672
Participants
Start Date
December 8, 2020
Primary Completion Date
October 28, 2027
Study Completion Date
October 28, 2027
Pembrolizumab 200 mg
Pembrolizumab 200 mg Q3W
Pembrolizumab 400 mg
Pembrolizumab 400 mg Q6W
Pembrolizumab placebo (saline)
Pembrolizumab placebo (saline) Q3W
Pembrolizumab placebo (saline)
Pembrolizumab placebo (saline) Q6W
Olaparib 300 mg BID
Olaparib 300 mg twice daily (BID)
Olaparib matching placebo
Olaparib matching placebo BID
Etoposide 100 mg/m^2
Etoposide 100 mg/m\^2 intravenous (IV) Q3W, Day 1-3
Platinum, investigator's choice
Carboplatin titrated to an area under the plasma drug concentration time curve (AUC) of 5 mg/mL/min IV Q3W OR Cisplatin 75 mg/m\^2 IV Q3W on Day 1 of each cycle
Standard Thoracic Radiotherapy
Standard Thoracic Radiotherapy
Prophylactic Cranial Irradiation (PCI)
PCI will be strongly recommended for participants who achieve CR or PR after completion of chemoradiation treatment.
Orszagos Koranyi Pulmonologiai Intezet ( Site 1301), Budapest
Orszagos Onkologiai Intezet ( Site 1310), Budapest
Uzsoki Utcai Korhaz ( Site 1303), Budapest
Saint-Luc UCL ( Site 1005), Brussels
Reformatus Pulmonologiai Centrum ( Site 1304), Törökbálint
Calvary Mater Newcastle ( Site 3000), Waratah
Campbelltown Hospital ( Site 3002), Campbelltown
Nepean Hospital ( Site 3001), Kingswood
UZ Leuven ( Site 1002), Leuven
Western Health-Sunshine Hospital ( Site 3004), St Albans
Austin Health-Austin Hospital ( Site 3006), Heidelberg
Frankston Hospital-Oncology and Haematology ( Site 3007), Frankston
Gold Coast University Hospital ( Site 3003), Southport
"MHAT Uni Hospital OOD ( Site 2507)", Panagyurishte
CHU UCL Namur Site de Godinne ( Site 1004), Yvoir
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 1306), Kecskemét
Grand Hopital de Charleroi ( Site 1003), Gilly
C.I.U. Hopital Ambroise Pare ( Site 1001), Mons
Groote Schuur Hospital ( Site 5002), Cape Town
AZ Delta ( Site 1000), Roeselare
Petz Aladar Megyei Oktato Korhaz ( Site 1312), Győr
Memorial Sloan Kettering Cancer Center ( Site 0069), New York
National Cancer Center ( Site 3306), Goyang-si
Memorial Sloan Kettering - Westchester-Thoracic Oncology ( Site 0134), Harrison
Institute for Oncology and Radiology of Serbia ( Site 2995), Belgrade
Memorial Sloan Kettering - Nassau ( Site 0131), Uniondale
Memorial Sloan Kettering- Commack ( Site 0132), Commack
Clinique Clairval ( Site 1108), Marseille
SA Pohja-Eesti Regionaalhaigla ( Site 2201), Tallinn
Seoul National University Bundang Hospital ( Site 3301), Seongnam-si
The Catholic University of Korea St. Vincent s Hospital ( Site 3303), Suwon
Penn State Hershey Cancer Institute ( Site 0081), Hershey
Georgetown University ( Site 0017), Washington D.C.
