192
Participants
Start Date
March 23, 2021
Primary Completion Date
December 1, 2025
Study Completion Date
December 1, 2025
Cardiac MRI scan
Cardiac MRI scan pre- and post- aortic valve replacement to assess degree of left ventricular remodelling, fibrosis and myocardial blood flow.
Serum biomarkers (High sensitivity troponin, NT-proBNP
Blood tests looking evidence of cardiac structural remodelling and function.
Implantable Loop Recorder
Determine post-AVR arrhythmia burden
6 minute walk test
Validated assessment of functional capacity - distance walked over 6 minute time frame.
Echocardiogram
Ultrasound assessment of heart structure and function. Standard of care in valve surgery pathway.
RECRUITING
Barts Heart Centre, London
Barts & The London NHS Trust
OTHER
University College, London
OTHER