Efficacy and Safety of MK-8189 in Participants With an Acute Episode of Schizophrenia (MK-8189-008)

PHASE2CompletedINTERVENTIONAL
Enrollment

499

Participants

Timeline

Start Date

December 15, 2020

Primary Completion Date

June 21, 2024

Study Completion Date

June 21, 2024

Conditions
Schizophrenia
Interventions
DRUG

MK-8189

MK-8189 administered QD at a dose of 8 mg, 16 mg, or 24 mg via oral tablet.

DRUG

Risperidone

Risperidone administered QD at a dose of 6 mg via oral capsule.

DRUG

Placebo to MK-8189

MK-8189-matching placebo administered QD via oral tablet.

DRUG

Placebo to risperidone

Risperidone-matching placebo administered QD via oral capsule.

Trial Locations (121)

100

National Taiwan University Hospital ( Site 9001), Taipei

110

Taipei City Hospital, Songde Branch ( Site 9004), Taipei

333

Chang Gung Memorial Hospital - Linkou Branch ( Site 9002), Taoyuan District

404

China Medical University Hospital ( Site 9006), Taichung

1000

Center for Mental Health Prof. Nikola Shipkovenski Ltd ( Site 3000), Sofia

1282

"State Psychiatric Hospital Sv. Ivan Rilski, Novi Iskar ( Site 3001)", Novi Iskar

3401

Piejuras Slimnica Psihiatriska Klinika ( Site 8001), Liepāja

5000

Mental Health Center - Veliko Tarnovo ( Site 3006), Veliko Tarnovo

5417

Daugavpils Psihoneirologiska Slimnica ( Site 8005), Daugavpils

6600

State Psychiatric Hospital - Kardzhali ( Site 3005), Kardzhali

7000

Mental Health Center - Ruse, EOOD ( Site 3003), Rousse

8001

Mental Health Center Prof. Dr. Ivan Temkov - Burgas EOOD ( Site 3002), Burgas

10090

Klinika za psihijatriju Vrapce ( Site 4000), Zagreb

Klinika za psihijatriju Vrapce ( Site 4001), Zagreb

Klinika za psihijatriju Sveti Ivan ( Site 4003), Zagreb

10314

Richmond Behavioral Associates ( Site 1064), Staten Island

11000

Clinical Center of Serbia ( Site 5101), Belgrade

Clinical Center of Serbia ( Site 5107), Belgrade

Institut za mentalno zdravlje ( Site 5105), Belgrade

"University Clinical Hospital Center Dr. Dragisa Misovic - Dedinje ( Site 5104)", Belgrade

11217

Taipei Veterans General Hospital ( Site 9000), Taipei

20708

CNE Cherkasy reg. psychiatric hospital of Cherkasy regional council ( Site 7009), Smila

20877

CBH Health ( Site 1044), Gaithersburg

21037

"CNE Vinnytsia Regional Clinical Psycho-neurological hospita-Mixed (men and women) department #2 ( S", Vinnytsia

26220

Special Hospital for Psychiatric Diseases Kovin ( Site 5108), Kovin

Special Hospital for Psychiatric Diseases Kovin ( Site 5109), Kovin

28211

New Hope Clinical Research ( Site 1050), Charlotte

30030

CenExel iResearch, LLC ( Site 1039), Decatur

30331

Atlanta Center For Medical Research ( Site 1022), Atlanta

33016

Behavioral Clinical Research , Inc ( Site 1013), Miami Lakes

33021

Behavioral Clinical Research ( Site 1058), Hollywood

33024

Research Centers of America ( Hollywood )-Central Nervous System (CNS) ( Site 1065), Hollywood

