Phase II-III Clinical Trial of PD1 Antibody (Toripalimab), Lenvatinib and GEMOX Neoadjuvant Treatment for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

178

Participants

Timeline

Start Date

January 20, 2021

Primary Completion Date

April 30, 2025

Study Completion Date

December 31, 2026

Conditions
Intrahepatic CholangiocarcinomaPD1 AntibodyLenvatinibGemox Chemotherapy
Interventions
DRUG

Neoadjuvant treatment

PD1 antibody (Toripalimab) combined with GEMOX chemotherapy and Lenvatinib neoadjuvant treatment

Trial Locations (1)

200032

Zhongshan hospital, Shanghai

All Listed Sponsors
collaborator

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

collaborator

Shanghai Public Health Clinical Center

OTHER_GOV

collaborator

RenJi Hospital

OTHER

collaborator

Shenzhen University General Hospital

OTHER

collaborator

Sir Run Run Shaw Hospital

OTHER

collaborator

Tang-Du Hospital

OTHER

collaborator

First Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

collaborator

The First Affiliated Hospital of Anhui Medical University

OTHER

collaborator

First Hospital of China Medical University

OTHER

collaborator

Eastern Hepatobiliary Surgery Hospital

OTHER

collaborator

First Affiliated Hospital Xi'an Jiaotong University

OTHER

collaborator

Shanghai Jiao Tong University Affiliated Sixth People's Hospital

OTHER

collaborator

First Affiliated Hospital of Guangxi Medical University

OTHER

collaborator

The Affiliated Hospital of Qingdao University

OTHER

collaborator

Peking Union Medical College Hospital

OTHER

collaborator

Meng Chao Hepatobiliary Hospital of Fujian Medical University

OTHER

collaborator

The First Affiliated Hospital of University of Science and Technology of China

OTHER

collaborator

Cancer Hospital of Guangxi Medical University

OTHER

collaborator

Tongji Hospital

OTHER

collaborator

Zhejiang Provincial People's Hospital

OTHER

collaborator

The Second Affiliated Hospital of Kunming Medical University

OTHER

collaborator

Sichuan Provincial People's Hospital

OTHER

collaborator

Taizhou Hospital

OTHER

collaborator

Shaoxing People's Hospital

OTHER

collaborator

The First Hospital of Hebei Medical University

OTHER

lead

Shanghai Zhongshan Hospital

OTHER