A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

257

Participants

Timeline

Start Date

January 15, 2021

Primary Completion Date

December 14, 2025

Study Completion Date

March 23, 2026

Conditions
Melanoma
Interventions
DRUG

Encorafenib

Encorafenib

DRUG

Binimetinib

Binimetinib

DRUG

Pembrolizumab

Pembrolizumab

Trial Locations (132)

1085

Semmelweis Egyetem, Budapest

1122

Orszagos Onkologiai Intezet, Budapest

1200

Cliniques universitaires Saint-Luc, Brussels

1373

Medical Center Nadezhda Clinical EOOD, Sofia

1407

Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD, Sofia

1756

Umhato Ead, Sofia

2193

WCR Office, Johannesburg

Wits Clinical Research, Johannesburg

2196

Sandton Oncology Medical Group (Pty) Ltd, Johannesburg

4004

Complex Oncology Center - Plovdiv EOOD, Plovdiv

4032

Debreceni Egyetem Klinikai Kozpont, Debrecen

4414

Palmerston North Hospital, Palmerston North

5004

Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház, Szolnok

6720

Szent-Gyorgyi Albert Klinikai Kozpont, Szeged

7632

Pécsi Tudományegyetem Klinikai Központ, Pécs

8036

Medizinische Universität Graz, Graz

8058

UniversitätsSpital Zürich, Zürich Flughafen

8500

Clinica Viedma S. A, Viedma

10060

Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia, Candiolo

10117

Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin

11527

"General Hospital of Athens Laiko", Athens

Laiko Hospital, Athens

14004

Hospital Universitario Reina Sofía, Córdoba

15006

CHUAC-Hospital Teresa Herrera, A Coruña

16132

IRCCS Ospedale Policlinico San Martino, Genova

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20141

Istituto Europeo di Oncologia IRCCS, Milan

20246

Universitaetsklinikum Hamburg-Eppendorf, Hamburg

23007

Complejo Hospitalario de Jaen, Jaén

23538

Universitätsklinikum Schleswig-Holstein, Lübeck

24105

Universitaetsklinikum Schleswig-Holstein Campus Kiel, Kiel

25198

Hospital Universitario Arnau de Vilanova, Lleida

28034

Hospital Universitario Ramón y Cajal, Madrid

28222

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda

29011

Hospital Regional Universitario de Malaga - Hospital Civil, Málaga

30120

Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar

30625

Medizinische Hochschule Hannover, Hanover

32429

Johannes Wesling Klinikum Minden, Minden

32804

AdventHealth Orlando Infusion Center, Orlando

AdventHealth Orlando, Investigational Drug Services, Orlando

AdventHealth Orlando, Orlando

33100

Azienda Sanitaria Universitaria Friuli Centrale, Udine

33520

Tampereen yliopistollinen sairaala, Tampere

34098

Istanbul University Cerrahpasa Medical Faculty Hospital, Istanbul

34722

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul

35128

Istituto Oncologico Veneto IOV - IRCCS, Padua

37178

Preparaciones Oncológicas S.C., León

37203

Sarah Cannon Research Institute, Nashville

Tennessee Oncology, PLLC, Nashville

37920

University of Tennessee Medical Center, Knoxville

38700

CHU Grenoble Alpes, La Tronche

39008

Hospital Universitario Marqués de Valdecilla, Santander

41009

Hospital Universitario Virgen Macarena, Seville

41013

Hospital Universitario Virgen del Rocio, Seville

45069

University of Cincinnati Medical Center, West Chester

45147

Universitätsklinikum Essen (AöR), Essen

45219

University of Cincinnati Medical Center, Cincinnati

46009

Fundacion Instituto Valenciano de Oncologia, Valencia

48149

University Hospital Muenster, Münster

48157

Fachklinik Hornheide, Münster

50009

Hospital Universitario Miguel Servet, Zaragoza

53100

"A.O.U.S. Policlinico Le Scotte", Siena

53127

Universitätsklinikum Bonn, Bonn

55131

Universitätsmedizin Johannes Gutenberg Universität Mainz, Mainz

61103

Derzhavna ustanova Instytut zahalnoi ta nevidkladnoi khirurhii im.V.T.Zaitseva Natsionalnoi akademii, M. Kharkiv

