Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

605

Participants

Timeline

Start Date

December 21, 2020

Primary Completion Date

May 10, 2024

Study Completion Date

January 31, 2026

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

DS-1062a

DS-1062a will be administered as an intravenous (IV) infusion on Day 1 of each 3-week cycle

DRUG

Docetaxel

Docetaxel will be administered as an IV infusion on Day 1 of each 3-week cycle.

Trial Locations (209)

333

LinKou Chang Gung Memorial Hospital, Taoyuan District

1145

Uzsoki Utcai Korhaz, Budapest

2145

Crown Princess Mary Cancer Centre Westmead Hospital, Sydney

3010

Inselspital Universitätsspital Bern, Bern

8063

Stadtspital Waid ; Triemli, Site Triemli - clinic for Medical oncology & hematology, Zurich

9007

Kantonsspital St. Gallen, Sankt Gallen

10043

Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano

10117

Charite - Universitaetsmedizin Berlin, Berlin

10461

Montefiore Medical Center, The Bronx

12800

Vseobecna Fakultni Nemocnice VFN, Prague

13125

Evangelische Lungenklinik Berlin, Berlin

13620

Seoul National University Bundang Hospital, Seongnam-si

13915

APHM - Hopital Nord, Marseille

14050

Hospital Medica Sur Tlalpan, Mexico City

16149

ASL 3 Genovese Oncologia Medica Villa Scassi, Genova

16247

St. Vincents Hospital The Catholic University of Korea, Gyeonggi-do

20122

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan

20125

Centrul Medical Sanador, Bucharest

20133

Fondazione IRCCS Istituto Nazionale Tumori, Milan

20141

IRCCS Istituto Europeo di Oncologia, Milan

20230

San Peregrino Cancer Center, Aguascalientes

20817

American Oncology Partners of Maryland, Bethesda

22031

Virginia Cancer Specialist, Fairfax

22903

University of Virginia Health System, Charlottesville

25030

Hopital Jean Minjoz, Besançon

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28222

Hospital Puerte de Hierro de Majadahonda, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

28806

Messino Cancer Centers, Asheville

29010

Hospital Regional Universitario Málaga, Málaga

31059

CHU Toulouse Hopital Larrey, Toulouse

32005

CHUO, Ourense

32308

Florida Cancer Specialists, Tallahassee

32806

Orlando Health, Orlando

33021

Memorial Healthcare System- Memorial Cancer Institute, Hollywood

35000

Hopital Pontchaillou, Rennes

36927

Okayama University Hospital, Okayama

37203

Sarah Cannon Research Institute, Nashville

38043

Centre Hospitalier Universitaire de Grenoble, Grenoble

40138

Azienda Ospedaliero- Universitaria Policlinico S. Orsola-Malpighi, Bologna

40207

Baptist Health Louisville, Louisville

40705

Taichung Veterans General Hospital, Taichung

41007

Hospital Virgen Macarena, Seville

41014

Hospital Universitario de Valme, Seville

41404

Kyungpook National University Chilgok Hospital, Daegu

43002

Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan

44000

University Hospital of Nantes - Thoracic Oncology, Nantes

44106

University Hospitals Cleveland Medical Center, Cleveland

44280

Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara

46014

Hospital General Universitario de Valencia, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

