A Phase Ⅱ Clinical Trial of Recombinant Corona Virus Disease-19 (COVID-19) Vaccine (Sf9 Cells)

PHASE2CompletedINTERVENTIONAL
Enrollment

960

Participants

Timeline

Start Date

November 17, 2020

Primary Completion Date

February 18, 2021

Study Completion Date

November 23, 2021

Conditions
COVID-19
Interventions
BIOLOGICAL

Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) & Two dose regimen

18-59 years group, two doses of low-dose (20µg/0.5ml) Recombinant COVID-19 vaccine (Sf9 cells) at the schedule of day 0, 21.

BIOLOGICAL

Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) & Three dose regimen

18-59 years group, three doses of low-dose (20µg/0.5ml) Recombinant COVID-19 vaccine (Sf9 cells) at the schedule of day 0, 14, 28.

BIOLOGICAL

High-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) & Two dose regimen

18-59 years group, two doses of high-dose (40µg/1.0ml) Recombinant COVID-19 vaccine (Sf9 cells) at the schedule of day 0, 21.

BIOLOGICAL

High-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) & Three dose regimen

18-59 years group, three doses of high-dose (40µg/1.0ml) Recombinant COVID-19 vaccine (Sf9 cells) at the schedule of day 0, 14, 28.

BIOLOGICAL

Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) & Two dose regimen

60-85 years group, two doses of low-dose (20µg/0.5ml) Recombinant COVID-19 vaccine (Sf9 cells) at the schedule of day 0, 21.

BIOLOGICAL

Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) & Three dose regimen

60-85 years group, three doses of low-dose (20µg/0.5ml) Recombinant COVID-19 vaccine (Sf9 cells) at the schedule of day 0, 14, 28.

BIOLOGICAL

High-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) & Two dose regimen

60-85 years group, two doses of high-dose (40µg/1.0ml) Recombinant COVID-19 vaccine (Sf9 cells) at the schedule of day 0, 21.

BIOLOGICAL

High-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) & Three dose regimen

60-85 years group, three doses of high-dose (40µg/1.0ml) Recombinant COVID-19 vaccine (Sf9 cells) at the schedule of day 0, 14, 28.

BIOLOGICAL

Low-dose placebo (18-59 years) & Two dose regimen

18-59 years group, two doses of placebo(0.5ml) at the schedule of day 0, 21.

BIOLOGICAL

Low-dose placebo (18-59 years) & Three dose regimen

18-59 years group, three doses of placebo(0.5ml) at the schedule of day 0, 14, 28.

BIOLOGICAL

High-dose placebo (18-59 years) & Two dose regimen

18-59 years group, two doses of placebo(1.0ml) at the schedule of day 0, 21.

BIOLOGICAL

High-dose placebo (18-59 years) & Three dose regimen

18-59 years group, three doses of placebo(1.0ml) at the schedule of day 0, 14, 28.

BIOLOGICAL

Low-dose placebo (60-85 years) & Two dose regimen

60-85 years group, two doses of placebo(0.5ml) at the schedule of day 0, 21.

BIOLOGICAL

Low-dose placebo (60-85 years) & Three dose regimen

60-85 years group, three doses of placebo(0.5ml) at the schedule of day 0, 14, 28.

BIOLOGICAL

High-dose placebo (60-85 years) & Two dose regimen

60-85 years group, two doses of placebo(1.0ml) at the schedule of day 0, 21.

BIOLOGICAL

High-dose placebo (60-85 years) & Three dose regimen

60-85 years group, three doses of placebo(1.0ml) at the schedule of day 0, 14, 28.

Trial Locations (1)

210009

Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing

All Listed Sponsors
collaborator

West China Hospital

OTHER

lead

Jiangsu Province Centers for Disease Control and Prevention

NETWORK

NCT04640402 - A Phase Ⅱ Clinical Trial of Recombinant Corona Virus Disease-19 (COVID-19) Vaccine (Sf9 Cells) | Biotech Hunter | Biotech Hunter