Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

June 8, 2021

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2028

Conditions
Anatomic Stage IV Breast Cancer AJCC v8Invasive Breast CarcinomaMetastatic HER2 Negative Breast CarcinomaMetastatic Malignant Neoplasm in the BrainPrognostic Stage IV Breast Cancer AJCC v8
Interventions
BIOLOGICAL

Sacituzumab Govitecan

Given IV

Trial Locations (296)

11042

Northwell Health/Center for Advanced Medicine, Lake Success

11795

Good Samaritan Hospital Medical Center, West Islip

15219

UPMC-Mercy Hospital, Pittsburgh

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17011

UPMC Camp Hill, Camp Hill

17109

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17408

UPMC Memorial, York

17701

UPMC Susquehanna, Williamsport

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29303

Spartanburg Medical Center, Spartanburg

29341

Gibbs Cancer Center-Gaffney, Gaffney

29379

MGC Hematology Oncology-Union, Union

29651

Gibbs Cancer Center-Pelham, Greer

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

37067

Vanderbilt-Ingram Cancer Center Cool Springs, Franklin

37204

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

38017

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38655

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford

38671

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

38901

Baptist Cancer Center-Grenada, Grenada

39705

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus

40004

Flaget Memorial Hospital, Bardstown

40165

Jewish Hospital Medical Center South, Shepherdsville

40202

Jewish Hospital, Louisville

40215

Saints Mary and Elizabeth Hospital, Louisville

40245

UofL Health Medical Center Northeast, Louisville

40504

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

43623

Mercy Health - Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

South Pointe Hospital, Warrensville Heights

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44195

Cleveland Clinic Foundation, Cleveland

44870

North Coast Cancer Care, Sandusky

44906

Cleveland Clinic Cancer Center Mansfield, Mansfield

45005

Dayton Physicians LLC-Atrium, Franklin

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

45409

Miami Valley Hospital, Dayton

Greater Dayton Cancer Center, Kettering

45415

Dayton Physician LLC-Miami Valley Hospital North, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Dayton Physicians LLC-Miami Valley South, Centerville

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

45840

Armes Family Cancer Center, Findlay

47374

Reid Health, Richmond

48075

Ascension Providence Hospitals - Southfield, Southfield

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48162

Toledo Clinic Cancer Centers-Monroe, Monroe

48374

Ascension Providence Hospitals - Novi, Novi

49221

Hickman Cancer Center, Adrian

50010

Mary Greeley Medical Center, Ames

McFarland Clinic PC - Ames, Ames

50036

McFarland Clinic PC-Boone, Boone

50129

McFarland Clinic PC-Jefferson, Jefferson

50158

McFarland Clinic PC-Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50314

Broadlawns Medical Center, Des Moines

Medical Oncology and Hematology Associates-Laurel, Des Moines

Mercy Medical Center - Des Moines, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

Mercy Cancer Center-West Lakes, Clive

50501

McFarland Clinic PC-Trinity Cancer Center, Fort Dodge

Trinity Regional Medical Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

51401

Saint Anthony Regional Hospital, Carroll

51503

Alegent Health Mercy Hospital, Council Bluffs

55905

Mayo Clinic in Rochester, Rochester

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Deaconess Hospital, Bozeman

59802

Saint Patrick Hospital - Community Hospital, Missoula

59804

Community Medical Hospital, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60504

Rush - Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

60611

Northwestern University, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle on Vermilion, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

Saint Anthony's Health, Alton

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63127

Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

Truman Medical Centers, Kansas City

64116

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65109

Capital Region Southwest Campus, Jefferson City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66061

Olathe Health Cancer Center, Olathe

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66606

University of Kansas Health System Saint Francis Campus, Topeka

66762

Ascension Via Christi - Pittsburg, Pittsburg

67401

Salina Regional Health Center, Salina

67530

Central Care Cancer Center - Great Bend, Great Bend

67601

HaysMed University of Kansas Health System, Hays

67846

Central Care Cancer Center - Garden City, Garden City

68046

Midlands Community Hospital, Papillion

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68803

CHI Health Saint Francis, Grand Island

68847

CHI Health Good Samaritan, Kearney

71913

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs

72903

Mercy Hospital Fort Smith, Fort Smith

73120

Mercy Hospital Oklahoma City, Oklahoma City

77030

M D Anderson Cancer Center, Houston

77802

Saint Joseph Regional Cancer Center, Bryan

78229

University of Texas Health Science Center at San Antonio, San Antonio

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

The Medical Center of Aurora, Aurora

80112

Rocky Mountain Cancer Centers - Centennial, Centennial

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Rocky Mountain Cancer Centers - Swedish, Englewood

Swedish Medical Center, Englewood

The Melanoma and Skin Cancer Institute, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80122

Littleton Adventist Hospital, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

Sky Ridge Medical Center, Lone Tree

80138

Parker Adventist Hospital, Parker

80209

The Women's Imaging Center, Denver

80210

Porter Adventist Hospital, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

Rose Medical Center, Denver

Western Surgical Care, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80260

Rocky Mountain Cancer Centers-Thornton, Thornton

80303

Boulder Community Foothills Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80539

McKee Medical Center, Loveland

80631

North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

82001

Cheyenne Regional Medical Center-West, Cheyenne

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83617

Walter Knox Memorial Hospital, Emmett

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Idaho Urologic Institute-Meridian, Meridian

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Alphonsus Medical Center-Nampa, Nampa

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

85004

Cancer Center at Saint Joseph's, Phoenix

85704

University of Arizona Cancer Center-Orange Grove Campus, Tucson

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

87102

University of New Mexico Cancer Center, Albuquerque

90404

Saint John's Cancer Institute, Santa Monica

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92627

UC Irvine Health Cancer Center-Newport, Costa Mesa

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande

93444

Mission Hope Medical Oncology - Santa Maria, Santa Maria

94568

Epic Care-Dublin, Dublin

94597

Epic Care Cyberknife Center, Walnut Creek

94608

Bay Area Breast Surgeons Inc, Emeryville

Epic Care Partners in Cancer Care, Emeryville

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

Bay Area Tumor Institute, Oakland

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

97756

Saint Charles Health System-Redmond, Redmond

97814

Saint Alphonsus Medical Center-Baker City, Baker City

97914

Saint Alphonsus Medical Center-Ontario, Ontario

98003

Saint Francis Hospital, Federal Way

98022

Saint Elizabeth Hospital, Enumclaw

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98166

Highline Medical Center-Main Campus, Burien

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98310

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton

Harrison Medical Center, Bremerton

98368

Jefferson Healthcare, Port Townsend

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

Northwest Medical Specialties PLLC, Tacoma

98499

Saint Clare Hospital, Lakewood

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

99701

Fairbanks Memorial Hospital, Fairbanks

94553-3156

Contra Costa Regional Medical Center, Martinez

50266-7700

Methodist West Hospital, West Des Moines

20889-5600

Walter Reed National Military Medical Center, Bethesda

02215

Dana-Farber Cancer Institute, Boston

03103

Solinsky Center for Cancer Care, Manchester

98122-4307

Swedish Medical Center-First Hill, Seattle

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Gilead Sciences

INDUSTRY

lead

SWOG Cancer Research Network

NETWORK

NCT04647916 - Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases | Biotech Hunter | Biotech Hunter