46804

Ft. Wayne Medical Oncology and Hematology, Fort Wayne

48201

Karmanos Cancer Institute, Detroit

50009

Hospital Clinico Universitario Lozano Bleza, Zaragoza

50937

Universitaet zu Koeln - Uniklinik Koeln, Cologne

57105

Avera Cancer Institute, Sioux Falls

58675

Lungenklinik Hemer, Hemer

60488

IKF Krankenhaus Nordwest, Frankfurt am Main

60611

Northwestern University, Chicago

60637

University of Chicago, Chicago

64460

Hospital Universitario Jose Eleuterio Gonzalez, Monterrey

67098

Hopitaux Universitaire de Strasbourg, Strasbourg

69008

Centre Leon Berard, Lyon

69126

Thoraxklinik Heidelberg gGmbH, Heidelberg

70809

Baton Rouge General, Baton Rouge

75248

Institut Curie, Paris

76104

The Center for Cancer and Blood Disorders, Fort Worth

79106

Universitaetsklinikum Freiburg, Freiburg im Breisgau

80350

Hospital Universitario Vall d'Hebron, Barcelona

82131

Asklepios Fachklinik Muenchen-Gauting, Gauting

84106

Utah Cancer Specialists, Salt Lake City

85224

Ironwood Cancer and Research Center, Chandler

86000

CHU de Poitier Pole regional de Cancerologie, Poitiers

87439

Klinikverbund Allgäu, Kempten

89106

OptumCare Cancer Care, Las Vegas

90095

UCLA, Los Angeles

90602

PIH Health, Whittier

91204

The Oncology Institute of Hope and Innovation, Glendale

92093

University of California San Diego, La Jolla

92150

Hopital Foch, Sureesnes

92835

St. Joseph Heritage Healthcare, Anaheim

94805

Gustav Roussy Cancer Campus Grand Paris, Villejuif

95030

Azienda Ospedaliera Universitaria Policlinico G Rodolico San Marco, Catania

98405

Northwest Medical Specialties, Tacoma

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99999

Prince of Wales Hospital / The Chinese University of Hong Kong, Hong Kong

100142

Beijing Cancer Hospital, Beijing

115478

Federal State Budgetary Institution - N.N. Blokhin National Medical Research Center of Oncology, Moscow

