Mechanisms of Excess Risk in Aortic Stenosis

RecruitingOBSERVATIONAL
Enrollment

192

Participants

Timeline

Start Date

March 23, 2021

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2025

Conditions
Aortic StenosisNon-Sustained VTHeart Failure
Interventions
DIAGNOSTIC_TEST

Cardiac MRI scan

Cardiac MRI scan pre- and post- aortic valve replacement to assess degree of left ventricular remodelling, fibrosis and myocardial blood flow.

DIAGNOSTIC_TEST

Serum biomarkers (High sensitivity troponin, NT-proBNP

Blood tests looking evidence of cardiac structural remodelling and function.

PROCEDURE

Implantable Loop Recorder

Determine post-AVR arrhythmia burden

DIAGNOSTIC_TEST

6 minute walk test

Validated assessment of functional capacity - distance walked over 6 minute time frame.

DIAGNOSTIC_TEST

Echocardiogram

Ultrasound assessment of heart structure and function. Standard of care in valve surgery pathway.

Trial Locations (1)

EC1A 7BE

RECRUITING

Barts Heart Centre, London

All Listed Sponsors
collaborator

Barts & The London NHS Trust

OTHER

lead

University College, London

OTHER