Rifabutin Versus Rifampicin for Treatment of Staphylococcal PJI Treated With DAIR

PHASE3RecruitingINTERVENTIONAL
Enrollment

436

Participants

Timeline

Start Date

November 8, 2021

Primary Completion Date

November 30, 2026

Study Completion Date

June 30, 2027

Conditions
Prosthetic Infection
Interventions
DRUG

Rifabutin

2 tablets of 150 mg per day rifabutin tablet daily for 12 weeks in 1 administration with a companion treatment

DRUG

Rifampicin

10 mg/kg per day (range 600 mg to 1,200 mg) rifampicin tablet in 1 daily dose for 12 weeks with a companion treatment

Trial Locations (30)

Unknown

NOT_YET_RECRUITING

CHU Amiens Picardie, Amiens

NOT_YET_RECRUITING

CHU Angers, Angers

RECRUITING

CHU Besançon, Besançon

NOT_YET_RECRUITING

CH de Béthune, Béthune

NOT_YET_RECRUITING

CHU Bordeaux, Bordeaux

NOT_YET_RECRUITING

APHP Hôpital Ambroise Paré, Boulogne-Billancourt

RECRUITING

CHRU Brest, Brest

RECRUITING

CHU Caen, Caen

NOT_YET_RECRUITING

CH Alpes Leman, Contamine-sur-Arve

NOT_YET_RECRUITING

CHU Dijon Bourgogne, Dijon

NOT_YET_RECRUITING

CHU Grenoble Alpes, Grenoble

RECRUITING

CHRU Lille, Lille

NOT_YET_RECRUITING

GHICL Hôpital Saint Vincent de Paul, Lille

RECRUITING

CHU de Limoges, Limoges

NOT_YET_RECRUITING

GHICL Hôpital Saint Philibert, Lomme

NOT_YET_RECRUITING

Clinique de la Sauvegarde, Lyon

NOT_YET_RECRUITING

Hospices Civils de Lyon, Lyon

NOT_YET_RECRUITING

APHM Hôpital Nord, Marseille

NOT_YET_RECRUITING

CHU Nice, Nice

RECRUITING

CH Annecy Genevois, Pringy

NOT_YET_RECRUITING

CH Cornouaille, Quimper

NOT_YET_RECRUITING

CHU Reims, Reims

RECRUITING

CHU de Rennes, Rennes

NOT_YET_RECRUITING

CHU Saint Etienne, Saint-Priest-en-Jarez

NOT_YET_RECRUITING

CHRU Strasbourg, Strasbourg

RECRUITING

Hôpital d'instruction des armées Sainte Anne, Toulon

NOT_YET_RECRUITING

Clinique Joseph Ducuing, Toulouse

NOT_YET_RECRUITING

Clinique Médipole Garonne, Toulouse

RECRUITING

CH Tourcoing, Tourcoing

RECRUITING

CHRU Tours, Tours

All Listed Sponsors
lead

Tourcoing Hospital

OTHER