33122

Premier Clinical Research Institute ( Site 1049), Miami

33334

Fort Lauderdale Behavioral Health Center ( Site 1028), Oakland Park

34000

Clinical Center Kragujevac ( Site 5100), Kragujevac

Clinical Center Kragujevac ( Site 5102), Kragujevac

Clinical Center Kragujevac ( Site 5106), Kragujevac

34997

Health Synergy Clinical Research ( Site 1051), Stuart

41944

Kyungpook National University Hospital ( Site 0601), Daegu

44720

Neuro-Behavioral Clinical Research ( Site 1055), North Canton

45417

Midwest Clinical Research ( Site 1059), Dayton

Midwest Clinical Research Center ( Site 1033), Dayton

47392

Inje University Busan Paik Hospital ( Site 0604), Busan

49005

Dnepropetrovsk Regional Clinical Hospital Mechnikov-Regional Centre of Psychosomatic Disorders base, Dnipro

51000

Klinicki bolnicki centar Rijeka ( Site 4005), Rijeka

60622

Ascension Saint Elizabeth ( Site 1000), Chicago

60640

Uptown Research Institute ( Site 1052), Chicago

60641

Pillar Clinical Research, LLC ( Site 1038), Chicago

61068

CNE of Kharkiv Reg. Council Reg. Clinical Psychiatric Hospital Nub 3 ( Site 7012), Kharkiv

Institute of Neurology,Psychiatry and Narcology AMS Ukraine ( Site 7011), Kharkiv

63141

Arch Clinical Trials ( Site 1048), St Louis

71101

Benchmark Research ( Site 1054), Shreveport

72211

Woodland International Research Group, LLC ( Site 1002), Little Rock

72758

Woodland Research Northwest, LLC ( Site 1036), Rogers

73488

CNE. Kherson Regional Psychiatric Hospital ( Site 7004), Kherson

75080

Pillar Clinical Research, LLC ( Site 1004), Richardson

76014

"CNE Precarpathian Regional Clinical Center of Mental Health of Ivano-Frankivsk Regional Council (", Ivano-Frankivsk

78754

Community Clinical Research ( Site 1057), Austin

89102

Altea Research Institute ( Site 1012), Las Vegas

90230

ProScience Research Group ( Site 1046), Culver City

90706

CITRIALS ( Site 1010), Bellflower

91206

Behavioral Research Specialists, LLC ( Site 1032), Glendale

91403

Schuster Medical Research Institute ( Site 1023), Sherman Oaks

92103

Artemis Institute for Clinical Research ( Site 1019), San Diego

92123

California Neuropsychopharmacology Clinical Research Institute, LLC (CNRI-San Diego, LLC) ( Site 103, San Diego

92506

CITRIALS ( Site 1016), Riverside

92845

Collaborative Neuroscience Research, LLC ( Site 1041), Garden Grove

107076

Moscow Scientific Research Institute for Psychiatry ( Site 6013), Moscow

Psychiatric Clinical Hospital 4 named after PB Gannushkin ( Site 6016), Moscow

Psychiatric Clinical Hospital 4 named after PB Gannushkin-Psychiatric department 4 ( Site 6023), Moscow

127083

Central Moscow Regional Clinical Psychiatric Hospital ( Site 6018), Moscow

150003

Yaroslavl Regional Clinical Psychiatry Hospital ( Site 6022), Yaroslavl

163530

Arkhangelsk Regional Psychiatric Clinical Hospital ( Site 6020), Arkhangelsk

188820

SGHI Leningrad Region Psyconeurology Dispensary ( Site 6017), Leningrad Region

192019

Bekhterev Research Institute for Psychoneurology ( Site 6008), Saint Petersburg

197341

SPb City Psychiatric Hospital #3 na II Skvortsov-Stepanov ( Site 6000), Saint Petersburg

SPb City Psychiatric Hospital #3 na II Skvortsov-Stepanov ( Site 6001), Saint Petersburg

SPb City Psychiatric Hospital #3 na II Skvortsov-Stepanov ( Site 6002), Saint Petersburg

