Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation in the ICU

NARecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

February 1, 2023

Primary Completion Date

October 31, 2026

Study Completion Date

October 31, 2026

Conditions
Weaning Failure
Interventions
OTHER

Procedure: Usual Care (UC)

Intermittent spontaneous breathing periods

OTHER

Procedure: UC + HI-IMT

UC + Supervised daily sessions of training including 4 sets of 6-10 full vital capacity breaths against an external load using a tapered flow resistive device (POWERbreathe KH2, HaB International, UK). The maximum tolerable resistance allowing patients to inhale at least 70% of their inspiratory vital capacity will be chosen and progressively increased throughout the training period.

OTHER

Procedure: UC + LI-IMT (sham IMT)

UC + superrvised daily sessions of training including 4 sets of 6-10 breaths at the lowest external imposable load with the tapered flow resistive device (POWERbreathe KH2, HaB International, UK) (i.e. 3 cmH2O).

Trial Locations (1)

3000

RECRUITING

University Hospital Leuven, Leuven

All Listed Sponsors
lead

KU Leuven

OTHER