IRCCS Ospedale San Raffaele ( Site 1500), Milan
Istituto Nazionale dei Tumori ( Site 1504), Milan
Istituto Europeo di Oncologia ( Site 1501), Milan
"Communal Noncommercial Enterprise Podillia Regional Oncolog-Chemotherapy Department ( Site 2114)", Vinnytsia
Institut za plucne bolesti Vojvodine Sremska Kamenica ( Site 2991), Kamenitz
Harry & Jeanette Weinberg Cancer Institute ( Site 0045), Baltimore
Azienda Ospedaliera Spedali Civili di Brescia ( Site 1512), Brescia
Hospital Universitario 12 de Octubre ( Site 1902), Madrid
"Municipal non-profit Enterprise Khmelnytskyi Regional Antitumor Center ( Site 2115)", Khmelnytskyi
Hospital Regional Universitario de Malaga ( Site 1905), Málaga
Saint Francis Cancer Center ( Site 0087), Greenville
Hospital Universitario Central de Asturias ( Site 1900), Oviedo
CHU de Bordeaux Hop St ANDRE ( Site 1115), Bordeaux
Moffitt Cancer Center ( Site 0137), Tampa
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 2009), Istanbul
Medipol Universite Hastanesi ( Site 2005), Istanbul
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2003), Istanbul
Ege Universitesi Tip Fakultesi Hastanesi ( Site 2001), Izmir
IRCCS Istituto Oncologico Veneto ( Site 1506), Padua
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento-Oncology Unit ( Site 1513), Verona
The University of Tennessee Medical Center ( Site 0116), Knoxville
CHU Grenoble -Hop Michallon ( Site 1102), Grenoble
University of Kentucky Chandler Medical Center ( Site 0138), Lexington
Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 1907), Seville
A O U Policlinico di Modena ( Site 1503), Modena
Keimyung University Dongsan Hospital CRC room 1 ( Site 3302), Daegu
Fairview Hospital-Moll Cancer Center ( Site 0141), Cleveland
Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 0140), Mayfield Heights
Cleveland Clinic Main ( Site 0139), Cleveland
Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0401), Guadalajara
Institut De Cancerologie De L Ouest ( Site 1110), Saint-Herblain
Fort Wayne Medical Oncology and Hematology ( Site 0034), Fort Wayne
VA Ann Arbor Healthcare System ( Site 0050), Ann Arbor
Inje University Haeundae Paik Hospital ( Site 3307), Busan
Institut de Cancerologie de l Ouest Site Paul Papin ( Site 1103), Angers
Azienda Ospedaliero Universitaria Careggi ( Site 1509), Florence
LSMUL Kauno Klinikos ( Site 2301), Kaunas
SA Tartu Ulikooli Kliinikum ( Site 2200), Tartu
Anti-Cancer Hospital of Thessaloniki Theagenio ( Site 1204), Thessaloniki
St. Vincent Healthcare Frontier Cancer Center ( Site 0056), Billings
University of Chicago Medical Center ( Site 0136), Chicago
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2110), Kharkiv
"Hospital Universitario Dr. Jose Eleuterio Gonzalez ( Site 0404)", Monterrey
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0061), Omaha
Overton Brooks VAMC ( Site 0041), Shreveport
Hopitaux Universitaires Paris Centre-Hopital Cochin ( Site 1105), Paris
Texas Oncology - Dallas (Presbyterian)_McIntyre ( Site 0098), Dallas
Texas Oncology - Dallas (Sammons) ( Site 0093), Dallas
MD Anderson Cancer Center ( Site 0100), Houston
Millennium Research & Clinical Development ( Site 0143), Houston
H.I.A. Sainte-Anne ( Site 1101), Toulon
Ironwood Cancer & Research Centers ( Site 0007), Chandler
Loma Linda University Cancer Center ( Site 0011), Loma Linda
Hopital Avicenne ( Site 1106), Bobigny
Providence Regional Cancer Partnership ( Site 0106), Everett
Multicare Institute For Research And Innovation ( Site 0108), Tacoma
Virginia Mason Memorial- North Star Lodge Cancer Center ( Site 0112), Yakima
Medical Oncology Associates, PS ( Site 0142), Spokane
Peking Union Medical College Hospital ( Site 3102), Beijing
Cancer Hospital Chinese Academy of Medical Sciences ( Site 3104), Beijing
Beijing Cancer hospital-Oncology Radiotherapy Department ( Site 3140), Beijing
Spitalul Municipal Ploiesti ( Site 2801), Ploieşti
Main Military Clinical Hospital n.a. N.N.Burdenko ( Site 1812), Moscow
MROI n.a. P.A. Herzen - branch of FSBI NMICR of MoH of Russia ( Site 1800), Moscow
Beijing Cancer Hospital ( Site 3127), Beijing
The First Hospital of Jilin University ( Site 3132), Changchun
Moscow Regional Oncological Dispensary-Oncology (thoracic surgery) Department №1 ( Site 1815), Balashikha
Shanghai Chest Hospital ( Site 3107), Shanghai
Shanghai Pulmonary Hospital ( Site 3101), Shanghai
Jiangsu Cancer Hospital ( Site 3139), Nanjing
Affiliated Cancer Hospital of Shandong First Medical University ( Site 3100), Jinan
Tianjin Medical University Cancer Institute & Hospital ( Site 3103), Tianjin
Cabinet Medical Oncomed ( Site 2802), Timișoara
Hangzhou Cancer Hospital ( Site 3129), Hanghzou
The 1st Affil Hosp of College of Medicine, Zhejiang Univ ( Site 3131), Hangzhou