121467

University Headache Clinic LLC, Moscow

129515

VitaMed LLC, Moscow

150081

Harbin Medical University Cancer Hospital, Heilongjiang

154007

Jiamusi Cancer Tuberculosis Hospital, Heilongjiang

169610

National Cancer Centre Singapore, Singapore

197758

N.N. Petrov Research Institute of Oncology, Saint Petersburg

200032

Henan Cancer Hospital, Shanghai Sheng

200103

Onco Clinic Consult SA, Craiova

200347

Sf Nectarie Oncology Center, Craiova

200385

Oncolab SRL, Craiova

217562

ICON Cancer Centre Farrer Park Hospital, Singapore

258499

OncoCare Cancer Centre - Gleneagles Medical Centre Location, Singapore

276000

The First Affiliated Hospital of Xi'an Jiaotong University, Shandong

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

300425

SC Oncomed SRL, Timișoara

305524

Kursk Regional Clinical Oncology Dispensary, Kursk

310003

Linyi Cancer Hospital, Hangzhou

310016

Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Zhejiang

310022

The First Affiliated Hospital of Zhejiang University, Hangzou

430079

Hubei Cancer Hospital, Hubei

430291

SC Oncopremium Team SRL, Baia Mare

450008

Fudan University Shanghai Cancer Center, Henan

630099

"LLC MSCH Klinitsist", Novosibirsk

710061

Zhejiang Cancer Hospital, Shanxi

900591

Clinical Emergency Hospital, Constanța

999077

Queen Mary Hospital, Hong Kong

02115

Dana-Farber Cancer Institute, Boston

08050

Meridian Hematology and Oncology, Manahawkin

08873

Astera Cancer Care, Somerset

02908

Roger Williams Medical Center, Providence

01878

CER San Juan, Buenos Aires

B2700CPM

Centro de Investigacion Pergamino S.A., Pergamino

S2000KZE

Instituto de OncologÃÂ-a de Rosario, Rosario

S2000

Gaston Martinengo, Rosario

05042

Flinders Medical Centre, Bedford Park

02148

Blacktown Hosital, Blacktown

03084

Austin Hospital, Heidelberg

02109

Macquarie Hospital, North Ryde

02500

Southern Medical Day Care Centre, Wollongong

07100

Centre Hospitalier Jolimont-Lobbes, Haine-Saint-Paul

B-6800

CHA Centre Hospitalier de l Ardenne, Libramont

04000

CHR site de la Citadelle, Liège

05530

CHU UCL Namur, Yvoir

60430-230

Instituto do Cancer do Ceara - ICC, Fortaleza

90610-000

Hospital Sao Lucas da Pucrs, Porto Alegre

91350-200

Hospital Nossa Senhora da Conceição, Porto Alegre

20231-050

Instituto Nacional de Cancer-INCA, Rio de Janeiro

15090-000

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

T6G 1Z2

Cross Cancer Institute, Edmonton

M5G0A3

University Health Network - Princess Margaret Hospital, Toronto

ON M4N 3M5

Sunnbrook Health Sciences Centre, Toronto

H4A 3J1

MUHC-Glen Site and MUHC Research Institute, Montreal

Unknown

Hunan Cancer Hospital, Changsha

Xiangya Hospital central south university, Changsha

Jiangsu Province Hospital, Nanjing

Shanghai Chest Hospital, Shanghai

West China Hospital, Sichuan University, Sichuan Province

Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi

CHU Louis Pradel, Lyon

Medizinische Klinik V, Standort Gießen

Klinikum Traunstein, Traunstein

Tolna Megyei Balassa Janos Korhaz, Tolna

Institute of Oncology Hadassah Moscow, Moscow

01121

Orszagos Koranyi TBC es Pulmonologiai Intezet, Budapest

02800

Szent Borbala Korhaz, Tatabánya

H-2045

Tudogyogyintezet Torokbalint, Törökbálint

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

RM00144

Instituicao de Fisioterapeutas Ocupacionais, Roma

673-8558

Hyogo Cancer Center, Akashi

951-8566

Niigata Cancer Center Hospital, Chūōku

812-8582

Kyushu University Hospital, Fukuoka

350-1298

Saitama Medical University International Medical Center, Hidaka

573-1191

Kansai Medical University Hospital, Hirakata

920-8641

Kanazawa University Hospital, Kanazawa

277-8577

National Cancer Center Hospital East, Kashiwa

135-8550

The Cancer Institute Hospital of JFCR, Kōtoku

606-8507

Kyoto University Hospital, Kyoto

791-0280

NHO Shikoku Cancer Center, Matsuyama

411-8777

Shizuoka Cancer Center, Nagaizumi-chō

534-0021

Osaka City General Hospital, Osaka

541-8567

Osaka International Cancer Institute, Osaka

589-8511

Kindai University Hospital, Ōsaka-sayama

362-0806

Saitama Cancer Center, Saitama

980-0873

Sendai Kousei Hospital, Sendai

003-0804

NHO Hokkaido Cancer Center, Shiroishi

770-8503

Tokushima University Hospital, Tokushima

104-0045

National Cancer Center Hospital, Tokyo

470-1192

Fujita Health University Hospital, Toyoake

3000 CA

Erasmus MC, Amsterdam

4818 CK

Amphia Ziekenhuis, Breda

3844 DG

Isala Klinieken, Harderwijk

3015 CD

St. Jansdal Ziekenhuis, Rotterdam

15-276

II Klinika Chorob Pluc i Gruzlicy, Bialystok

81-519

Szpitale Pomorskie Sp.zo.o, Gdynia

20-090

Ms Pneumed, Lublin

10-357

SP Zespol Gruzlicy i Chorob Pluc, Olsztyn

60-693

Med Polonia Sp. z o.o., Poznan

82-550

Szpital Specjalistyczny w Prabutach Sp. z o.o., Prabuty

76-200

Oddział Onkologii Wojewódzki Szpital Specjalistyczny Słupsk, Słupsk

01-748

Magodent Sp. z.o.o Szpital Elblaska, Warsaw

02-781

Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw

00927

FDI Clinical Research, San Juan

022328

Institutul Oncologic Profesor Doctor Alexandru Trestioreanu, Bucharest

03181

Kangbuk Samsung Hospital, Seoul

03722

Yonsei University Health System - Severance Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St. Marys Hospital, Seoul

07061

Seoul National University Boramae Medical Center, Seoul

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08036

Hospital Clinic i Provincial de Barcelona, Barcelona

00824

E-Da Hospital, Kaohsiung City

00833

Chang Gung Memorial Hospital CGMH - Kaohsiung Branch, Niaosong

00420

Chung Shan Medical University Hospital, Taichung

00704

National Cheng Kung University Hospital NCKUH, Tainan City

00736

Chi Mei Medical Center CMMC - Liouying Branch, Tainan City

00100

National Taiwan University Hospital NTUH, Taipei

NW1 2BU

University College Hospital, London

M20 4BX

The Christie Hospital, Manchester

TS4 3BW

The James Cook University Hospital, Middlesbrough

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Daiichi Sankyo

INDUSTRY