NCT04640571View on ClinicalTrials.gov

Impact of Metformin and Polysorbate 80 on Drug Absorption and Disposition

PHASE4CompletedINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

April 1, 2021

Primary Completion Date

November 1, 2021

Study Completion Date

November 1, 2021

Conditions
Bile Salt Export Pump (BSEP) TransporterPolysorbate 80
Interventions
DRUG

pravastatin and chenodeoxycholic acid, after metformin and placebo

single oral dose of pravastatin 80 mg and chenodeoxycholic acid 250 mg

DRUG

valacyclovir, chenodeoxycholic acid, and enalaprilat, after polysorbate 80 and placebo

single oral dose of valacyclovir 500 mg, chenodeoxycholic acid 250 mg, and enalaprilat 20 mg

Trial Locations (1)

21201

University of Maryland, Baltimore

All Listed Sponsors
lead

University of Maryland, Baltimore

OTHER

NCT04640571 - Impact of Metformin and Polysorbate 80 on Drug Absorption and Disposition | Biotech Hunter | Biotech Hunter