Noninvasive Ventilation in Moderate-to-severe COVID-19-associated Acute Respiratory Distress-syndrome

CompletedOBSERVATIONAL
Enrollment

80

Participants

Timeline

Start Date

October 1, 2020

Primary Completion Date

June 30, 2021

Study Completion Date

August 31, 2021

Conditions
Covid19ARDS
Interventions
DIAGNOSTIC_TEST

Respiratory monitoring

Measurement of the tidal volume, peak inspiratory flow, inspiratory time, respiratory rate and the pressure gap during triggering on NIV and plateau pressure on mechanical ventilation

DIAGNOSTIC_TEST

Respiratory muscles ultrasound

Measurement of the diaphragm thickening fraction, assessment of the contraction of scalene and sternocleidomastoid muscles

DIAGNOSTIC_TEST

Electro impedance tomography

Measurement of the lung impedance changes in 4 quadrants, measurement of regional ventilation delay in 4 quadrants

DIAGNOSTIC_TEST

Capnography

Measurement of end-tidal carbon dioxide tension

DIAGNOSTIC_TEST

Arterial blood gas

Measurement of the oxygen partial pressure and the carbon dioxide partial pressure

DIAGNOSTIC_TEST

Quasistatic pressure-volume curve

Quasistatic pressure-volume curve

Trial Locations (1)

Unknown

Sechenov University clinic #4, Moscow

All Listed Sponsors
lead

I.M. Sechenov First Moscow State Medical University

OTHER

NCT04667923 - Noninvasive Ventilation in Moderate-to-severe COVID-19-associated Acute Respiratory Distress-syndrome | Biotech Hunter | Biotech Hunter