Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

101

Participants

Timeline

Start Date

February 9, 2021

Primary Completion Date

September 30, 2024

Study Completion Date

December 31, 2025

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Decitabine and Cedazuridine (ASTX727)

Route of administration: oral in the form of a tablet

DRUG

Venetoclax

Route of administration: oral in the form of a tablet

Trial Locations (34)

10065

Weill Cornell Medical College, New York

13210

The Research Foundation of the State University of New York (SUNY), Syracuse

14263

Roswell Park Comprehensive Cancer Center, Buffalo

14627

University of Rochester, Rochester

15232

UPMC Hillman Cancer Center, Pittsburgh

17033

Penn State Milton S. Hershey Medical Center, Hershey

27834

East Carolina University, Greenville

28007

Universitario Gregorio Marañon, Madrid

31008

Clinica Universidad de Navarra, Pamplona, Pamplona

32207

Baptist MD Anderson Cancer Center, Jacksonville

33011

Hospital Universitario Central de Asturias, Oviedo

33322

Boca Raton Clinical Research, Plantation

37007

Hospital Universitario de Salamanca, Salamanca

43210

The Ohio State University, Columbus

46026

Hospital Universitari i Politecnic La Fe, Valencia

46202

Indiana University Simon Cancer Center, Indianapolis

60637

The University of Chicago Medical Center, Chicago

64132

Health Midwest Ventures Group, Inc., Kansas City

76508

Baylor Scott & White Research Institute, Temple

77030

MD Anderson Cancer Center, Houston

90033

USC Norris Comprehensive Cancer Center, Los Angeles

94306

Stanford University, Palo Alto

98109

Seattle Cancer Care Alliance, Seattle

06510

Yale University, New Haven

02111

Tufts Medical Center, Boston

02114

Massachusetts General Hospital, Boston

01655

University of Massachusetts, Memorial Medical Center, Worcester

07601

Hackensack University of Medical Center, Hackensack

37232-6307

Vanderbilt University Medical Center, Nashville

T2N 4N1

University of Calgary - Health Sciences Centre, Calgary

T6G 2R3

University of Alberta, Edmonton

K1H 8L6

The Ottawa Hospital, General Campus, Ottawa

H3T 1E2

Jewish General Hospital, Montreal

08908

Institut Catala d'Oncologia-Hospital Duran i Reynals, L'Hospitalet de Llobregat

All Listed Sponsors
lead

Taiho Oncology, Inc.

INDUSTRY