Trying to Find the Correct Length of Treatment with Immune Checkpoint Therapy

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

3

Participants

Timeline

Start Date

May 27, 2022

Primary Completion Date

June 1, 2024

Study Completion Date

September 30, 2030

Conditions
Locally Advanced Bladder Urothelial CarcinomaLocally Advanced Renal Pelvis Urothelial CarcinomaLocally Advanced Ureter Urothelial CarcinomaLocally Advanced Urethral Urothelial CarcinomaLocally Advanced Urothelial CarcinomaMetastatic Bladder Urothelial CarcinomaMetastatic Renal Pelvis Urothelial CarcinomaMetastatic Ureter Urothelial CarcinomaMetastatic Urethral Urothelial CarcinomaMetastatic Urothelial Carcinoma
Interventions
DRUG

Pembrolizumab

Given IV

DRUG

Nivolumab

Given IV

DRUG

Atezolizumab

Given IV

DRUG

Durvalumab

Given IV

DRUG

Avelumab

Given IV

Trial Locations (377)

11042

Northwell Health/Center for Advanced Medicine, Lake Success

11366

Queens Medical Associates PC, Fresh Meadows

11794

Stony Brook University Medical Center, Stony Brook

13126

Upstate Cancer Center at Oswego, Oswego

13210

State University of New York Upstate Medical University, Syracuse

13421

Upstate Cancer Center at Oneida, Oneida

14263

Roswell Park Cancer Institute, Buffalo

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

Lehigh Valley Hospital-Hazleton, Hazleton

18301

Pocono Medical Center, East Stroudsburg

27157

Wake Forest University Health Sciences, Winston-Salem

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

33308

Holy Cross Hospital, Fort Lauderdale

38138

The West Clinic - Wolf River, Germantown

39216

University of Mississippi Medical Center, Jackson

40004

Flaget Memorial Hospital, Bardstown

40165

Jewish Hospital Medical Center South, Shepherdsville

40202

Jewish Hospital, Louisville

40207

Baptist Health Louisville, Louisville

40215

Saints Mary and Elizabeth Hospital, Louisville

40245

UofL Health Medical Center Northeast, Louisville

40475

Baptist Health Richmond, Richmond

40503

Baptist Health Lexington, Lexington

40504

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Baptist Health Corbin, Corbin

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

42003

Baptist Health Paducah, Paducah

42431

Baptist Health Madisonville/Merle Mahr Cancer Center, Madisonville

42701

Baptist Health Hardin, Elizabethtown

43623

Mercy Health - Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

47150

Baptist Health Floyd, New Albany

48038

Henry Ford Hematology Oncology - Hayes, Clinton Township

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48044

Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb

Michigan Breast Specialists-Macomb Township, Macomb

48054

Great Lakes Cancer Management Specialists-Doctors Park, East China

48088

Advanced Breast Care Center PLLC, Warren

48093

Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren

Macomb Hematology Oncology PC, Warren

Michigan Breast Specialists-Warren, Warren

Saint John Macomb-Oakland Hospital, Warren

48106

Saint Joseph Mercy Hospital, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48114

Saint Joseph Mercy Brighton, Brighton

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48118

Saint Joseph Mercy Chelsea, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48126

Henry Ford Medical Center-Fairlane, Dearborn

48154

Hope Cancer Clinic, Livonia

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48162

Toledo Clinic Cancer Centers-Monroe, Monroe

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48188

Saint Joseph Mercy Canton, Canton

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

48192

Henry Ford Wyandotte Hospital, Wyandotte

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48202

Henry Ford Hospital, Detroit

48236

Ascension Saint John Hospital, Detroit

Academic Hematology Oncology Specialists, Grosse Pointe Woods

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods

Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods

48312

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights

48315

Henry Ford Macomb Health Center - Shelby Township, Shelby

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48341

21st Century Oncology-Pontiac, Pontiac

Hope Cancer Center, Pontiac

Newland Medical Associates-Pontiac, Pontiac

Saint Joseph Mercy Oakland, Pontiac

48346

Hematology Oncology Consultants-Clarkston, Clarkston

Newland Medical Associates-Clarkston, Clarkston

48377

Henry Ford Medical Center-Columbus, Novi

48453

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette

48503

Genesee Cancer and Blood Disease Treatment Center, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48723

Caro Cancer Center, Caro

48764

Ascension Saint Joseph Hospital, Tawas City

48912

Sparrow Hospital, Lansing

49201

Allegiance Health, Jackson

49221

Hickman Cancer Center, Adrian

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50314

Broadlawns Medical Center, Des Moines

Mercy Medical Center - Des Moines, Des Moines

Mission Cancer and Blood - Laurel, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

Mercy Cancer Center-West Lakes, Clive

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

Trinity Regional Medical Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

51401

Saint Anthony Regional Hospital, Carroll

51503

Alegent Health Mercy Hospital, Council Bluffs

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

ProHealth D N Greenwald Center, Mukwonago

53188

ProHealth Waukesha Memorial Hospital, Waukesha

UW Cancer Center at ProHealth Care, Waukesha

54017

Cancer Center of Western Wisconsin, New Richmond

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Clinic-Minocqua Center, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55008

