Counteracting Deleterious Metabolic Glucocorticoid Effects With Metformin

PHASE4CompletedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

February 25, 2021

Primary Completion Date

August 18, 2021

Study Completion Date

August 18, 2021

Conditions
Glucocorticoid Effect
Interventions
DRUG

Metformin 500 mg Oral Tablets + Prednisone 20mg Tablets

"During one phase of the study: Metformin 500mg Day 1 1-0-0 Day 2 1-0-0 Day 3 1-0-1 Day 4 1-0-1 Day 5 2-0-1 Day 6 2-0-1 Day 7 4-0-0~In combination with prednisone 20mg: day 1 to day 7 1.5-0-0."

DRUG

Placebo 500 mg Tablets + Prednisone 20mg Tablets

During another phase of the study: identical looking placebo pills starting day 1 500mg 1-0-0, day 2 500mg 1-0-0, day 3 500mg 1-0-1, day 4 500mg 1-0-1, day 5 500mg 2-0-1. day 6 2-0-1, day 7 4-0-0. In combination with prednisone 20mg: day 1 to day 7 1.5-0-0.

Trial Locations (1)

4031

University Hospital Basel, Basel

All Listed Sponsors
lead

Eleonora Seelig

OTHER

NCT04659915 - Counteracting Deleterious Metabolic Glucocorticoid Effects With Metformin | Biotech Hunter | Biotech Hunter