Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

249

Participants

Timeline

Start Date

November 12, 2021

Primary Completion Date

September 30, 2027

Study Completion Date

September 30, 2027

Conditions
Renal Pelvis and Ureter Urothelial Carcinoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo tissue biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Doxorubicin Hydrochloride

Given Iv

BIOLOGICAL

Durvalumab

Given IV

DRUG

Gemcitabine Hydrochloride

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Methotrexate

Given IV

BIOLOGICAL

Pegfilgrastim

Given via injection

PROCEDURE

Therapeutic Conventional Surgery

Undergo surgery

DRUG

Vinblastine Sulfate

Given Iv

Trial Locations (256)

14263

ACTIVE_NOT_RECRUITING

Roswell Park Cancer Institute, Buffalo

15146

RECRUITING

UPMC Hillman Cancer Center - Monroeville, Monroeville

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

15243

RECRUITING

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15301

RECRUITING

UPMC Cancer Center-Washington, Washington

15601

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

19104

RECRUITING

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19611

RECRUITING

Reading Hospital, West Reading

20010

RECRUITING

MedStar Washington Hospital Center, Washington D.C.

20016

RECRUITING

Sibley Memorial Hospital, Washington D.C.

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

25304

RECRUITING

West Virginia University Charleston Division, Charleston

27157

ACTIVE_NOT_RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27534

RECRUITING

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

28328

RECRUITING

Southeastern Medical Oncology Center-Clinton, Clinton

28546

RECRUITING

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29425

ACTIVE_NOT_RECRUITING

Medical University of South Carolina, Charleston

30033

RECRUITING

Emory Decatur Hospital, Decatur

30308

RECRUITING

Emory University Hospital Midtown, Atlanta

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43560

RECRUITING

ProMedica Flower Hospital, Sylvania

45005

ACTIVE_NOT_RECRUITING

Dayton Physicians LLC-Atrium, Franklin

45331

RECRUITING

Miami Valley Cancer Care and Infusion, Greenville

45373

RECRUITING

Upper Valley Medical Center, Troy

45409

RECRUITING

Miami Valley Hospital, Dayton

RECRUITING

Premier Blood and Cancer Center, Dayton

ACTIVE_NOT_RECRUITING

Greater Dayton Cancer Center, Kettering

45415

ACTIVE_NOT_RECRUITING

Dayton Physician LLC - Englewood, Dayton

RECRUITING

Miami Valley Hospital North, Dayton

45429

ACTIVE_NOT_RECRUITING

Kettering Medical Center, Kettering

45459

ACTIVE_NOT_RECRUITING

Dayton Physicians LLC-Miami Valley South, Centerville

RECRUITING

Miami Valley Hospital South, Centerville

45504

SUSPENDED

Springfield Regional Cancer Center, Springfield

45840

ACTIVE_NOT_RECRUITING

Armes Family Cancer Center, Findlay

47374

ACTIVE_NOT_RECRUITING

Reid Health, Richmond

48044

RECRUITING

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

RECRUITING

Huron Gastroenterology PC, Ypsilanti

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

SUSPENDED

Hope Cancer Clinic, Livonia

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48341

RECRUITING

Michigan Healthcare Professionals Pontiac, Pontiac

RECRUITING

Newland Medical Associates-Pontiac, Pontiac

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48346

RECRUITING

Hematology Oncology Consultants-Clarkston, Clarkston

RECRUITING

Newland Medical Associates-Clarkston, Clarkston

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48601

RECRUITING

MyMichigan Medical Center Saginaw, Saginaw

48604

SUSPENDED

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

SUSPENDED

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48764

RECRUITING

MyMichigan Medical Center Tawas, Tawas City

50010

ACTIVE_NOT_RECRUITING

Mary Greeley Medical Center, Ames

ACTIVE_NOT_RECRUITING

McFarland Clinic - Ames, Ames

50036

ACTIVE_NOT_RECRUITING

McFarland Clinic - Boone, Boone

50129

ACTIVE_NOT_RECRUITING

McFarland Clinic - Jefferson, Jefferson

50158

ACTIVE_NOT_RECRUITING

McFarland Clinic - Marshalltown, Marshalltown

50501

ACTIVE_NOT_RECRUITING

McFarland Clinic - Trinity Cancer Center, Fort Dodge

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

52722

RECRUITING

University of Iowa Healthcare Cancer Services Quad Cities, Bettendorf

53022

RECRUITING

Aurora Health Care Germantown Health Center, Germantown

53024

RECRUITING

Aurora Cancer Care-Grafton, Grafton

53066

RECRUITING

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

RECRUITING

Aurora Medical Center in Summit, Summit

53081

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

RECRUITING

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53142

RECRUITING

Aurora Cancer Care-Kenosha South, Kenosha

53149

RECRUITING

ProHealth D N Greenwald Center, Mukwonago

53188

RECRUITING

ProHealth Waukesha Memorial Hospital, Waukesha

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

53209

RECRUITING

Aurora Cancer Care-Milwaukee, Milwaukee

53215

RECRUITING

Aurora Saint Luke's Medical Center, Milwaukee

53226

RECRUITING

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

RECRUITING

Aurora West Allis Medical Center, West Allis

53233

RECRUITING

Aurora Sinai Medical Center, Milwaukee

53406

RECRUITING

Aurora Cancer Care-Racine, Racine

54017

SUSPENDED

Cancer Center of Western Wisconsin, New Richmond

54143

RECRUITING

Aurora Bay Area Medical Group-Marinette, Marinette

54241

RECRUITING

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

RECRUITING

Aurora BayCare Medical Center, Green Bay

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

54904

RECRUITING

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

54981

RECRUITING

ThedaCare Cancer Care - Waupaca, Waupaca

55008

SUSPENDED

Cambridge Medical Center, Cambridge

55082

RECRUITING

Lakeview Hospital, Stillwater

55092

SUSPENDED

Fairview Lakes Medical Center, Wyoming

55101

RECRUITING

Regions Hospital, Saint Paul

55102

SUSPENDED

United Hospital, Saint Paul

55109

RECRUITING

Minnesota Oncology Hematology PA-Maplewood, Maplewood

SUSPENDED

Saint John's Hospital - Healtheast, Maplewood

55125

SUSPENDED

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

SUSPENDED

Fairview Ridges Hospital, Burnsville

SUSPENDED

Minnesota Oncology - Burnsville, Burnsville

55362

SUSPENDED

Monticello Cancer Center, Monticello

55369

SUSPENDED

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55371

SUSPENDED

Fairview Northland Medical Center, Princeton

55379

SUSPENDED

Saint Francis Regional Medical Center, Shakopee

55387

SUSPENDED

Ridgeview Medical Center, Waconia

55407

SUSPENDED

Abbott-Northwestern Hospital, Minneapolis

55415

SUSPENDED

Hennepin County Medical Center, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