Cambridge Medical Center, Cambridge

55082

Lakeview Hospital, Stillwater

55092

Fairview Lakes Medical Center, Wyoming

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

Minnesota Oncology - Burnsville, Burnsville

55362

Monticello Cancer Center, Monticello

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55371

Fairview Northland Medical Center, Princeton

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55805

Saint Luke's Hospital of Duluth, Duluth

56073

New Ulm Medical Center, New Ulm

56187

Sanford Cancer Center Worthington, Worthington

56201

Rice Memorial Hospital, Willmar

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56601

Sanford Joe Lueken Cancer Center, Bemidji

56701

Sanford Thief River Falls Medical Center, Thief River Falls

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58103

Sanford South University Medical Center, Fargo

Southpointe-Sanford Medical Center Fargo, Fargo

58104

Sanford Medical Center Fargo, Fargo

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59802

Saint Patrick Hospital - Community Hospital, Missoula

60504

Rush - Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

60612

Rush University Medical Center, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

Saint Anthony's Health, Alton

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63110

Washington University School of Medicine, St Louis

63127

Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65109

Capital Region Southwest Campus, Jefferson City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

68046

Midlands Community Hospital, Papillion

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68803

CHI Health Saint Francis, Grand Island

68847

CHI Health Good Samaritan, Kearney

70006

East Jefferson General Hospital, Metairie

LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie

70112

Louisiana State University Health Science Center, New Orleans

71913

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs

72205

University of Arkansas for Medical Sciences, Little Rock

72903

Mercy Hospital Fort Smith, Fort Smith

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

77802

Saint Joseph Regional Cancer Center, Bryan

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

The Medical Center of Aurora, Aurora

80112

Rocky Mountain Cancer Centers - Centennial, Centennial

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Rocky Mountain Cancer Centers - Swedish, Englewood

Swedish Medical Center, Englewood

The Melanoma and Skin Cancer Institute, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80122

Littleton Adventist Hospital, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

Sky Ridge Medical Center, Lone Tree

80138

Parker Adventist Hospital, Parker

80209

The Women's Imaging Center, Denver

80210

Porter Adventist Hospital, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

Rose Medical Center, Denver

Western Surgical Care, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80260

Rocky Mountain Cancer Centers-Thornton, Thornton

80303

Boulder Community Foothills Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

80923

Saint Francis Cancer Center, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

82001

Cheyenne Regional Medical Center-West, Cheyenne

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

85004

Cancer Center at Saint Joseph's, Phoenix

87102

University of New Mexico Cancer Center, Albuquerque

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande

93444

Mission Hope Medical Oncology - Santa Maria, Santa Maria

93720

Fresno Cancer Center, Fresno

Kaiser Permanente-Fresno, Fresno

94063

Kaiser Permanente- Marshall Medical Offices, Redwood City

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

94304

Stanford Cancer Institute Palo Alto, Palo Alto

94531

Kaiser Permanente-Deer Valley Medical Center, Antioch

94538

Kaiser Permanente-Fremont, Fremont

94568

Kaiser Permanente Dublin, Dublin

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente Oakland-Broadway, Oakland

Kaiser Permanente-Oakland, Oakland

94801

Kaiser Permanente-Richmond, Richmond

94903

Kaiser San Rafael-Gallinas, San Rafael

94928

Rohnert Park Cancer Center, Rohnert Park

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95210

Kaiser Permanente-Stockton, Stockton

95356

Kaiser Permanente-Modesto, Modesto

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

95661

Kaiser Permanente-Roseville, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95688

Kaiser Permanente Medical Center-Vacaville, Vacaville

95814

Kaiser Permanente Downtown Commons, Sacramento

95823

Kaiser Permanente-South Sacramento, Sacramento

South Sacramento Cancer Center, Sacramento

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

97756

Saint Charles Health System-Redmond, Redmond

98003

Saint Francis Hospital, Federal Way

98022

Saint Elizabeth Hospital, Enumclaw

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98166

Highline Medical Center-Main Campus, Burien

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98310

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton

Harrison Medical Center, Bremerton

98368

Jefferson Healthcare, Port Townsend

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

Northwest Medical Specialties PLLC, Tacoma

98499

Saint Clare Hospital, Lakewood

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

99701

Fairbanks Memorial Hospital, Fairbanks

50266-7700

Methodist West Hospital, West Des Moines

02215

Dana-Farber Cancer Institute, Boston

01757

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford

02467

Dana-Farber Cancer Institute - Chestnut Hill, Newton

02190

Dana-Farber/Brigham and Women's Cancer Center at South Shore, South Weymouth

03053

The Dana-Farber Cancer Institute at Londonderry, Londonderry

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER