FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

1,672

Participants

Timeline

Start Date

September 17, 2020

Primary Completion Date

June 30, 2030

Study Completion Date

June 30, 2030

Conditions
Rhabdomyosarcoma
Interventions
DRUG

Irinotecan

antineoplastic enzyme inhibitor

DRUG

Actinomycin D

Antineoplastic agent that is a polypeptide antibiotic

DRUG

Doxorubicin

An anthracycline topoisomerase inhibitor isolated from streptpmyces peucetius var. casesius

DRUG

Ifosfamide

chemotherapeutic agent chemically related to the nitrogen mustards and is a synthetic analog of cyclophosphamide

DRUG

Vincristine

anti neoplastic vinca alkaloid agent

DRUG

Vinorelbine

vinca alkaloid with a role as an antineoplastic agent

DRUG

Cyclophosphamide

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent

DRUG

Temozolomide

oral antineoplastic alkylating agent

RADIATION

radiotherapy

Ionising radiation

DRUG

Regorafenib

Oral multi-kinase inhibitor that targets a broad range of angiogenic, stromal and oncogenic kinases, including vascular endothelial growth factor receptors (VEFGR) 1, 2 and 3, tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 (TIE2), platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptors (FGFR), c-KIT, RET, RAF-1 and BRAF (wild-type and V600E mutant).

Trial Locations (128)

2310

RECRUITING

John Hunter Children's Hospital, New Lambton Heights

4101

RECRUITING

Queensland Children's Hospital, Brisbane

28009

RECRUITING

Hospital Del Nino Jesus, Madrid

RECRUITING

Hospital Universitario Gregorio Maranon, Madrid

46026

RECRUITING

Hospital Politecnico U La Fe, Valencia

48903

RECRUITING

Hospital De Cruces, Bilbao

94805

RECRUITING

Gustave Roussy, Villejuif

Unknown

RECRUITING

Chris O'brien Lifehouse, Camperdown

RECRUITING

Monash Children's Hospital, Clayton

RECRUITING

Peter Maccallum Cancer Centre, Melbourne

RECRUITING

Royal Childrens Hospital Melbourne, Melbourne

RECRUITING

Perth Children's Hospital, Perth

RECRUITING

Sydney Children's Hospital, Sydney

RECRUITING

The Childrens Hospital At Westmead, Sydney

RECRUITING

Westmead Hospital, Westmead

RECRUITING

Princess Alexandra Hospital, Woolloongabba

RECRUITING

Kepler University Clinic Linz, Linz

RECRUITING

St Anna Childrens Hospital, Vienna

RECRUITING

Cliniques Universitaires Saint Luc, Brussels

RECRUITING

Hopital Universitaire Des Enfants Reine Fabiola, Brussels

RECRUITING

Universitair Ziekenhuis Gent, Ghent

RECRUITING

Uz Leuven Campus Gasthuisberg, Leuven

RECRUITING

Centre Hospitalier Regional De La Citadelle, Liège

RECRUITING

Clinique Chc Montlegia, Liège

RECRUITING

Aarhus University Hospital, Aarhus

RECRUITING

University Hospital Rigshospitalet, Copenhagen

RECRUITING

Centre Hospitalier Universitaire D'angers, Angers

RECRUITING

Centre Hospitalier Regional Universitaire Besancon - Hopital Jean Minjoz, Besançon

RECRUITING

Centre Hospitalier Universitaire De Bordeaux - Hopital Pellegrin, Bordeaux

RECRUITING

Centre Hospitalier Regional Universitaire Brest - Hopital Morvan, Brest

RECRUITING

Centre Francois Baclesse, Caen

RECRUITING

Centre Hospitalier Universitaire De Caen, Caen

RECRUITING

Centre Hospitalier Universitaire Dijon Bourgogne - Hopital D'enfants, Dijon

RECRUITING

Centre Hospitalier Universitaire De Grenoble, Grenoble

RECRUITING

Centre Hospitalier Universitaire La Reunion, La Réunion

RECRUITING

Centre Oscar Lambret, Lille

RECRUITING

Centre Leon Berard, Lyon

RECRUITING

Hopital De La Timone (ap-hm), Marseille

RECRUITING

Centre Hospitalier Universitaire De Nancy, Nancy

RECRUITING

Centre Hospitalier Universitaire De Nantes, Nantes

RECRUITING

Hopital Armand Trousseau, Paris

RECRUITING

Institut Curie, Paris

RECRUITING

Centre Hospitalier Universitaire Haut Levque, Pessac

RECRUITING

Centre Hospitalier Universitaire De Poitiers, Poitiers

RECRUITING

Chu De Reims, Reims

RECRUITING

Centre Eugne Marquis De Rennes, Rennes

RECRUITING

Centre Hospitalier Universitaire De Rennes - Hopital Pontchaillou, Rennes

RECRUITING

Centre Hospitalier Universitaire De Rouen, Rouen

RECRUITING

Centre Hospitalier Universitaire Saint-etienne, Saint-Etienne

RECRUITING

Strasbourg Hautepierre, Strasbourg

RECRUITING

Centre Hospitalier Universitaire De Toulouse - Hopital Des Enfants, Toulouse

RECRUITING

Centre Hospitalier Regional Universitaire De Tours - Hopital Clocheville, Tours

RECRUITING

Department of Pediatric Hematology-oncology - Aghia Sophia Children's Hospital, Athens