61166

"CNI KRC Regional Cardiology Centre", Kharkiv

64710

I Can Oncology Center S.A. de C.V., Monterrey

66205

The University of Kansas Clinical Research Center, Fairway

The University of Kansas Cancer Center, Investigational Drug Services, Westwood

The University of Kansas Cancer Center, Westwood

66210

The University of Kansas Cancer Center - Overland Park, Overland Park

69120

Universitätsklinikum Heidelberg, Heidelberg

69310

Hôpital Lyon Sud, Pierre-Bénite

70124

Istituto Tumori Giovanni Paolo II, Bari

72076

Universitaetsklinikum Tuebingen, Tübingen

72160

El Cielo Medical Center RSB, S.C, Puebla City

79031

"Communal Noncommercial Enterprise of Lviv Regional Council Lviv Oncological Regional Therapeutical", Lviv

80054

CHU d'Amiens - Hôpital Nord, Amiens

80131

"Istituto Nazionale Tumori IRCCS Fondazione G. Pascale", Napoli

80337

Klinik und Poliklinik für Dermatologie und Allergologie, München

86000

CHU de Poitiers, Poitiers

90419

Klinikum Nürnberg Nord, Nuremberg

93053

Universitätsklinikum Regensburg, Regensburg

95801

Nemocnica na okraji mesta, n.o., Partizánske

99089

HELIOS Klinikum Erfurt, Erfurt

196603

"Private Medical Institution Euromedservice", Pushkin

197022

Eurocityclinic LLC, Saint Petersburg

644046

"BIH of Omsk Region Clinical Oncological Dispensary", Omsk

8410101

Soroka University Medical Center, Beersheba

9112001

Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem, Jerusalem

02114

Massachusetts General Hospital, Boston

Ophthalmic Consultants of Boston Inc (OCB), Boston

C1426ANZ

Instituto Alexander Fleming, CABA

80520-174

Instituto de Oncologia do Paraná - IOP Matriz Mateus Leme, Curitiba

82305-100

Instituto de Oncologia do Paraná - IOP Oncoville, Curitiba

20220-410

Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro

99010-260

Hospital de Clínicas de Passo Fundo, Passo Fundo

90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

14784-400

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos

01308-050

Hospital Sírio-Libanês - Unidade Bela Vista, São Paulo

G7H 5H6

CIUSSS du Saguenay-Lac-Saint-Jean, Chicoutimi

779 00

Olomouc University Hospital, Olomouc

708 52

Fakultni nemocnice Ostrava, Ostrava-Poruba

180 81

Fakultni nemocnice Bulovka, Praha 8-Liben

00029

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki

01307

Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden, Dresden

04103

Universitätsklinikum Leipzig, Leipzig

07548

SRH Wald-Klinikum Gera, Gera

06120

Universitaetsklinikum Halle - Universitaetsklinik und Poliklinik fuer Dermatologie und Venerologie, Halle

00167

Istituto Dermopatico dell'Immacolata (IDI-IRCCS), Roma

06132

AO di Perugia - Ospedale S. Maria della Misericordia, S.C Oncologia Medica, Perugia

00144

Istituto Nazionale Tumori Regina Elena, Roma

03810

ONCARE Viaducto Nápoles, Benito Juárez

01120

BRCR Global Mexico - CDMX, Mexico City

0379

Oslo universitetssykehus, Radiumhospitalet, Oslo

30-348

Jagiellońskie Centrum Innowacji Sp. z o .o., Krakow

60-780

Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu, Poznan

02-781

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw

Unknown

Ars Medika Center, LLC, Kaliningrad

812 50

Onkologicky ustav sv. Alzbety, s.r.o., Bratislava

833 10

Narodny onkologicky ustav, Bratislava

04191

Vychodoslovensky onkologicky ustav, a.s., Košice

058 01

POKO Poprad, s.r.o., Poprad

0081

Drs Alberts, Bouwer and Jordaan Inc., Pretoria

08916

ICO-Badalona Hospital Germans Trias i Pujol, Badalona

08035

Hospital Universitari Vall D'Hebron, Servicio de Oncología Médica, Barcelona

08036

Hospital Clinic Barcelona, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

06520

Memorial Ankara Hastanesi, Ankara

03022

National Cancer Institute, Kyiv

EC1A 7BE

St. Bartholomew's Hospital, Barts Health NHS Trust, London

SA2 8QA

The South West Wales Cancer Institute, Swansea Bay University Health Board, Swansea

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Pfizer

INDUSTRY

NCT04657991 - A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma | Biotech Hunter | Biotech Hunter