A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

556

Participants

Timeline

Start Date

January 13, 2021

Primary Completion Date

October 13, 2025

Study Completion Date

April 30, 2028

Conditions
Diffuse Large B-cell Lymphoma
Interventions
BIOLOGICAL

Epcoritamab

Following mandatory pre-medication, participants will be administered epcoritamab as a subcutaneous injection.

DRUG

Investigator's Choice Chemotherapy

Following mandatory pre-medication, participants will be administered intravenously either BR or R-GemOx.

Trial Locations (208)

23298

Virginia Commonwealth University (VCU) Massey Cancer Center, Richmond

27157

Wake Forest Baptist Health, Winston-Salem

40536

University of Kentucky Markey Cancer Center, Lexington

45229

The Christ Hospital Cancer Center, Cincinnati

45247

TriHealth Cancer Institute- Good Samaritan Hospital, Cincinnati

46237

Indiana Blood and Marrow Transplantation, Indianapolis

46250

Community Health Network Cancer Center North, Indianapolis

49201

Henry Ford Health System, Jackson

53188

Waukesha Memorial Hospital, Waukesha

55416

MMCORC Attn Delaney Anderson, Saint Louis Park

78234

Brooke Army Medical Center, Fort Sam Houston

84143

LDS Hospital, Salt Lake City

84405

Community Cancer Trials of Utah, Ogden

98902

North Star Lodge Cancer Center, Yakima

08103

MD Anderson Cancer Center at Cooper, Camden

Unknown

Flinders Medical Centre, Bedford Park

Concord Repatriation General Hospital, Concord

Peninsula Private Hospital Clinical Trials Unit, Frankston

Icon Cancer Centre Corporate Office, South Brisbane

Calvary Mater Newcastle, Waratah

Westmead Hospital, Westmead

Ordensklinikum Linz Barmherzige Schwestern, Linz

Ordensklinikum Linz GmbH Elisabethinen, Linz

Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III der PMU, Salzburg

ZNA Middelheim, Antwerp

AZ Sint-Jan, Bruges

Institut Jules Bordet, Brussels

Universitair Ziekenhuis Gent, Ghent

UZ Brussel, Jette

Hôpital de Jolimont, La Louvière

Universitair Ziekenhuis gasthuisberg Leuven, Leuven

AZ Nikolaas- Verenigde Ziekenhuizen van Waas en Durme, Sint-Niklaas

AZ Turnhout, Campus Sint-Elisabeth, Turnhout

CHU de Quebec-Universite Laval, Québec

Affiliated Hospital of Hebei University, Baoding

Beijing Cancer Hospital, Beijing

Beijing Tongren Hospital, Capital Medical University, Beijing

The First Hospital of Jilin University, Changchun

West China Hospital, Sichuan University, Chengdu

The Second Hospital of Dalian Medical University, Dalian

Guangdong Provincial Peoples Hospital, Guangdong

Guangxi Medical University Affiliated Tumor Hospital, Guangxi

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

Hubei Cancer Hospital, Hubei

Hunan Cancer Hospital, Hunan

The First Affiliated Hospital of Nanchang University, Nanchang

Qingdao Central Hospital, Qingdao

Shanxi Provincial Cancer Hospital, Shanxi

Shengjing Hospital of China Medical University, Shenyang

Shenzhen Peoples Hospital, Shenzhen

The First Affiliated Hospital of Soochow University, Suzhou

Tianjin Medical University Cancer Institute and Hospital, Tianjin

EC of Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

Yantai Yuhuangding Hospital, Yantai

Henan Cancer Hospital, Zhengzhou

The Second Affiliated Hospital Zhejiang University School of Medicine, Zhenjiang

Aalborg Universitetshospital, Aalborg

Aarhus University Hospital, Department of Hematology, Clinical Research Unit C116, Aarhus

