1,566
Participants
Start Date
June 1, 2019
Primary Completion Date
May 31, 2024
Study Completion Date
May 31, 2024
YEARS algorithm
Patients randomized to the YEARS algorithm will be evaluated according to the YEARS algorithm consisting of three items of the original Wells rule (clinical signs of DVT, haemoptysis and 'PE most likely diagnosis') and a D-dimer test. In patients without any of the three items and a D-dimer level \<1.0 μg/mL (\<1000ng/mL), and in patients with ≥1 items and a D-dimer level \<0.5 μg/mL (\<500 ng/mL) a PE is excluded without CTPA. In the other patients a standard contrast enhanced CTPA will be performed according to local practice. PE is defined as at least one filling defect in the pulmonary artery tree on CTPA.
CTPA
Patients randomized to the CTPA management group will undergo a contrast enhanced CTPA to rule out PE according to standard local practice.
RECRUITING
CHU Brest, Brest
RECRUITING
CHU Saint-Etienne, Saint-Etienne
NOT_YET_RECRUITING
CHU Clermont-Ferrand, Clermont-Ferrand
NOT_YET_RECRUITING
HEGP, Paris
NOT_YET_RECRUITING
Hôpital Louis Mourier - APHP, Colombes
RECRUITING
Antwerpen University Hospital (UZA), Antwerp
NOT_YET_RECRUITING
Cliniques Universitaires Saint-Luc (CUSL), Brussels
NOT_YET_RECRUITING
Centre Hospitalier Universitaire de Liège (CHU Liège), Liège
RECRUITING
"Policlinico di Milano Ospedale Maggiore , Fondazione IRCCS Ca' Granda"
RECRUITING
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma
ACTIVE_NOT_RECRUITING
Jeroen Bosch Ziekenhuis, 's-Hertogenbosch
RECRUITING
Flevoziekenhuis, Almere Stad
RECRUITING
Amsterdam UMC, Amsterdam
NOT_YET_RECRUITING
Rijnstate Ziekenhuis, Arnhem
RECRUITING
Amphia Ziekenhuis, Breda
RECRUITING
Reinier de Graaf Gasthuis, Delft
RECRUITING
Groene Hart Ziekenhuis, Gouda
RECRUITING
Tergooi MC, Hilversum
RECRUITING
Leiden University Medical Center, Leiden
RECRUITING
Radboud UMC, Nijmegen
RECRUITING
Maasstad Ziekenhuis, Rotterdam
RECRUITING
Haaglanden Medisch Centrum, The Hague
RECRUITING
Bernhoven Ziekenhuis, Uden
RECRUITING
Diakonessenhuis, Utrecht
RECRUITING
Hospital Universitario Ramón y Cajal, Madrid
RECRUITING
The Inselspital Bern, Bern
RECRUITING
Hôpitaux Universitaires de Genève (HUG), Geneva
RECRUITING
Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne
Leiden University Medical Center
OTHER
Insel Gruppe AG, University Hospital Bern
OTHER
University Hospital, Antwerp
OTHER
University Hospital, Brest
OTHER