RECRUITING

Hellenic Society of Pediatric Hematology- Oncology, Athens

RECRUITING

University Unit of Pediatric Oncology-hematology - Children's Hospital Agia Sophia, Athens

RECRUITING

Ahepa University General Hospital of Thessaloniki, Thessaloniki

RECRUITING

Ippokratio General Hospital of Thessaloniki, Thessaloniki

NOT_YET_RECRUITING

Our Lady's Children's Hospital, Crumlin

RECRUITING

Rambam Health Care Campus, Haifa

RECRUITING

Hadassah University Medical Centre, Jerusalem

RECRUITING

Schneider Medical Centre, Petah Tikva

RECRUITING

Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv

RECRUITING

Chaim Sheba Medical Centre, Tel Litwinsky

NOT_YET_RECRUITING

University Hospital of Padova (azienda Ospedaliera of Padua), Padua

RECRUITING

University Medical Centre Groningen, Groningen

RECRUITING

Prinses Maxima Centrum Voor Kinderoncologie, Utrecht

RECRUITING

Starship Children's Health, Auckland

RECRUITING

Christchurch Hospital, Christchurch

RECRUITING

Haukeland University Hospital - Paediatric, Bergen

RECRUITING

Oslo University Hospital - Paediatrics, Oslo

RECRUITING

Oslo University Hospital - Radiumhospitalet, Oslo

RECRUITING

University Hospital of North Norway - Paediatric, Tromsø

RECRUITING

St Olavs Hospital - Paediatric, Trondheim

NOT_YET_RECRUITING

Instituto Portugues De Oncologia De Losbona Francisco Gentil, Epe, Lisbon

NOT_YET_RECRUITING

Bratislava, National Institute for Children's Diseases, Bratislava

RECRUITING

University Childrens Hospital Ljubljana, Ljubljana

RECRUITING

University Medical Centre Ljubjlana, Ljubljana

RECRUITING

Hospital Sant Joan De Deu, Barcelona

RECRUITING

Hospital Universitari Vall D'hebron, Barcelona

RECRUITING

Hospital Universitario La Paz, Madrid

RECRUITING

Hospital Regional Universitario De Malaga, Málaga

RECRUITING

Hospital Virgen Del Rocio, Seville

RECRUITING

Hospital Universitario Miguel Servet Materno - infantil, Zaragoza

RECRUITING

Uppsala University Childrens Hospital, Uppsala

RECRUITING

Kantonsspital Aarau, Aarau

RECRUITING

Universitats-kinderspital Bieder Basel (UKBB), Basel

RECRUITING

Ospedale San Giovanni, Bellinzona

RECRUITING

Inselspital Bern, Bern

RECRUITING

Hug Hopitaux Universitaires De Geneve, Geneva

RECRUITING

Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Lausanne

RECRUITING

Luzerner Kantonspital - Kinderspital Luzern, Lucerne

RECRUITING

Ostschweizer Kinderspital, Sankt Gallen

RECRUITING

Universitaetsspital Zurich, Zurich

RECRUITING

Royal Aberdeen Children's Hospital, Aberdeen

NOT_YET_RECRUITING

Belfast City Hospital, Belfast

NOT_YET_RECRUITING

Royal Belfast Hospital for Sick Children, Belfast

RECRUITING

Birmingham Children's Hospital, Birmingham

NOT_YET_RECRUITING

The Queen Elizabeth Hospital, Birmingham

RECRUITING

Bristol Haematology And Oncology Centre, Bristol

RECRUITING

Bristol Royal Hospital for Children, Bristol

RECRUITING

Addenbrooke's Hospital, Cambridge

RECRUITING

Noah's Ark Children's Hospital for Wales, Cardiff

RECRUITING

Velindre Hospital, Cardiff

RECRUITING

Royal Hospital for Children and Young People, Edinburgh

RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

RECRUITING

Royal Hospital for Children Glasgow, Glasgow

RECRUITING

Leeds General Infirmary, Leeds

RECRUITING

St James's University Hospital, Leeds

RECRUITING

Leicester Royal Infirmary, Leicester

RECRUITING

Alder Hey Children's Hospital, Liverpool

RECRUITING

Great Ormond Street Hospital for Children, London

RECRUITING

Royal Marsden Hospital London, London

RECRUITING

University College London Hospital, London

RECRUITING

Christie Hospital, Manchester

RECRUITING

Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

RECRUITING

Royal Victoria Infirmary, Newcastle upon Tyne

RECRUITING

Nottingham City Hospital, Nottingham

RECRUITING

Queen's Medical Centre, Nottingham, Nottingham

RECRUITING

John Radcliffe Hospital, Oxford

RECRUITING

Sheffield Children's Hospital, Sheffield

NOT_YET_RECRUITING

Weston Park Hospital, Sheffield

RECRUITING

Southampton General Hospital, Southampton

625 00

RECRUITING

Masaryk University Hospital Brno, Brno

115 27

RECRUITING

Children's General Hospital P and A Kyriakou, Athens

151 23

RECRUITING

"Children's and Adolescent's Oncology Clinic, MITERA Children's Hospital", Attiki

715 00

RECRUITING

Hematology-oncology Children's Clinic, University General Hospital of Heraklion, Heraklion

SM2 5PT

RECRUITING

Royal Marsden Hospital, Sutton

M13 9WL

RECRUITING

Royal Manchester Children's Hospital, Manchester

All Listed Sponsors
lead

University of Birmingham

OTHER