SUSPENDED

North Memorial Medical Health Center, Robbinsdale

55432

ACTIVE_NOT_RECRUITING

Unity Hospital, Fridley

55433

RECRUITING

Mercy Hospital, Coon Rapids

55435

SUSPENDED

Fairview Southdale Hospital, Edina

55454

SUSPENDED

Health Partners Inc, Minneapolis

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

56073

SUSPENDED

New Ulm Medical Center, New Ulm

56201

SUSPENDED

Rice Memorial Hospital, Willmar

60010

RECRUITING

Advocate Good Shepherd Hospital, Barrington

60014

RECRUITING

AMG Crystal Lake - Oncology, Crystal Lake

60048

RECRUITING

AMG Libertyville - Oncology, Libertyville

60068

RECRUITING

Advocate Lutheran General Hospital, Park Ridge

60123

RECRUITING

Advocate Sherman Hospital, Elgin

60153

ACTIVE_NOT_RECRUITING

Loyola University Medical Center, Maywood

60160

ACTIVE_NOT_RECRUITING

Marjorie Weinberg Cancer Center at Loyola-Gottlieb, Melrose Park

60429

RECRUITING

Advocate South Suburban Hospital, Hazel Crest

60491

ACTIVE_NOT_RECRUITING

Loyola Medicine Homer Glen, Homer Glen

60515

RECRUITING

Advocate Good Samaritan Hospital, Downers Grove

60527

ACTIVE_NOT_RECRUITING

Loyola Center for Health at Burr Ridge, Burr Ridge

60657

RECRUITING

Advocate Illinois Masonic Medical Center, Chicago

61021

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Peru, Peru

SUSPENDED

Valley Radiation Oncology, Peru

61356

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Galesburg, Galesburg

SUSPENDED

Western Illinois Cancer Treatment Center, Galesburg

61443

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Canton, Canton

61530

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

ACTIVE_NOT_RECRUITING

Illinois CancerCare - Washington, Washington

61615

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Peoria, Peoria

61636

SUSPENDED

Methodist Medical Center of Illinois, Peoria

61704

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Bloomington, Bloomington

61801

SUSPENDED

Carle Cancer Center, Urbana

61832

SUSPENDED

Carle at The Riverfront, Danville

61938

SUSPENDED

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

SUSPENDED

OSF Saint Anthony's Health Center, Alton

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62321

ACTIVE_NOT_RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

SUSPENDED

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

SUSPENDED

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

SUSPENDED

Springfield Memorial Hospital, Springfield

62801

SUSPENDED

Centralia Oncology Clinic, Centralia

62864

SUSPENDED

SSM Health Good Samaritan, Mount Vernon

62902

SUSPENDED

Memorial Hospital of Carbondale, Carbondale

62918

RECRUITING

SIH Cancer Institute, Carterville

63011

SUSPENDED

Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63090

SUSPENDED

Mercy Hospital Washington, Washington

63109

SUSPENDED

Mercy Infusion Center - Chippewa, St Louis

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

RECRUITING

Mercy Hospital South, St Louis

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63141

RECRUITING

Mercy Hospital Saint Louis, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

SUSPENDED

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

RECRUITING

Saint Francis Medical Center, Cape Girardeau

64506

SUSPENDED

Heartland Regional Medical Center, Saint Joseph

64804

SUSPENDED

Freeman Health System, Joplin

SUSPENDED

Mercy Hospital Joplin, Joplin

65109

SUSPENDED

MU Health Care Goldschmidt Cancer Center, Jefferson City

65401

SUSPENDED

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

SUSPENDED

Phelps Health Delbert Day Cancer Institute, Rolla

65613

SUSPENDED

Central Care Cancer Center - Bolivar, Bolivar

65804

SUSPENDED

Mercy Hospital Springfield, Springfield

65807

SUSPENDED

CoxHealth South Hospital, Springfield

67530

SUSPENDED

Central Care Cancer Center - Great Bend, Great Bend

67846

SUSPENDED

Central Care Cancer Center - Garden City, Garden City

70002

RECRUITING

