761
Participants
Start Date
May 3, 2021
Primary Completion Date
June 15, 2025
Study Completion Date
September 13, 2026
Atezolizumab
ctDNA positive participants will receive 1680 mg intravenously every 4 weeks (Q4W) on Day 1 of each 28-day cycle.
Placebo
ctDNA positive participants will receive placebo intravenously Q4W on Day 1 of each 28-day cycle
Signatera
Signatera will be used to evaluate whether circulating tumor DNA (ctDNA) is detected during serial monitoring of peripheral blood samples for participants enrolled in surveillance. Participants with a ctDNA positive result will be screened for inclusion in the treatment phase. Participants who remain ctDNA negative at 12 months from the date of cystectomy will not be randomized to treatment and will enter follow-up.
Centro Medico Austral, Buenos Aires
Instituto Alexander Fleming, Buenos Aires
AZ KLINA, Brasschaat
AZ Delta (Campus Rumbeke), Roeselare
UZ Gent, Ghent
A.O. Universitaria S. Luigi Gonzaga, Orbassano
National Cancer Center, Goyang-si
Clinica del Country, Bogotá
Hospital Universitario Reina Sofia, Córdoba
AHN Cancer Institute ? Allegheny General Hospital, Pittsburgh
A.O. Universitaria S. Martino Di Genova, Genoa
Hospital de Donostia, Donostia / San Sebastian
Azienda Ospedaliera Santa Maria di Terni, Terni
Irccs Ospedale San Raffaele, Milan
Irccs Istituto Nazionale Dei Tumori (Int), Milan
Istituto Europeo Di Oncologia, Milan
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi, Edirne
Wake Forest Baptist Medical Center, Winston-Salem
Hospital Ramon y Cajal, Madrid
Hospital Clinico San Carlos, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario La Paz, Madrid
Institut Claudius Régaud, Toulouse
Cancer Care Centers of Brevard, Rockledge
Hopital Saint Andre, Bordeaux
Istanbul University Cerrahpasa Faculty of Medicine, Istanbul
Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji, Bakirkoy / Istanbul
Medeniyet University Goztepe Training and Research Hospital., Istanbul
IOV - Istituto Oncologico Veneto - IRCCS, Padua
Medikal Park Izmir Hospital, Kar??yaka
Hospital Universitario Marques de Valdecilla, Santander
AZ.Osp S. Orsola ? Malpighi-Reparto di Oncologia Medica, Bologna
Universitätsklinikum Düsseldorf, Düsseldorf
Hospital Universitario Virgen del Rocio, Seville
Cleveland Clinic, Cleveland
Universitätsklinikum der Ruhr-Universität Bochum, Marien-Hospital Herne, Urologische Klinik, Herne
Instituto Valenciano Oncologia, Valencia
Hospital Clinico Universitario de Valencia, Valencia
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola, Meldola
ME Dnipropetrovsk Regional Clinical Hospital n.a. I.I Mechnykov Dnipropetrovsk Regional Council, Dnipro
ICO Paul Papin, Angers
CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC SI Dnipropetrovsk MA of MOHU Ch of Oncology and MR, Dnipropetrovsk
Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato, Arezzo
Theageneio Hospital, Thessaloniki
Centre D'Oncologie de Gentilly, Nancy
Medikal Park Samsun, Samsun
Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval Department of Urology #4, Kharkiv
Centre Jean Perrin, Clermont-Ferrand
CUAN Hospital, San Pedro Garza García
Centre Léon Bérard, Lyon
Universitätsklinikum Tübingen, Tübingen
Institut Mutualiste Montsouris, Paris
Lviv Regional Clinical Hospital, Lviv
Rocky Mountain Cancer Center - Denver, Littleton
"Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli, Day Hospital Oncologico", Napoli
Istituto Nazionale Tumori Irccs Fondazione G. Pascale, Napoli
Klinikum rechts der Isar der TU München, München
Institut Sainte Catherine, Avignon
Universitätsklinikum Ulm, Ulm
Optum Health Care, Las Vegas
UCLA Department of Medicine, Santa Monica
Hopital Foch, Suresnes
Institut Gustave Roussy, Villejuif
Universitätsklinikum Würzburg, Würzburg
Friendship Hospital, Capital Medical University, Beijing
Liaoning cancer Hospital & Institute, Shenyang
the First Hospital of Jilin University, Changchun
Ivanovo Regional Oncology Dispensary, Ivanovo
National Cancer Centre, Singapore
