Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

188

Participants

Timeline

Start Date

April 27, 2021

Primary Completion Date

June 30, 2029

Study Completion Date

June 30, 2029

Conditions
Recurrent Head and Neck Squamous Cell CarcinomaRecurrent Hypopharyngeal Squamous Cell CarcinomaRecurrent Laryngeal Squamous Cell CarcinomaRecurrent Oral Cavity Squamous Cell CarcinomaRecurrent Oropharyngeal Squamous Cell Carcinoma
Interventions
DRUG

Carboplatin

Given IV

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Pembrolizumab

Given IV

RADIATION

Proton Beam Radiation Therapy

Undergo PBRT

Trial Locations (170)

10003

RECRUITING

Mount Sinai Union Square, New York

10011

RECRUITING

Mount Sinai Chelsea, New York

10029

RECRUITING

Mount Sinai Hospital, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10461

RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

10467

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

10604

RECRUITING

Memorial Sloan Kettering Westchester, Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau, Uniondale

11725

RECRUITING

Memorial Sloan Kettering Commack, Commack

11794

RECRUITING

Stony Brook University Medical Center, Stony Brook

14580

RECRUITING

Wilmot Cancer Institute at Webster, Webster

14642

RECRUITING

University of Rochester, Rochester

15215

RECRUITING

UPMC-Saint Margaret, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

ACTIVE_NOT_RECRUITING

UPMC-Shadyside Hospital, Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

16105

RECRUITING

UPMC Hillman Cancer Center - New Castle, New Castle

16121

RECRUITING

UPMC Cancer Center at UPMC Horizon, Farrell

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

16601

RECRUITING

UPMC Altoona, Altoona

17408

RECRUITING

UPMC Memorial, York

17822

RECRUITING

Geisinger Medical Center, Danville

17837

RECRUITING

Geisinger Medical Oncology-Lewisburg, Lewisburg

18711

RECRUITING

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

19114

RECRUITING

Jefferson Torresdale Hospital, Philadelphia

19140

ACTIVE_NOT_RECRUITING

Temple University Hospital, Philadelphia

20010

ACTIVE_NOT_RECRUITING

MedStar Washington Hospital Center, Washington D.C.