357034

Stavropol Region Psychiatric Hospital #2 ( Site 6005), Stavropol

399083

Lipetsk Regional Psychoneurology Hospital ( Site 6021), Lipetsk

634014

Federal State Scientific Institution Research Institute of Mental Health ( Site 6014), Tomsk

700282

Institutul de Psihiatrie Socola ( Site 0810), Iași

Institutul de Psihiatrie Socola ( Site 0814), Iași

3702455

Seimou Hospital ( Site 2004), Tomioka

8360004

Shiranui Hospital ( Site 2043), Omuta

8420192

National Hospital Organization Hizen Psychiatric Medical Center ( Site 2017), Kanzaki-gun

72712-3873

Pillar Clinical Research ( Site 1047), Bentonville

02114

Massachusetts General Hospital ( Site 1035), Boston

08053

Hassman Research Institute Marlton Site ( Site 1040), Marlton

470-1168

Seishinkai Okehazama Hospital Fujita Kokoro Care Center ( Site 2011), Toyoake

272-8516

Kohnodai Hospital, National Center for Global Health and Medicine ( Site 2005), Ichikawa

808-0139

Wakato Hospital ( Site 2031), Kitakyushu

243-0201

Soushu Hospital ( Site 2008), Atsugi

259-1304

Tanzawa Hospital ( Site 2037), Hadano

233-0006

Kanagawa Psychiatric Center ( Site 2035), Yokohama

384-8540

Komoro Kogen Hospital ( Site 2046), Komoro

904-1201

National Hospital Organization Ryukyu Hospital ( Site 2019), Kunigamigun

900-0005

Amekudai Hospital ( Site 2020), Naha

847-0031

Rainbow and Sea Hospital ( Site 2016), Karatsu

192-0153

Ongata Hospital ( Site 2007), Hachiōji

114-0024

Nishigahara Hospital ( Site 2042), Kita-ku

187-8551

National Center of Neurology and Psychiatry ( Site 2023), Kodaira

260-8677

Chiba University Hospital ( Site 2024), Chiba

815-0074

Inokuchi Noma Hospital ( Site 2030), Fukuoka

819-0037

Kuramitsu Hospital ( Site 2014), Fukuoka

861-8002

Yuge Hospital ( Site 2018), Kumamoto

121-8515

Seijin Hospital ( Site 2026), Tokyo

175-0091

Narimasu Kosei Hospital ( Site 2006), Tokyo

61-485

Centrum Medyczne HCP ( Site 0913), Poznan

05-802

Klinika Psychiatryczna Wydzialu Nauki o Zdrowiu WUM ( Site 0900), Pruszków

00-665

Samodzielny Wojewódzki Zespół Publicznych Zakładów Psychiatrycznej Opieki Zdrowotnej w Warszawie ( S, Warsaw

80-211

Uniwersyteckie Centrum Kliniczne ( Site 0902), Gdansk

91-229

Specjal. Psychiatryczny ZOZ w Lodzi, Szpital im. Babinskiego ( Site 0905), Lodz

041914

Prof. Dr. Alexandru Obregia Psychiatry Hospital ( Site 0815), Bucharest

Prof. Dr. Alexandru Obregia Psychiatry Hospital ( Site 0816), Bucharest

Prof. Dr. Alexandru Obregia Psychiatry Hospital ( Site 0817), Bucharest

Prof. Dr. Alexandru Obregia Psychiatry Hospital ( Site 0818), Bucharest

03080

Seoul National University Hospital ( Site 0600), Seoul

02192

Kyiv City Psychoneurological Hospital 2 ( Site 7008), Kyiv

04080

CNE Clinical Hospital PSYCHIATRY of executive body of Kyiv City Council -Kyiv City State Admin ( Sit, Kyiv

08631

MNE of KRC-Regional psychiatric and narcological medical association ( Site 7005), Kyiv

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04624243 - Efficacy and Safety of MK-8189 in Participants With an Acute Episode of Schizophrenia (MK-8189-008) | Biotech Hunter | Biotech Hunter