Murmansk Regional Clinical Hospital named after P.A. Bayandin, Murmansk
St-Petersburg Regional Oncology Dispensary, Kuzmolovo
FSI Russian Centre of Radiology and Surgical Technologies, Saint Petersburg
Zhongshan Hospital Fudan University, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Jiangsu Cancer Hospital, Nanjing
Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University), Nanjing
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing
Oncomedica S.A., Montería
Yantai Yu Huangding Hospital, Yantai
Tianjin Cancer Hospital, Tianjin
Fujian Medical University Union Hospital, Fujian
The First Affiliated Hospital of Fujian Medical University, Fuzhou
Chongqing Cancer Hospital, Chongqing
Hu Nan Provincial Cancer Hospital, Changsha
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou
Privolzhsk Regional Medical Center, Nizhny Novgorod
Rambam Medical Center, Haifa
Tel Aviv Sourasky Medical Ctr, Tel Aviv
CETUS Hospital Dia Oncologia, Belo Horizonte
Oncocentro Serviços Medicos E Hospitalares Ltda, Fortaleza
Cork Uni Hospital, Cork
Dolnoslaskie Centrum Onkologii, Wroc?aw
Hospital Erasto Gaertner, Curitiba
Hospital Moinhos de Vento, Porto Alegre
Hospital Sao Lucas - PUCRS, Porto Alegre
Hospital Nossa Senhora da Conceicao, Porto Alegre
*X*Fundação Pio XII Hospital de Câncer de Barretos, Barretos
Hospital Amaral Carvalho, Jaú
Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Hospital Alemao Oswaldo Cruz, São Paulo
Instituto Cancerología Medellin, Medellín
Fakultni nemocnice Olomouc, Olomouc
Fakultni nemocnice v Motole, Prague
Fakultni Thomayerova nemocnice, Praha 4 - Krc
Centre Antoine Lacassagne, Nice
Krankenhaus Martha-Maria Halle-Dölau, Klinik für Urologie, Halle
Attikon University General Hospital, Ahens
Alexandras General Hospital of Athens, Athens
University Hospital of Larissa, Larissa
University Hospital of Patras Medical Oncology, Pátrai
Queen Mary Hospital, Hong Kong
Adelaide & Meath Hospital, Dublin, Incorporating the National Children's Hospital, Dublin
"Policlinico Universitario Agostino Gemelli", Rome
Nagoya University Hospital, Aichi
Chiba Cancer Center, Chiba
Toho University Sakura Medical Center, Chiba
Shikoku Cancer Center, Ehime
Kyushu University Hospital, Fukuoka
Fukuyama City Hospital, Hiroshima
Hiroshima City Hiroshima Citizens Hospital, Hiroshima
National Hospital Organization Hokkaido Cancer Center, Hokkaido
University of Tsukuba Hospital, Ibaraki
St. Marianna University Hospital, Kanagawa
Yokosuka Kyosai Hospital, Kanagawa
Kyoto University Hospital, Kyoto
Nagano Municipal Hospital, Nagano
Iwate Medical University Hospital, Numakunai
Okayama University Hospital, Okayama
Osaka International Cancer Institute, Osaka
Saitama Medical University International Medical Center, Saitama
Saitama Cancer Center, Saitama
Shizuoka Cancer Center, Shizuoka
Tokushima University Hospital, Tokushima
National Cancer Center Hospital, Tokyo
Keio University Hospital, Tokyo
Toyama University Hospital, Toyama
PRATIA MCM Kraków, Krakow
Szpital Kliniczny im. Heliodora ?wi?cickiego UM w Poznaniu, Późna
Szpital Grochowski im. dr med. Rafa?a Masztaka Sp. z o.o., Warsaw
Samsung Medical Center, Seoul
Seoul National University Hospital, Seoul
Asan Medical Center, Seoul
Corporacio Sanitaria Parc Tauli, Sabadell
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clínic i Provincial, Barcelona
Hospital de la Santa Creu i Sant Pau, Barcelona
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital, Adana
Ankara University Faculty of Medicine Cebeci Hospital, Ankara
Ankara City Hospital, Ankara
Kyiv City Clinical Oncological Center, Kyiv
Addenbrookes Hospital, Cambridge
Western General Hospital, Edinburgh
Barts Hospital, London
University College London NHS Foundation Trust, London
Royal Marsden Hospital - London, London
Charing Cross Hospital, London
Derriford Hospital, Plymouth
Royal Preston Hospital, Preston
Weston Park Hospital, Sheffield
Southampton University Hospitals NHS Trust, Southampton
Royal Marsden Hospital (Sutton), Sutton
Collaborators (1)
Natera, Inc.
INDUSTRY
Hoffmann-La Roche
INDUSTRY