COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis

PHASE3CompletedINTERVENTIONAL
Enrollment

1,291

Participants

Timeline

Start Date

February 15, 2021

Primary Completion Date

July 24, 2022

Study Completion Date

September 23, 2022

Conditions
Covid19
Interventions
DRUG

Apixaban 2.5 MG

Participants will take Apixaban 2.5 MG twice a day, once in the morning and once in the evening for 30 days. Participants will be contacted (electronic or telephone) 2 days after starting the study medication and will continue up to day 90 after starting study treatment. Followup will occur from the time of discharge through the 30 day study period with contacts at 2 days, 10 days, 20 days and 30 days after discharge. Two additional study contacts will take place 45 days and 90 days after discharge.

DRUG

Placebo

Participants will take placebo twice a day, once in the morning and once in the evening for 30 days. Participants will be contacted (electronic or telephone) 2 days after starting the study medication and will continue up to day 90 after starting study treatment. Followup will occur from the time of discharge through the 30 day study period with contacts at 2 days, 10 days, 20 days and 30 days after discharge. Two additional study contacts will take place 45 days and 90 days after discharge.

Trial Locations (121)

10016

New York University Langone Health, New York

10467

Montefiore Medical Center, The Bronx

10595

Westchester Medical Center, Valhalla

11235

Coney Island Hospital, Brooklyn

11418

Jamaica Hospital Medical Center, Jamaica

11794

Stony Brook University Hospital, Stony Brook

14203

Buffalo General Medical Center, Buffalo

14220

Mercy Hospital Buffalo, Buffalo

15213

University of Pittsburgh, Pittsburgh

15905

Conemaugh Memorial Medical Center, Johnstown

18045

St. Luke's University Health Network, Easton

19140

Temple University Hospital, Philadelphia

19611

Tower Health Medical Group, West Reading

20850

Adventist HealthCare Shady Grove Medical Center, Rockville

21215

Lifebridge (Sinai Hospital of Baltimore), Baltimore

21401

Anne Arundel Medical Center, Annapolis

25304

CAMC Clinical Trials Center, Charleston

26506

West Virginia University Hospital, Morgantown

27157

Wake Forest Baptist Medical Center, Winston-Salem

27514

University of North Carolina at Chapel Hill, Chapel Hill

27610

Wake Med Hospital, Raleigh

27710

Duke Medical Center, Durham

27858

East Carolina University/Vidant Health, Greenville

30308

Emory University, Atlanta

30912

Medical College of Georgia/Augusta University, Augusta

31404

Savannah Health Services, LLC DBA Memorial Health University Medical Center, Savannah