Clinical Research Unit, Roskilde Sygehus, Roskilde

Vejle Hospital, Vejle

HUS Cancer Center/ Clinical Trial Unit, Helsinki

Oulu university hospital, Department of hematology, Oulu

Audrey ALEME, Amiens

Centre Hospitalier de la Côte Basque, Bayonne

CHRU de Brest - Hospital Morvan, Brest

CHU Caen - IHBN, Caen

Groupe Hospitalier de La Rochelle, La Rochelle

CHU de LIMOGES, Limoges

Centre Léon Bérard, Lyon

Hopital de la Conception APHM, Marseille

CHU de Nantes - Hôtel Dieu, Nantes

Centre Antoine Lacassagne, Nice

Clinique Victor Hugo, Paris

Hôpital Saint-Louis, Paris

CHU de Bordeaux Hôpital Haut-Lévêque, Pessac

Centre Hospitalier Lyon Sud, Pierre-Bénite

CHU de Poitiers - Hôpital la Milétrie, Poitiers

Centre Hospitalier Rene Dubos, Pontoise

Ch Cornouaille, Quimper

Centre Henri Becquerel, Rouen

CHRU Tours Hôpital Bretonneau, Tours

Uniklinik Köln, Klinik I für Innere Medizin, CIO Gebäude 70, 5.094, Cologne

Universitaetsklinikum Essen, Essen

Universitätsklinikum Schleswig-Holstein Medizinische Klinik II Hämatologie und Onkologie, Kiel

Universitätsklinikum Würzburg, Würzburg

National Institute of Oncology, Budapest

Semmelweis Egyetem Belgyógyászati és Onkológiai Klinika, Budapest

Debreceni Egyetem Klinikai Kozpont, Belgyogyaszati Klinika, Hematologia, Debrecen

Belgyógyászati osztály Markhot Ferenc Kórház, Eger

Petz Aladar Egyetemi Oktato Korhaz, Győr

Josa Andras Teaching Hospital, Hematology Dept, Nyíregyháza

University of Pecs 1st. Internal medicine Clinic Dept. Hematology, Pécs

Szegedi Tudományegyetem II. sz. Belgyogyaszat, Hematologia, Szeged

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz, Székesfehérvár

Bnai Zion Medical Center, Haifa

Rambam Health Care Center, Haifa

Hadassah University Hospital, Jerusalem

Shaare Zedek Medical Center, Jerusalem

Sourasky Medical Center, Tel Aviv

IRCCS Istituto Tumori Giovanni Paolo II Bari, Bari

Azienda Socio Sanitaria Territoriale Sette Laghi (Presidio Ospedale di Circolo e Fondazione Macchi), Bergamo

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili), Brescia

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), Meldola

Istituto Oncologico Europeo, Milan

San Raffaele Hospital, Milan

Azienda Ospedaliero - Universitaria Maggiore delle Carita SCDU Ematologia building C, Novara

Fondazione IRCCS Policlinico San matteo, Pavia

Ospedale Santa Maria delle Croci, Ravenna

Azienda Ospedaliera Universitaria Policlinico Umberto I Università di Roma La Sapienza, Dip Med Tra, Rome

IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo

Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI) Ospedale Maggiore di Trieste, Trieste