Zhejiang Cancer Hospital ( Site 3108), Hangzhou
The Second Affiliated Hospital of Nanchang University ( Site 3106), Nanchang
Fujian Provincial Cancer Hospital ( Site 3126), Fuzhou
The First Affiliated Hospital of Xiamen University ( Site 3121), Xiamen
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2803), Cluj-Napoca
Chongqing Cancer Hospital ( Site 3135), Chongqing
Daping Hospital,Third Military Medical University ( Site 3136), Chongqing
Amethyst Radiotherapy Center-Oncologie Medicala ( Site 2805), Florești
Xiangya Hospital of Central South University ( Site 3137), Changsha
Second Xiangya Hospital of Central-South University ( Site 3128), Changsha
Hunan Cancer Hospital ( Site 3133), Changsha
Republican Clinical Oncology Dispensary-Chemotherapy #1 ( Site 1814), Kazan'
Tongji Medical College Huazhong University of Science and Technology ( Site 3138), Wuhan
Union Hospital, Tongji Medical College of HUST ( Site 3123), Wuhan
Hubei Cancer Hospital ( Site 3120), Wuhan
Henan Cancer Hospital ( Site 3105), Zhengzhou
West China Hospital of Sichuan University ( Site 3114), Chengdu
Peking University Shenzhen Hospital ( Site 3118), Shenzhen
Cancer Hospital Chinese Academy Of Medical Sciences. Shenzhen Center ( Site 3113), Shenzhen
Nizhniy Novgorod Region Oncology Dispensary ( Site 1811), Nizhny Novgorod
Sverdlovsk Regional Oncology Hospital ( Site 1807), Yekaterinburg
Omsk Clinical Oncology Dispensary ( Site 1806), Omsk
Rambam Health Care Campus-Oncology Division ( Site 1401), Haifa
Chaim Sheba Medical Center ( Site 1400), Ramat Gan
Memorial Sloan Kettering - Basking Ridge ( Site 0133), Basking Ridge
John Theurer Cancer Center ( Site 0064), Hackensack
Memorial Sloan Kettering - Monmouth ( Site 0135), Middletown
Memorial Sloan Kettering - Bergen ( Site 0130), Montvale
Rutgers Cancer Institute of New Jersey ( Site 0123), New Brunswick
Cross Cancer Institute ( Site 0206), Edmonton
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0212), Hamilton
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0202), Montreal
McGill University Health Centre ( Site 0210), Montreal
CIUSSS de la Mauricie et du Centre du Quebec ( Site 0200), Trois-Rivières
C.H. de Saint Quentin ( Site 1111), Saint-Quentin
Henry Dunant Hospital ( Site 1205), Athens
Sotiria Regional Chest Diseases Hospital of Athens ( Site 1200), Athens
University General Hospital of Herakleion ( Site 1202), Heraklion
University General Hospital of Larisa ( Site 1201), Larissa
Policlinico Universitario Agostino Gemelli ( Site 1505), Roma
Aichi Cancer Center ( Site 4010), Nagoya
Kobe Minimally Invasive Cancer Center ( Site 4003), Kobe
Takarazuka City Hospital ( Site 4013), Takarazuka
Kanagawa Cancer Center ( Site 4001), Yokohama
Kansai Medical University Hospital ( Site 4009), Hirakata
Osaka Medical and Pharmaceutical University Hospital ( Site 4007), Takatsuki
Shizuoka Cancer Center ( Site 4014), Nakatogari
National Hospital Organization Kyushu Cancer Center ( Site 4000), Fukuoka
Niigata Cancer Center Hospital ( Site 4004), Niigata
Okayama University Hospital ( Site 4012), Okayama
Osaka International Cancer Institute ( Site 4005), Osaka
National Cancer Center Hospital ( Site 4015), Tokyo
Juntendo University Hospital ( Site 4008), Tokyo
Tokyo Metropolitan Komagome Hospital ( Site 4011), Tokyo
Cancer Institute Hospital of JFCR ( Site 4006), Tokyo
Showa Medical University Hospital ( Site 4002), Tokyo
Nacionalinis Vezio Institutas ( Site 2300), Vilnius
Unidade Local de Saude de Santa Maria - Hospital Pulido Valente ( Site 1704), Lisbon
Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE ( Site 1705), Lisbon
Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 1701), Porto
S.C.Focus Lab Plus S.R.L ( Site 2804), Bucharest
Steve Biko Academic Hospital ( Site 5000), Pretoria
Asan Medical Center ( Site 3308), Songpagu
Severance Hospital Yonsei University Health System ( Site 3304), Seoul
Samsung Medical Center ( Site 3300), Seoul
Hospital Duran i Reynals ( Site 1903), L'Hospitalet de Llobregat
Hospital Universitari Vall d Hebron ( Site 1904), Barcelona
Ankara Bilkent Sehir Hastanesi ( Site 2007), Ankara
LISOD. Hospital ( Site 2111), Pliuty
Medical Center of Yuriy Spizhenko LLC.-Clinical Trial ( Site 2104), Kapitanivka Village
Clinic of National Cancer Institute ( Site 2101), Kyiv
Medical Center Verum ( Site 2106), Kyiv
Kyiv City Clinical Oncology Center ( Site 2100), Kyiv
Royal Infirmary Aberdeen ( Site 2403), Aberdeen
Ninewells Hospital and Medical School ( Site 2401), Dundee
Taunton and Somerset Hospital ( Site 2404), Taunton
Barts Health NHS Trust ( Site 2409), London
Guy s & St Thomas NHS Foundation Trust ( Site 2408), London
The Christie NHS Foundation Trust ( Site 2405), Manchester
Merck Sharp & Dohme LLC
INDUSTRY