU Saint-Etienne, Saint-Etienne
Hopital Foch, Suresnes
CHRU Tours, Tours
CH Troyes, Troyes
CH Vannes, Vannes
CH Versailles, Versailles
National Research Agency, France
OTHER
Nantes University Hospital
OTHER