Mary Bird Perkins Cancer Center - Metairie, Metairie

70006

RECRUITING

East Jefferson General Hospital, Metairie

RECRUITING

LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie

70112

RECRUITING

University Medical Center New Orleans, New Orleans

70809

RECRUITING

Mary Bird Perkins Cancer Center, Baton Rouge

72205

ACTIVE_NOT_RECRUITING

University of Arkansas for Medical Sciences, Little Rock

72903

SUSPENDED

Mercy Hospital Fort Smith, Fort Smith

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

73120

SUSPENDED

Mercy Hospital Oklahoma City, Oklahoma City

73505

RECRUITING

Cancer Centers of Southwest Oklahoma Research, Lawton

75080

RECRUITING

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75235

RECRUITING

Parkland Memorial Hospital, Dallas

75237

RECRUITING

UT Southwestern Simmons Cancer Center - RedBird, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

80124

RECRUITING

UCHealth Lone Tree Health Center, Lone Tree

80129

RECRUITING

UCHealth Highlands Ranch Hospital, Highlands Ranch

80206

RECRUITING

UCHealth - Cherry Creek, Denver

80524

RECRUITING

Poudre Valley Hospital, Fort Collins

80528

RECRUITING

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

RECRUITING

Medical Center of the Rockies, Loveland

80631

RECRUITING

UCHealth Greeley Hospital, Greeley

86401

RECRUITING

Kingman Regional Medical Center, Kingman

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

89052

RECRUITING

OptumCare Cancer Care at Seven Hills, Henderson

89102

RECRUITING

OptumCare Cancer Care at Charleston, Las Vegas

89148

RECRUITING

OptumCare Cancer Care at Fort Apache, Las Vegas

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92103

RECRUITING

UC San Diego Medical Center - Hillcrest, San Diego

94040

ACTIVE_NOT_RECRUITING

Palo Alto Medical Foundation-Camino Division, Mountain View

94086

ACTIVE_NOT_RECRUITING

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

ACTIVE_NOT_RECRUITING

California Pacific Medical Center-Pacific Campus, San Francisco

94301

ACTIVE_NOT_RECRUITING

Palo Alto Medical Foundation Health Care, Palo Alto

94304

RECRUITING

Stanford Cancer Institute Palo Alto, Palo Alto

94538

ACTIVE_NOT_RECRUITING

Palo Alto Medical Foundation-Fremont, Fremont

94589

ACTIVE_NOT_RECRUITING

Sutter Solano Medical Center/Cancer Center, Vallejo

94704

ACTIVE_NOT_RECRUITING

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95065

ACTIVE_NOT_RECRUITING

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95355

ACTIVE_NOT_RECRUITING

Memorial Medical Center, Modesto

95403

ACTIVE_NOT_RECRUITING

Sutter Pacific Medical Foundation, Santa Rosa

95602

ACTIVE_NOT_RECRUITING

Sutter Auburn Faith Hospital, Auburn

95661

ACTIVE_NOT_RECRUITING

Sutter Roseville Medical Center, Roseville

95816

ACTIVE_NOT_RECRUITING

Sutter Medical Center Sacramento, Sacramento

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

98195

RECRUITING

University of Washington Medical Center - Montlake, Seattle

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

60453-2699

RECRUITING

Advocate Christ Medical Center, Oak Lawn

04330

RECRUITING

Harold Alfond Center for Cancer Care, Augusta

04005

SUSPENDED

MaineHealth Maine Medical Center - Biddeford, Biddeford

04073

RECRUITING

MaineHealth Cancer Care and IV Therapy - Sanford, Sanford

RECRUITING

MaineHealth Cancer Care Center of York County, Sanford

04106

RECRUITING

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

01655

RECRUITING

UMass Memorial Medical Center - University Campus, Worcester

07601

COMPLETED

Hackensack University Medical Center, Hackensack

07039

SUSPENDED

Saint Barnabas Medical Center, Livingston

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

08755

RECRUITING

Community Medical Center, Toms River

45005-1066

RECRUITING

Atrium Medical Center-Middletown Regional Hospital, Franklin

17033-0850

RECRUITING

Penn State Milton S Hershey Medical Center, Hershey

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH