A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

225

Participants

Timeline

Start Date

December 21, 2020

Primary Completion Date

November 15, 2024

Study Completion Date

December 31, 2026

Conditions
Low Grade Ovarian Serous AdenocarcinomaOvarian Cancer
Interventions
DRUG

avutometinib (VS-6766)

avutometinib (VS-6766) monotherapy

DRUG

avutometinib (VS-6766) and defactinib

avutometinib (VS-6766) and defactinib combination

Trial Locations (47)

2500

Hopital Jean Minjoz, Besançon

3000

UZ Leuven, Leuven

4000

CHU de Liege, Liège

9000

UZ Gent Medische Oncologie, Ghent

10065

Memorial Sloan Kettering Cancer Center, New York

14004

Hospital Universitario Reina Sofia, Córdoba

20141

Insituto Europeo di Oncologia I.R.C.C.S, Milan

20155

Virginia Cancer Specialists, PC, Gainesville

20769

Maryland Oncology and Hematology, P.A., Glenn Dale

22908

University of Virginia Health System, Charlottesville

28034

Hospital Universitario Ramon y Cajal, Madrid

32804

Advent Health, Orlando

33612

H. Lee Moffitt Cancer Center and Research Institute - Center for Women's Oncology, Tampa

34298

ICM - Val d'Aurelle, Montpellier

35128

U.O.C. Oncologia 2, Istituto Oncologico Veneto I.R.C.C.S., Padua

37203

Sarah Cannon Research Institute, Nashville

43212

The Ohio State University Wexner Medical Center, Columbus

44195

Cleveland Clinic Women's Health Institute, Cleveland

46010

Hospital Clínico Universitario de Valencia, Valencia

55404

Minnesota Oncology Hematology PA, Minneapolis

60637

University of Chicago, Chicago

63110

Washington University School of Medicine, St Louis

69008

Centre Leon Berard, Lyon

73104

University of Oklahoma Medical Center, Oklahoma City

75231

Texas Oncology- Dallas Presbyterian Hospital, Dallas

75248

Institut Curie, Paris

75390

UT Southwestern Medical Center, Dallas

75601

Texas Oncology, Longview

77380

Texas Oncology, The Woodlands

78240

Texas Oncology, San Antonio

78503

Texas Oncology, McAllen

78731

Texas Oncology Austin Central, Austin

85258

Arizona Oncology Associates PC HAL, Scottsdale

87131

University of New Mexico Comprehensive Cancer Center, Albuquerque

89128

Comprehensive Cancer Centers of Nevada, Las Vegas

93105

Sansum Clinic, Santa Barbara

97227

Northwest Cancer Specialists, Portland

97401

Willamette Valley Cancer Institute and Research Center, Eugene

06510

Yale School of Medicine, New Haven

H2X 0A9

Centre de recherche di Centre Hospitalier de i'Universite de Montreal, Montreal

M5G2M9

Princess Margaret Cancer Centre, Toronto

08035

Hospital Universitario Vall D'Hebron, Barcelona

EH4 2XU

Western General Hospital, Edinburgh

G120YN

Beatson West of Scotland Cancer Centre, Glasgow

NW1 2PG

UCLH Cancer Clinical Trials Unit, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

Unknown

Royal Marsden Hospital, Sutton

All Listed Sponsors
collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

collaborator

GOG Foundation

NETWORK

lead

Verastem, Inc.

INDUSTRY