A Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Participants With Recurrent/Metastatic PD-L1 Positive Squamous Cell Carcinoma of the Head and Neck

PHASE2CompletedINTERVENTIONAL
Enrollment

123

Participants

Timeline

Start Date

March 2, 2021

Primary Completion Date

September 20, 2023

Study Completion Date

August 27, 2025

Conditions
Squamous Cell Carcinoma of Head and Neck
Interventions
DRUG

Atezolizumab

Atezolizumab at a fixed dose of 1200 mg will be administered by intravenous (IV) infusion Q3W on Day 1 of each 21-day cycle.

DRUG

Tiragolumab

Tiragolumab at a fixed dose of 600 mg will be administered by IV infusion Q3W on Day 1 of each 21-day cycle.

DRUG

Placebo

Placebo will be administered by IV infusion Q3W on Day 1 of each 21-day cycle.

Trial Locations (47)

404

China Medical University Hospital, Taichung

1023

Auckland City Hospital, Cancer and Blood Research, Auckland

6000

Bacs-Kiskun Megyei Korhaz, SZTE AOK Oktato Korhaza, Onkoradiologiai Kozpont, Kecskemét

7623

Pécsi Tudományegyetem, Pécs

9024

Gy?r-Moson-Sopron Vármegyei Petz Aladár Egyetemi Oktató Kórház, Gy?r

10048

National Taiwan University Hospital, Zhongzheng Dist.

10400

Ramathibodi Hospital, Bangkok

12462

Attiko Hospital University of Athens, Athens

14076

Centre Francois Baclesse, Caen

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

21287

Johns Hopkins Hospital, Baltimore

25100

Asst Degli Spedali Civili Di Brescia, Brescia

32308

SCRI Florida Cancer Specialists PAN, Tallahassee

33075

CHU Bordeaux, Bordeaux

34298

Institut régional du Cancer Montpellier, Montpellier

37203

Tennessee Oncology - Nashville, Nashville

46026

Hospital Universitari i Politecnic La Fe, Valencia

50134

Azienda Ospedaliero-Universitaria Careggi, Florence

54519

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

63108

Washington University School of Medicine, St Louis

69373

Centre Leon Berard, Lyon

75231

Institut Curie, Paris

77030

MD Anderson Cancer Center, Houston

90095

UCLA, Los Angeles

90110

Songklanagarind Hospital, Songkhla

92093

Moores Cancer Center at UC San Diego Health, La Jolla

112201

Taipei Veterans General Hospital, Taipei

656 53

Masarykuv onkologicky ustav, Brno

500 05

Fakultni nemocnice Hradec Kralove, Hradec Králové

150 06

Fakultni nemocnice v Motole, Prague

115 22

Anticancer Hospital Ag Savas, Athens

711 10

Periph. University General Hospital of Heraklion Crete, Heraklion

546 45

Euromedical General Clinic of Thessaloniki, Thessaloniki

43-300

Beskidzkie Centrum Onkologii- Szpital Miejski, Bielsko-Biala

80-214

Uniwersyteckie Centrum Kliniczne, Gda?sk

90-242

Centrum Terapii Wspolczesnej J.M.Jasnorzewska Spolka Komandytowo-Akcyjna, Lodz

20-090

Centrum Onkologii Ziemi Lubelskiej Im. ?W. Jana Z Dukli, Lublin

Unknown

Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08916

Hospital Universitari Germans Trias i Pujol, Badalona

08908

Institut Catala d Oncologia Hospital Duran i Reynals, Barcelona

CF14 2TL

Velindre Cancer Centre, Cardiff

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

SE1 9RT

Guys and St Thomas NHS Foundation Trust, Guys Hospital, London

SM2 5PT

Royal Marsden NHS Foundation Trust, Sutton

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT04665843 - A Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Participants With Recurrent/Metastatic PD-L1 Positive Squamous Cell Carcinoma of the Head and Neck | Biotech Hunter | Biotech Hunter