21044

RECRUITING

Central Maryland Radiation Oncology in Howard County, Columbia

21061

RECRUITING

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

SUSPENDED

Maryland Proton Treatment Center, Baltimore

RECRUITING

University of Maryland/Greenebaum Cancer Center, Baltimore

23235

RECRUITING

VCU Massey Cancer Center at Stony Point, Richmond

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27203

SUSPENDED

Randolph Hospital, Asheboro

27320

RECRUITING

Annie Penn Memorial Hospital, Reidsville

27403

RECRUITING

Cone Health Cancer Center, Greensboro

29425

RECRUITING

Medical University of South Carolina, Charleston

30308

RECRUITING

Emory Proton Therapy Center, Atlanta

RECRUITING

Emory University Hospital Midtown, Atlanta

30322

SUSPENDED

Emory University Hospital/Winship Cancer Institute, Atlanta

31404

SUSPENDED

Memorial Health University Medical Center, Savannah

32610

ACTIVE_NOT_RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33607

SUSPENDED

Moffitt Cancer Center-International Plaza, Tampa

33612

RECRUITING

Moffitt Cancer Center - McKinley Campus, Tampa

RECRUITING

Moffitt Cancer Center, Tampa

35233

SUSPENDED

University of Alabama at Birmingham Cancer Center, Birmingham

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

39216

SUSPENDED

University of Mississippi Medical Center, Jackson

40202

RECRUITING

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

RECRUITING

UofL Health Medical Center Northeast, Louisville

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

45005

ACTIVE_NOT_RECRUITING

Dayton Physicians LLC-Atrium, Franklin

45331

RECRUITING

Miami Valley Cancer Care and Infusion, Greenville

45373

RECRUITING

Upper Valley Medical Center, Troy

45409

RECRUITING

Premier Blood and Cancer Center, Dayton

ACTIVE_NOT_RECRUITING

Greater Dayton Cancer Center, Kettering

45415

ACTIVE_NOT_RECRUITING

Dayton Physician LLC - Englewood, Dayton

RECRUITING

Miami Valley Hospital North, Dayton

45429

ACTIVE_NOT_RECRUITING

Kettering Medical Center, Kettering

45431

ACTIVE_NOT_RECRUITING

Indu and Raj Soin Medical Center, Beavercreek

45459

ACTIVE_NOT_RECRUITING

Dayton Physicians LLC-Miami Valley South, Centerville

RECRUITING

Miami Valley Hospital South, Centerville

47374

ACTIVE_NOT_RECRUITING

Reid Health, Richmond

48109

SUSPENDED

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

ACTIVE_NOT_RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48334

ACTIVE_NOT_RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

Broadlawns Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50316

SUSPENDED

Iowa Lutheran Hospital, Des Moines

50325

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

51503

RECRUITING

Heartland Oncology and Hematology LLP, Council Bluffs

RECRUITING

Methodist Jennie Edmundson Hospital, Council Bluffs

53051

RECRUITING

Froedtert Menomonee Falls Hospital, Menomonee Falls

53095

RECRUITING

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53154

RECRUITING

Drexel Town Square Health Center, Oak Creek

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54701

ACTIVE_NOT_RECRUITING

HSHS Sacred Heart Hospital, Eau Claire

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

56601

RECRUITING

Sanford Joe Lueken Cancer Center, Bemidji

57078

RECRUITING

Avera Cancer Institute at Yankton, Yankton

57105

RECRUITING

Avera Cancer Institute, Sioux Falls

58122

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Logan Health Medical Center, Kalispell

60045

ACTIVE_NOT_RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60153

RECRUITING

Loyola University Medical Center, Maywood

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

60612

RECRUITING

John H Stroger Jr Hospital of Cook County, Chicago

RECRUITING

University of Illinois, Chicago

61801

RECRUITING

Carle Cancer Center, Urbana

SUSPENDED

The Carle Foundation Hospital, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

SUSPENDED

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

63110

ACTIVE_NOT_RECRUITING

Washington University School of Medicine, St Louis

63128

RECRUITING

Mercy Hospital South, St Louis

63129

ACTIVE_NOT_RECRUITING

Siteman Cancer Center-South County, St Louis

63136

ACTIVE_NOT_RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

ACTIVE_NOT_RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

RECRUITING

Mercy Hospital Saint Louis, St Louis

63376

ACTIVE_NOT_RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

SUSPENDED

Saint Francis Medical Center, Cape Girardeau

64064

ACTIVE_NOT_RECRUITING

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

ACTIVE_NOT_RECRUITING

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

ACTIVE_NOT_RECRUITING

University of Kansas Cancer Center - North, Kansas City

65804

SUSPENDED

Mercy Hospital Springfield, Springfield

66160

ACTIVE_NOT_RECRUITING

University of Kansas Cancer Center, Kansas City

66205

ACTIVE_NOT_RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

ACTIVE_NOT_RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

66211

ACTIVE_NOT_RECRUITING

University of Kansas Hospital-Indian Creek Campus, Overland Park

68114

RECRUITING

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC, Omaha

RECRUITING

Nebraska Methodist Hospital, Omaha

SUSPENDED

Oncology Associates PC, Omaha

72205

RECRUITING

University of Arkansas for Medical Sciences, Little Rock

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

73505

RECRUITING

Cancer Centers of Southwest Oklahoma Research, Lawton

84112

ACTIVE_NOT_RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

90027

RECRUITING

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90706

RECRUITING

Kaiser Permanente-Bellflower, Bellflower

91761

RECRUITING

Kaiser Permanente-Ontario, Ontario

92093

ACTIVE_NOT_RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92121

ACTIVE_NOT_RECRUITING

California Protons Cancer Therapy Center, San Diego

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92806

RECRUITING

Kaiser Permanente-Anaheim, Anaheim

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95661

ACTIVE_NOT_RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

ACTIVE_NOT_RECRUITING

Sutter Roseville Medical Center, Roseville

97015

SUSPENDED

Clackamas Radiation Oncology Center, Clackamas

SUSPENDED

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

06510

RECRUITING

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

RECRUITING

Yale University, New Haven

06611

RECRUITING

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06385

RECRUITING

Smilow Cancer Hospital Care Center - Waterford, Waterford

50266-7700

SUSPENDED

Methodist West Hospital, West Des Moines

02111

RECRUITING

Tufts Medical Center, Boston

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth, Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen, Montvale

45005-1066

RECRUITING

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54235-1495

RECRUITING

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH