TL-895 and KRT-232 Study in Acute Myeloid Leukemia

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

March 31, 2021

Primary Completion Date

November 30, 2024

Study Completion Date

November 30, 2025

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

TL-895

TL-895 is an experimental tyrosine kinase inhibitor anticancer drug taken by mouth.

DRUG

KRT-232

KRT-232 is an experimental MDM2 inhibitor anticancer drug taken by mouth.

Trial Locations (35)

1090

Medical University Vienna, Department of Internal Medicine I, Clinical Department of Hematology and Hemostaseology, Vienna

2145

Westmead Hospital, Sydney

4020

Ordensklinikum Linz GmbH Elisabethinen, Linz

4556

University of Sunshine Coast-Sippy Downs, Sippy Downs

10065

Weill Cornell Medical College, New York

13009

Paoli-Calmettes Institute, Marseille

19107

Thomas Jefferson University, Sidney Kimmel Cancer Center, Clinical Research Organization, Philadelphia

20246

University Hospital Hamburg-Eppendorf, Department of Internal Medicine II, Hamburg

21565

Gachon University Gil Medical Center, Incheon

30625

Hannover Medical School, Center for Internal Medicine, Clinic of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hanover

30912

Georgia Cancer Center, Augusta

40138

Polyclinic S. Orsola-Malpighi, Operative Unit of Hematology, Bologna

44000

University Hospital of Nantes, Nantes

45147

University Duisburg-Essen, University Hospital Essen, Department of Internal Medicine, Essen

45219

University of Cincinnati, Cincinnati

46010

University Clinical Hospital of Valencia, Department of Hematology and Medical Oncology, Valencia

46026

Hospital Universitario y Politécnico de La Fe, Valencia

47014

Romagnolo Scientific Institute of Meldola (IRST) S.r.l., Department of Oncology and Clinical and Experimental Haematology, Meldola

48178

South Lyon Hospital Center, Lyon

48201

Karmanos Cancer Institute, Detroit

59037

Claude Huriez Hospital, Lille

60126

University Hospital - Ospedali Riuniti Umberto I - GM Lancisi - G Salesi of Ancona, Haematology Clinic, Ancona

60611

Northwestern Memorial Hospital, Chicago

60612

Rush University Medical Center, Division of Hematology Oncology and Cell Therapy, Chicago

75010

Saint-Louis Hospital, Paris

75390

UT Southwestern Medical Center, Harold C. Simmons Cancer Center, Dallas

90033

Keck School of Medicine, Los Angeles

92868

University of California, Irvine Medical Center, Orange

98109

Seattle Cancer Care Alliance, Seattle

06000

Hospital Center Universitaire De Nice, Nice

06120

University Hospital Halle (Saale), Department of Internal Medicine IV - Hematology and Oncology, Halle

07747

University Hospital Jena, Clinic of Internal Medicine II, Department of Hematology and Medical Oncology, Jena

03080

Seoul National University Hospital, Department of Hemato-Oncology, Seoul

08916

University Hospital Germans Trias i Pujol, Department of Clinical Hematology, Badalona

08035

University Hospital Vall d'Hebron, Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Kartos Therapeutics, Inc.

INDUSTRY

lead

Telios Pharma, Inc.

INDUSTRY

NCT04669067 - TL-895 and KRT-232 Study in Acute Myeloid Leukemia | Biotech Hunter | Biotech Hunter