SC di Ematologia - AON SS Antonio e Biagio e Cesare Arrigo, Venezia

Kyushu University Hospital, Fukuoka

Fukushima Medical University Hospital, Fukushima

Chugoku Central Hospital, Fukuyama

Hokkaido University Hospital, Hokkaido

National Cancer Center Hospital East, Kashiwa

Kyoto University Medical Hospital, Kyoto

Matsuyama Red Cross Hospital, Matsuyama

Mie University Hospital, Mie

Japanese Red Cross Nagoya Daini Hospital, Nagoya

NHO Nagoya Medical Center, Nagoya

Okayama University Hospital, Okayama

Kindai University Hospital, Ōsaka-sayama

Tohoku University Hospital, Sendai

Keio University Hospital, Tokyo

National Cancer Center Hospital, Tokyo

Tokai University Hospital, Tokyo

Fujita Health University Hospital, Toyoake

Yamagata University Hospital, Yamagata

Rijnstate Arnhem, Arnhem

Amphia Ziekenhuis, Interne Geneeskunde, Oncologie. Route 43, Breda

Albert Schweitzer Ziekenhuis, Dordrecht

Admiraal de Ruyter Ziekenhuis, Goes

Bravis Ziekenhuis, Roosendaal

Erasmus MC, Rotterdam

Franciscus Gasthuis And Vlietland, Rotterdam

Oslo University Hospital location Radium hospital, Oslo

St. Olavs Hospital HF, Trondheim

Uniwersyteckie Centrum Kliniczne, Klinika Hematologii i Transplantologii, Gdansk

Pratia Onkologia Katowice, Katowice

Pratia MCM Kraków, Krakow

Instytut Centrum Zdrowia Matki Polki, Lodz

Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii, Lodz

Centrum Medyczne Pratia Poznan, Skorzewo

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu, Wroclaw

State Autonomous Institution of Healthcare Republican Clinical Oncological Dispensary of the Ministr, Kazan'

Federal State Budgetary Institution of Science, Moscow

Federal State Budgetary Institution, Moscow

State Budgetary Institution of Healthcare of Nizhniy Novgorod region, 1st inpatient facility, 5th fl, Nizhny Novgorod

Federal State Budgetary Institution V.A. Almazov National Medical Research Center of the Ministry of, Saint Petersburg

State Budgetary Institution of Healthcare Leningrad Regional Clinical Hospital, Saint Petersburg

National University Hospital, Kent Ridge

Clinical Trials and Research Centre, Singapore

National Cancer Centre Singapore, Singapore

Dong-A University Hospital, Busan

Pusan National University Hospital, Busan

Pusan National University Hosptial, Busan

Keimyung University Dongsan Hospital, Daegu

Chonbuk National University Hospital, Geumam

Asan Medical Center, Seoul

Samsung Medical Center, Seoul

Seoul National University Bundang Hospital, Seoul

Seoul National University Hospital, Seoul

Severance Hospital, Yonsei University Health System, Seoul

The Catholic University of Korea Seoul St. Marys Hospital, Seoul

Ulsan University Hospital, Ulsan

ICO Badalona - Hospital Universitari Germans Trias i Pujol, Badalona

ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona

Hospita Universitario Puerta Del Mar, Cadiz

Hospital San Pedro de Alcántara, Cáceres

Hospital Universitario Reina Sofía, Córdoba

Hospital Arnau de Vilanova, Lleida

Hospital Universitario 12 de Octubre, Madrid

Hospital Universitario Fundacion Jimenez Diaz, Madrid

Hospital Universitario Ramon y Cajal, Madrid

Md Anderson Cancer Center, Madrid

Hospital Universitario de Salamanca, Salamanca

Hospital Universitario Marqués de Valdecilla, Santander

Hospital Universitario Virgen De Valme, Seville

Hospital Universitario Virgen del Rocío, Seville

Hospital Universitario Virgen Macarena, Seville

Karolinska university Hospital, Stockholm

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

National Cheng Kung University Hospital, Tainan City

National Taiwan University Hospital, Taipei

Taipei Veterans General Hospital, Taipei

Tri-Service General Hospital, Taipei

Ankara University Medical Faculty, Ankara

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi, Ankara

Gazi University Medical Faculty, Ankara

Amerikan Hospital, Istanbul

Iqvia Tibbi Istatistik, Istanbul

Istanbul University Cerrahpasa - Cerrahpasa Tip Fakultesi, Istanbul

Istanbul University Medical Faculty, Istanbul

Dokuz Eylul University Medical Faculty, Izmir

Ege University Medical Faculty, Izmir

Tekirdag Namik Kemal University, Tekirdağ

Karadeniz Technical University, Trabzon

Haematology - University Hospitals Birmingham NHS Foundation Trust, Birmingham

Guys and St Thomas NHS Foundation Trust, London

Hammersmith Hospital, London

Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich

Nottingham University Hospitals NHS Trust, Nottingham

Derriford Hospital, Plymouth

University Hospital Southampton, Southampton

Royal Marsden NHS Foundation Trust (Sutton), Sutton

Royal Cornwall Hospital, Truro

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AbbVie

INDUSTRY

lead

Genmab

INDUSTRY