120
Participants
Start Date
December 10, 2020
Primary Completion Date
October 12, 2022
Study Completion Date
May 5, 2024
Autoantibody ELISA
Serum will be tested for novel autoantibodies against candidate auto-antigens by ELISA, such as those previously identified as of importance (e.g. eosinophil peroxidase, EPX) and also novel candidate proteins specific to eosinophils as identified by FANTOM5 geneset analysis.
Granulocyte Immunofluorescence
The presence of auto-antibodies in patient serum to inactive and activated neutrophils / eosinophils, with and without post-translational modification, will be examined by indirect immunofluorescence.
Barts Health NHS Trust, Dept of Rheumatology, Mile End Hospital, London
Barts Health NHS Trust, Dept of Respiratory Medicine, St Bartholomew's Hospital, London
Queen Mary University of London
OTHER