50
Participants
Start Date
February 24, 2021
Primary Completion Date
May 23, 2022
Study Completion Date
October 11, 2022
Rituximab IV
Rituximab will be administered intravenously through Cycle 1-8 at a standard dose of 375 mg/m\^2 (milligram per square meter).
Rituximab SC
Rituximab will be administered subcutaneously through Cycle 2-8 at a dose of 1400 milligram (mg).
Rituximab IV
Rituximab will be administered intravenously in Cycle 1 at a standard dose of 375 mg/m\^2.
Cyclophosphamide
Cyclophosphamide will be administered IV at a dose of 750 mg/m\^2
Doxorubicin
Doxorubicin will be administered IV at a dose of 50 mg/m\^2
Vincristine
Vincristine will be administered IV at a dose of 1.4 mg/m\^2
Prednisone
Prednisone will be administered orally at a dose of 100 mg/day
Paracetamol
All participants are required to receive 1000 mg oral paracetamol as premedication prior to starting each infusion of rituximab
Diphenhydramine hydrochloride or alternative antihistamine
All participants are required to receive 50-100 mg oral diphenhydramine hydrochloride or alternative antihistamine as premedication prior to starting each infusion of rituximab
Peking University Third Hospital, Beijing
The First Hospital of Jilin University, Changchun
Harbin Medical University Cancer Hospital, Harbin
Tianjin Medical University Cancer Institute & Hospital, Tianjing
The 1st Affiliated Hospital of Nanchang Unversity, Nanchang
Fujian Provincial Cancer Hospital, Fuzhou
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan
The First Affiliated Hospital of Xian Jiao Tong University, Xi'an
Hoffmann-La Roche
INDUSTRY