32308

Tallahassee Memorial HealthCare, Tallahassee

32610

University of Florida, Gainesville

33140

Mount Sinai Medical Center, Miami Beach

33612

James A. Haley Veteran's Hospital, Tampa

33756

Baycare Hospital, Clearwater

33881

BayCare Hospital- Winter Haven, Winter Haven

34590

Florida Heart Center, Ft. Pierce

37232

Vanderbilt University Medical Center, Nashville

37403

Erlanger Health System, Chattanooga

39216

University of Mississippi Medical Center, Jackson

40503

Baptist Health Lexington, Lexington

43210

Ohio State University, Columbus

44195

Cleveland Clinic Foundation, Cleveland

44304

Summa Health, Akron

45267

University of Cincinnati, Cincinnati

45429

Kettering Medical Center, Kettering

46202

Indiana University Health Methodist Hospital, Indianapolis

46360

Franciscan Health Michigan City, Michigan City

46804

Lutheran Medical Group, Fort Wayne

47374

Reid Physician Associates, Richmond

47403

Indiana University Health Bloomington Hospital, Bloomington

48043

McLaren Macomb, Mount Clemens

48202

Henry Ford Hospital, Detroit

48670

MidMichigan Medical Center, Midland

48708

Bay Regional Medical Center d/b/a/ McLaren Bay Region, Bay City

49008

Western Michigan University, Kalamazoo

53226

Blood Center of Wisconsin, Milwaukee

55417

Minneapolis VA Health Care System, Minneapolis

57701

Monument Health Clinical Research, Rapid City

59701

Mercury Street Medical Group, Butte

60153

Loyola University Medical Center, Maywood

60607

University of Illinois at Chicago, Chicago

60612

Cook County Health, Chicago

Rush University Medical Center, Chicago

60637

The University of Chicago Medicine, Chicago

60805

OSF Little Company of Mary, Evergreen Park

63110

Barnes-Jewish Hospital, St Louis

St Louis University, St Louis

64108

Truman Medical Center, Kansas City

68510

CHI St Elizabeth Hospital, Lincoln

70112

University Medical Center New Orleans, New Orleans

70121

Ochsner Clinic Foundation-Baton Rouge, New Orleans

Ochsner Clinic Foundation, New Orleans

71103

Willis-Knighton Physician Network/Tri-State Medical Clinic, Shreveport

72205

Central Arkansas Veterans Health Care System, Little Rock

University of Arkansas for Medical Sciences, Little Rock

74104

Ascension St. John Bartlesville, Tulsa

Ascension St. John Tulsa, Tulsa

75024

Texas Health Frisco, Plano

75390

University of Texas Southwestern Medical Center, Dallas

75701

CHRISTUS Trinity Clinic Pulmonary Medicine, Tyler

75708

The University of Texas Health Science Center at Tyler, Tyler

UT Health East Texas (Tyler), Tyler

76104

Texas Health Harris Methodist, Fort Worth

76508

Baylor Scott and White-Temple, Temple

77030

University of Texas- Houston, LBJ Hospital, Houston

UT Houston MHH-SW, Houston

UTHouston, Houston

77380

The Woodlands Center For Respiratory & Sleep Research, The Woodlands

77702

Christus St. Elizabeth Hospital, Beaumont

77845

Baylor Scott and White Medical Center- College Station, College Station

78596

UT Rio Grande Valley, Weslaco

78665

Baylor Scott and White-Round Rock, Round Rock

80023

St. Anthony North Health Campus, Westminster

80210

Centura Health Porter Adventist Hospital, Denver

80228

Saint Anthony Hospital, Lakewood

83404

Snake River Research, PLLC, Idaho Falls

85008

Valleywise Health Medical Center, Phoenix

85013

Dignity Health-St Josephs, Phoenix

87505

Christus St. Vincent Regional Medical Center, Santa Fe

89502

Renown Health, Reno

90502

Torrance Medical Center, Torrance

91360

Mazur and Statner MD PC, Thousand Oaks

91733

New Ananda Medical and Urgent Care, Inc., South El Monte

94110

UCSF at Zuckerberg San Francisco General Hospital, San Francisco

94304

Stanford University School of Medicine, Palo Alto

96813

Queens Medical Center, Honolulu

96827

Hawaii Pacific Health, Honolulu

97239

Oregon Health and Science University, Portland

98055

UW Medicine Valley Medical Center, Renton

98101

Virginia Mason Medical Center, Seattle

98372

MultiCare Institute for Research & Innovation, Puyallup

111220

NYU Langone Hospital-Brooklyn, Brooklyn

04102

Maine Medical Center/Maine Medical Partners Adult Hospital Medicine, Portland

04856

Pen Bay Medical Center, Rockport

02118

Boston University, Boston

01805

Lahey Hospital and Medical Center, Burlington

01199

Baystate Medical center, Springfield

03756

Dartmouth Hichcock Medical Center, Lebanon

08401

AtlantiCare Regional Medical Center, Atlantic City

07753

Hope Tower at Jersey Shore University Medical Center, Neptune City

07112

Newark Beth Israel Medical Center, Newark

08638

Capital Health System, Inc., Trenton

02903

Rhode Island Hospital, Providence

02906

The Miriam Hospital, Providence

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Thomas L. Ortel

OTHER

NCT04650087 - COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis | Biotech Hunter | Biotech Hunter