14
Participants
Start Date
December 3, 2021
Primary Completion Date
December 31, 2025
Study Completion Date
August 31, 2026
Low Oxalate Diet before Weight Loss
Subjects will be instructed to ingest a controlled diet low in oxalate for a total of 6 days. 2 x 24 hour urines will be collected on days 3 and 4.
Oral load of oxalate and sucralose before Weight Loss
Subjects will ingest 100mg carbon-13 oxalate, and 1 gram of sucralose on day 5 of the 6-day low oxalate diet phase. Following the oral load, blood and urine will be collected every 30 minutes and hourly, respectively
Optifast VLCD Program
Subjects will go on a 10-week Intestive level Optifast VLCD weight loss program
Optifast VLCD Transition Phase
After completion of the 10-week Optifast VLCD Program, subjects will be weaned off the Optifast products for 4 weeks.
Low Oxalate Diet after Weight Loss
Subjects will be instructed to ingest a controlled diet low in oxalate for a total of 11 days and collect 2 x 24 hour urines on days 8 and 9
Oral load of oxalate and sucralose after Weight Loss
Subjects will ingest 100mg carbon-13 oxalate, and 1 gram of sucralose on day 10 of the 11-day low oxalate diet phase. Following the oral load, blood and urine will be collected every 30 minutes and hourly, respectively
University of Alabama at Birmingham, Birmingham
University of Texas Southwestern Medical Center
OTHER
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
University of Alabama at Birmingham
OTHER