Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration

1 g of vancomycin will be delivered intravenously over a period of one hour prior to tourniquet inflation.

After exsanguination of the limb and elevation of the tourniquet in the prepped and draped patient, Vancomycin will be injected into a superficial vein in the hand, wrist or forearm.

500 mg diluted in 50 cc normal saline of injection into superficial vein in the hand, wrist or forearm