Surgical Site Infection and Antibiotic Use Study

NACompletedINTERVENTIONAL
Enrollment

235

Participants

Timeline

Start Date

May 7, 2021

Primary Completion Date

December 31, 2023

Study Completion Date

May 20, 2024

Conditions
Surgical Site InfectionBreast ReconstructionAntibiotic Use
Interventions
DRUG

Single pre-operative dose of intravenous antibiotics with intraoperative redosing

Intravenous cefazolin, a cephalosporin antibiotic, will be prescribed to all patients before surgery. In case of allergy to cefazolin, intravenous clindamycin will be prescribed. For allergy to both antibiotics, an appropriate antibiotic should be chosen by the surgeon and documented. All patients will receive one dose of antibiotic within 60 minutes prior to incision, and any intraoperative doses of antibiotics according to current recommendations based on the antibiotic's dosing and on operative time.

DRUG

One week of post-operative antibiotics

The patients will be prescribed one week of Cephalosporin Antibiotic (Keflex/Duricef/Other) of their surgeon's choice.

Trial Locations (5)

21205

Johns Hopkins University, Baltimore

27710

Duke University Medical Center, Durham

44195

Cleveland Clinic Foundation, Cleveland

48109

University of Michigan, Ann Arbor

60637

The University of Chicago, Chicago

All Listed Sponsors
lead

The Plastic Surgery Foundation

OTHER